SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		3 / 3 TRP A  78
ALA A  75
VAL A   9
 None
 0.80A 1c4dA-2zuaA:
undetectable
1c4dB-2zuaA:
undetectable		 1c4dA-2zuaA:
10.08
1c4dB-2zuaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		3 / 3 ALA A  75
VAL A   9
TRP A  78
 None
 0.93A 1c4dC-2zuaA:
undetectable
1c4dD-2zuaA:
undetectable		 1c4dC-2zuaA:
10.08
1c4dD-2zuaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		5 / 12 PRO A  13
GLY A 109
ASN A 115
SER A  70
GLY A 113
 None
 1.25A 1ffyA-2zuaA:
undetectable		 1ffyA-2zuaA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 8 HIS A 118
GLU A 131
HIS A  51
ALA A 127
 None
 0.79A 2bnnA-2zuaA:
undetectable
2bnnB-2zuaA:
undetectable		 2bnnA-2zuaA:
20.19
2bnnB-2zuaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 8 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.79A 3fi0B-2zuaA:
undetectable		 3fi0B-2zuaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 7 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.74A 3fi0E-2zuaA:
undetectable		 3fi0E-2zuaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 8 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.74A 3fi0G-2zuaA:
undetectable		 3fi0G-2zuaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 8 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.77A 3fi0I-2zuaA:
undetectable		 3fi0I-2zuaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 8 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.73A 3fi0Q-2zuaA:
undetectable		 3fi0Q-2zuaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 5 GLU A  79
LEU A  33
GLN A 146
GLY A  32
 None
 1.12A 3pp1A-2zuaA:
undetectable		 3pp1A-2zuaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		3 / 3 TYR A 108
ASP A  30
ASP A  23
 None
 0.79A 3r24A-2zuaA:
undetectable		 3r24A-2zuaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		5 / 11 PHE A   8
ASN A 128
GLY A 119
GLY A  37
MET A  41
 None
 1.36A 4a6nB-2zuaA:
undetectable		 4a6nB-2zuaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		5 / 11 PHE A   8
ASN A 128
GLY A 119
GLY A  37
MET A  41
 None
 1.36A 4a6nC-2zuaA:
undetectable		 4a6nC-2zuaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 7 ARG A 105
ILE A 117
ASN A 115
GLU A  54
 None
 1.10A 4a97E-2zuaA:
undetectable		 4a97E-2zuaA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2zua NUCLEOSIDE
DIPHOSPHATE KINASE
(Haloarcula
quadrata) 		4 / 7 HIS A 118
ASP A  95
THR A  94
HIS A  51
 None
 1.48A 6nmpN-2zuaA:
undetectable
6nmpP-2zuaA:
undetectable		 6nmpN-2zuaA:
15.42
6nmpP-2zuaA:
22.31