SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zuc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		5 / 12 ALA A 297
GLN A 126
THR A 110
ILE A 252
LEU A 127
 None
 1.19A 1dhfB-2zucA:
undetectable		 1dhfB-2zucA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		3 / 3 LYS A  12
GLY A 282
PRO A 281
 None
 1.00A 2hreB-2zucA:
undetectable		 2hreB-2zucA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		4 / 8 GLN A 122
PHE A 116
GLY A 117
GLY A 151
 None
 0.96A 2y6rB-2zucA:
undetectable		 2y6rB-2zucA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		5 / 11 LYS A  27
LEU A  28
GLY A  52
THR A  57
ILE A  61
 None
 1.37A 3bexE-2zucA:
undetectable
3bexF-2zucA:
undetectable		 3bexE-2zucA:
21.65
3bexF-2zucA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		4 / 6 THR A 213
PHE A 216
GLN A 187
LEU A 237
 None
 1.16A 3bgdA-2zucA:
undetectable		 3bgdA-2zucA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		4 / 6 GLY A  92
THR A  91
LEU A  96
ASP A 321
 None
 1.00A 3ps9A-2zucA:
2.6		 3ps9A-2zucA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		3 / 3 PRO A 281
LEU A 237
GLN A 230
 None
 0.62A 4pevB-2zucA:
3.6		 4pevB-2zucA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		5 / 12 ILE A 319
THR A 108
THR A 110
LEU A 127
LEU A 305
 None
 1.12A 4qynA-2zucA:
undetectable		 4qynA-2zucA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		3 / 3 THR A 213
ASN A 255
SER A 211
 None
 0.73A 4tvtA-2zucA:
undetectable		 4tvtA-2zucA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		4 / 7 THR A 152
THR A 149
THR A 254
THR A 121
 None
 0.92A 4z90A-2zucA:
undetectable
4z90B-2zucA:
undetectable
4z90C-2zucA:
undetectable
4z90D-2zucA:
undetectable
4z90E-2zucA:
undetectable		 4z90A-2zucA:
23.46
4z90B-2zucA:
23.46
4z90C-2zucA:
23.46
4z90D-2zucA:
23.46
4z90E-2zucA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		4 / 7 THR A 152
THR A 149
THR A 254
THR A 121
 None
 0.91A 4z91F-2zucA:
1.7
4z91G-2zucA:
undetectable
4z91H-2zucA:
1.6
4z91I-2zucA:
1.6
4z91J-2zucA:
undetectable		 4z91F-2zucA:
23.46
4z91G-2zucA:
23.46
4z91H-2zucA:
23.46
4z91I-2zucA:
23.46
4z91J-2zucA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA
(Sulfolobus
solfataricus) 		4 / 7 THR A 254
THR A 121
THR A 152
THR A 149
 None
 0.91A 4z91F-2zucA:
1.7
4z91G-2zucA:
undetectable
4z91H-2zucA:
1.6
4z91I-2zucA:
1.6
4z91J-2zucA:
undetectable		 4z91F-2zucA:
23.46
4z91G-2zucA:
23.46
4z91H-2zucA:
23.46
4z91I-2zucA:
23.46
4z91J-2zucA:
23.46