SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		4 / 8 GLY A 293
HIS A 290
ALA A 353
ILE A 324
 None
 0.77A 1gtnP-2zu0A:
undetectable
1gtnQ-2zu0A:
undetectable		 1gtnP-2zu0A:
10.40
1gtnQ-2zu0A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 11 ASN A  59
ILE A  58
LEU A  41
PHE A 126
HIS A 226
 None
 1.21A 1tw4A-2zu0A:
undetectable		 1tw4A-2zu0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 10 ALA A 239
THR A 240
ALA A 241
GLY A 180
ALA A 208
 None
 0.98A 2f16K-2zu0A:
undetectable
2f16L-2zu0A:
undetectable		 2f16K-2zu0A:
18.56
2f16L-2zu0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 10 ALA A 239
THR A 240
ALA A 241
GLY A 180
ALA A 208
 None
 0.98A 2f16Y-2zu0A:
undetectable
2f16Z-2zu0A:
undetectable		 2f16Y-2zu0A:
18.56
2f16Z-2zu0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		4 / 7 HIS A 170
THR A 199
GLY A 200
TYR A 171
 None
 0.89A 2f6dA-2zu0A:
undetectable		 2f6dA-2zu0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 PHE A 198
SER A  64
HIS A 170
LEU A 129
LEU A  17
 None
 1.08A 2prgB-2zu0A:
undetectable		 2prgB-2zu0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		3 / 3 ASN A 318
LEU A 288
HIS A 290
 None
 0.82A 2q6fB-2zu0A:
undetectable		 2q6fB-2zu0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 9 LEU A  57
SER A  60
THR A 158
ALA A 169
THR A 199
 None
 1.29A 3mdtA-2zu0A:
undetectable		 3mdtA-2zu0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 9 HIS A  15
LEU A  37
LEU A  11
LEU A 133
LEU A 129
 None
 1.37A 3q1eB-2zu0A:
undetectable
3q1eD-2zu0A:
undetectable		 3q1eB-2zu0A:
19.19
3q1eD-2zu0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 9 LEU A 177
ALA A 241
ILE A 270
ILE A 216
LEU A 175
 None
 1.13A 3u7sA-2zu0A:
undetectable		 3u7sA-2zu0A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		4 / 5 LEU A 336
PRO A 276
VAL A 305
ASP A 344
 None
 1.18A 3ufnA-2zu0A:
undetectable
3ufnB-2zu0A:
undetectable		 3ufnA-2zu0A:
14.99
3ufnB-2zu0A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 HIS A 255
HIS A 173
PHE A 189
THR A 158
GLY A  91
 None
 1.42A 4hvcA-2zu0A:
undetectable		 4hvcA-2zu0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		3 / 3 SER A 306
MET A 337
ASP A 344
 None
 0.92A 4mm4B-2zu0A:
undetectable		 4mm4B-2zu0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 ILE A 110
THR A 138
HIS A 173
LEU A  86
LEU A 154
 None
 1.47A 4pbhA-2zu0A:
undetectable		 4pbhA-2zu0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		4 / 6 ALA A 169
ILE A  69
GLY A  67
VAL A  94
 None
 0.82A 4r21A-2zu0A:
undetectable		 4r21A-2zu0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 9 ALA A 169
ILE A  69
GLY A  67
ALA A  66
VAL A  94
 None
 0.89A 4r21B-2zu0A:
undetectable		 4r21B-2zu0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_2
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 10 ARG A 254
ARG A 285
TRP A  49
HIS A 128
LEU A  33
 None
 1.41A 4x3uB-2zu0A:
undetectable		 4x3uB-2zu0A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 THR A 138
ALA A 201
ALA A 134
THR A 130
ASP A 112
 None
 1.38A 5d0xH-2zu0A:
undetectable
5d0xI-2zu0A:
undetectable		 5d0xH-2zu0A:
20.14
5d0xI-2zu0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 LEU A 418
ILE A 367
THR A 398
ALA A 394
LEU A 335
 None
 1.24A 5ienA-2zu0A:
undetectable		 5ienA-2zu0A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 THR A 138
ALA A 201
ALA A 134
THR A 130
ASP A 112
 None
 1.35A 5l5zH-2zu0A:
undetectable
5l5zI-2zu0A:
undetectable		 5l5zH-2zu0A:
20.14
5l5zI-2zu0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 12 THR A 138
ALA A 201
ALA A 134
THR A 130
ASP A 112
 None
 1.36A 5l5zV-2zu0A:
undetectable
5l5zW-2zu0A:
undetectable		 5l5zV-2zu0A:
20.14
5l5zW-2zu0A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 11 ALA A 239
THR A 240
ALA A 241
GLY A 180
ALA A 208
 None
 0.97A 5lf3K-2zu0A:
undetectable
5lf3L-2zu0A:
undetectable		 5lf3K-2zu0A:
16.83
5lf3L-2zu0A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 11 ALA A 239
THR A 240
ALA A 241
GLY A 180
ALA A 208
 None
 0.96A 5lf3Y-2zu0A:
undetectable
5lf3Z-2zu0A:
undetectable		 5lf3Y-2zu0A:
16.83
5lf3Z-2zu0A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		4 / 7 ARG A 413
PHE A 246
LEU A 401
SER A 243
 None
 1.30A 5uxcA-2zu0A:
undetectable		 5uxcA-2zu0A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		4 / 8 GLU A 187
HIS A 227
PHE A 126
LEU A  41
 None
 0.97A 5y2tB-2zu0A:
undetectable		 5y2tB-2zu0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		3 / 3 ARG A 172
LYS A 217
ARG A 114
 None
 1.47A 6az3C-2zu0A:
undetectable
6az3L-2zu0A:
undetectable
6az3M-2zu0A:
undetectable		 6az3C-2zu0A:
11.78
6az3L-2zu0A:
11.11
6az3M-2zu0A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		5 / 10 VAL A 277
SER A 306
GLY A 249
GLY A 415
ARG A 413
 None
 1.17A 6eu9B-2zu0A:
undetectable		 6eu9B-2zu0A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2zu0 PROTEIN SUFD
(Escherichia
coli) 		3 / 3 LYS A 150
VAL A  84
ASP A  82
 None
 0.54A 6fgdA-2zu0A:
undetectable		 6fgdA-2zu0A:
23.77