SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 PRO A 263
VAL A 366
TYR A 277
GLU A 280
 None
 1.44A 1m9jB-2zu8A:
0.6		 1m9jB-2zu8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 100
ILE A 101
PHE A 104
ILE A  74
 None
 0.85A 1oniB-2zu8A:
undetectable
1oniC-2zu8A:
undetectable		 1oniB-2zu8A:
17.54
1oniC-2zu8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 8 LEU A 262
TYR A 277
ILE A 299
ARG A 281
ILE A 261
 None
 1.23A 2bu8A-2zu8A:
undetectable		 2bu8A-2zu8A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  66
ILE A 112
LEU A 394
VAL A 181
VAL A 177
 None
 1.14A 2ygnA-2zu8A:
undetectable		 2ygnA-2zu8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ILE A 370
LEU A 154
MET A 256
THR A 255
 None
 1.06A 3ag4N-2zu8A:
undetectable
3ag4W-2zu8A:
undetectable		 3ag4N-2zu8A:
20.08
3ag4W-2zu8A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 LYS A 257
LYS A 371
ILE A 261
ARG A 281
THR A 255
 None
 1.29A 3ijdB-2zu8A:
0.6		 3ijdB-2zu8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ASN A 171
GLU A 251
GLY A 165
MET A   1
VAL A 177
 None
 1.03A 3nk7A-2zu8A:
2.1		 3nk7A-2zu8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 370
LEU A 154
MET A 256
THR A 255
 None
 1.11A 3wg7A-2zu8A:
undetectable
3wg7J-2zu8A:
undetectable		 3wg7A-2zu8A:
20.08
3wg7J-2zu8A:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 116
GLU A  97
ASN A  61
 None
 0.86A 4bupB-2zu8A:
undetectable		 4bupB-2zu8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.33A 4foxF-2zu8A:
undetectable		 4foxF-2zu8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 MET A 256
LEU A 262
ILE A  56
GLY A 152
LEU A 154
 None
 1.21A 4pxmB-2zu8A:
undetectable		 4pxmB-2zu8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A 186
LEU A   3
LEU A   2
ILE A  46
 None
 0.84A 4ubsA-2zu8A:
undetectable		 4ubsA-2zu8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A 130
LEU A 150
PHE A 264
ILE A 370
 None
 0.84A 4xv2A-2zu8A:
undetectable		 4xv2A-2zu8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.33A 5fctA-2zu8A:
undetectable		 5fctA-2zu8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  82
ILE A 112
PHE A 104
VAL A  57
ILE A  74
 None
 1.13A 5lg3F-2zu8A:
undetectable		 5lg3F-2zu8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  82
ILE A 112
PHE A 104
VAL A  57
ILE A  74
 None
 1.07A 5lg3G-2zu8A:
undetectable		 5lg3G-2zu8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 201
GLU A 305
TRP A 202
 None
 0.89A 5odiD-2zu8A:
1.9		 5odiD-2zu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 201
GLU A 305
TRP A 202
 None
 1.05A 5odqD-2zu8A:
1.9		 5odqD-2zu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 201
GLU A 305
TRP A 202
 None
 0.91A 5odrD-2zu8A:
1.9		 5odrD-2zu8A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 HIS A 312
HIS A 310
TYR A 180
GLU A 251
 GDD  A 395 (-3.6A)
GDD  A 395 ( 4.6A)
None
None
 1.29A 5pahA-2zu8A:
undetectable		 5pahA-2zu8A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 116
GLU A  97
ASN A  61
 None
 0.96A 5wbvA-2zu8A:
undetectable		 5wbvA-2zu8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 116
GLU A  97
ASN A  61
 None
 0.96A 5wbvB-2zu8A:
undetectable		 5wbvB-2zu8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 169
VAL A  55
ILE A 112
ALA A  73
LEU A  71
 GDD  A 395 (-3.6A)
None
None
None
None
 1.25A 6h1lA-2zu8A:
undetectable		 6h1lA-2zu8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A 169
VAL A  55
ILE A 112
ALA A  73
LEU A  71
 GDD  A 395 (-3.6A)
None
None
None
None
 1.26A 6h1lB-2zu8A:
undetectable		 6h1lB-2zu8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.28A 6r2eA-2zu8A:
undetectable		 6r2eA-2zu8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.33A 6r2eB-2zu8A:
undetectable		 6r2eB-2zu8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.33A 6r2eC-2zu8A:
undetectable		 6r2eC-2zu8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.30A 6r2eD-2zu8A:
undetectable		 6r2eD-2zu8A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 381
TRP A 378
LEU A 155
ASP A 119
GLY A 121
 None
 1.32A 6r2eG-2zu8A:
undetectable		 6r2eG-2zu8A:
20.69