SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 135
GLY A 137
ASN A 141
GLY A 384
VAL A 418
 None
 0.75A 1ffyA-2zufA:
13.7		 1ffyA-2zufA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A 576
GLU A 578
LEU A 579
VAL A 613
 None
G  B 922 ( 4.9A)
None
None
 0.82A 1hk2A-2zufA:
3.8		 1hk2A-2zufA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A 135
GLY A 137
HIS A 138
GLY A 384
VAL A 418
 None
 0.58A 1pg2A-2zufA:
18.3		 1pg2A-2zufA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 135
GLY A 137
HIS A 138
GLY A 384
VAL A 418
 None
 0.82A 1qu2A-2zufA:
13.6		 1qu2A-2zufA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 HIS A 135
GLY A 137
HIS A 138
ASN A 141
VAL A 418
 None
 0.71A 1qu3A-2zufA:
15.9		 1qu3A-2zufA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 VAL A 613
LEU A 553
ARG A 558
PHE A 556
 None
 1.09A 1s8fB-2zufA:
undetectable		 1s8fB-2zufA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 207
GLU A 248
LYS A 183
LEU A 180
 None
 1.07A 1sn0B-2zufA:
undetectable
1sn0D-2zufA:
undetectable		 1sn0B-2zufA:
11.82
1sn0D-2zufA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 ILE A 394
ALA A 397
GLN A 399
LEU A 410
ALA A 407
LEU A 322
 None
 1.27A 1xiuA-2zufA:
undetectable		 1xiuA-2zufA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ALA A 397
LEU A 398
PHE A 403
PHE A 292
LEU A 340
 None
 0.89A 1y7iB-2zufA:
undetectable		 1y7iB-2zufA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 620
GLY A 564
ALA A 563
ASP A 566
ILE A 572
 None
None
None
A  B 917 ( 4.9A)
None
 0.99A 2f81A-2zufA:
undetectable		 2f81A-2zufA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 620
GLY A 564
ALA A 563
ASP A 566
ILE A 572
 None
None
None
A  B 917 ( 4.9A)
None
 0.94A 2hs2A-2zufA:
undetectable		 2hs2A-2zufA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A 272
ARG A 276
ARG A 275
 None
 1.04A 2j9dA-2zufA:
undetectable
2j9dC-2zufA:
undetectable		 2j9dA-2zufA:
11.43
2j9dC-2zufA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 LEU A 620
GLY A 564
ALA A 563
ASP A 566
ALA A 617
ILE A 572
 None
None
None
A  B 917 ( 4.9A)
None
None
 1.13A 2nmzA-2zufA:
undetectable		 2nmzA-2zufA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 620
GLY A 564
ALA A 563
ASP A 566
ILE A 572
 None
None
None
A  B 917 ( 4.9A)
None
 0.92A 3cyxA-2zufA:
undetectable		 3cyxA-2zufA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 224
LEU A 218
ARG A 216
 None
 0.73A 3hcnB-2zufA:
undetectable		 3hcnB-2zufA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 SER A 543
PHE A 586
LEU A 593
LEU A 604
ILE A 517
 None
None
C  B 935 ( 3.7A)
None
C  B 935 ( 4.2A)
 1.19A 3ko0A-2zufA:
undetectable
3ko0B-2zufA:
undetectable
3ko0I-2zufA:
undetectable
3ko0J-2zufA:
undetectable		 3ko0A-2zufA:
8.35
3ko0B-2zufA:
8.35
3ko0I-2zufA:
8.35
3ko0J-2zufA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 593
LEU A 604
ILE A 517
SER A 543
PHE A 586
 C  B 935 ( 3.7A)
None
C  B 935 ( 4.2A)
None
None
 1.08A 3ko0K-2zufA:
undetectable
3ko0L-2zufA:
undetectable
3ko0M-2zufA:
undetectable
3ko0N-2zufA:
undetectable		 3ko0K-2zufA:
8.35
3ko0L-2zufA:
8.35
3ko0M-2zufA:
8.35
3ko0N-2zufA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 292
LEU A 340
ALA A 393
LEU A 322
 None
 1.00A 3t3zA-2zufA:
undetectable		 3t3zA-2zufA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 292
LEU A 340
ALA A 393
LEU A 322
 None
 1.00A 3t3zB-2zufA:
undetectable		 3t3zB-2zufA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 PHE A 292
LEU A 340
ALA A 393
LEU A 322
 None
 0.92A 3t3zD-2zufA:
undetectable		 3t3zD-2zufA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 286
ASN A 291
MET A 306
ALA A 397
ILE A 336
 None
 1.14A 3ut5D-2zufA:
undetectable		 3ut5D-2zufA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 LEU A 240
TYR A 241
LEU A 235
TYR A 176
 None
 1.07A 4f3tA-2zufA:
3.5		 4f3tA-2zufA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLU A 124
GLN A 162
TRP A 269
ILE A 165
 None
 1.28A 4ii8A-2zufA:
undetectable		 4ii8A-2zufA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 380
ALA A 149
ALA A 563
LYS A 565
ILE A 378
 None
 1.04A 4kjjA-2zufA:
undetectable		 4kjjA-2zufA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 LEU A 193
ILE A 203
VAL A 255
THR A 256
 None
 0.57A 4ma7A-2zufA:
undetectable		 4ma7A-2zufA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 11 ILE A 394
ALA A 397
GLN A 399
LEU A 410
ALA A 407
LEU A 322
 None
 1.27A 4nqaA-2zufA:
undetectable		 4nqaA-2zufA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 207
GLY A 208
VAL A 128
HIS A 135
THR A 436
 None
 1.14A 4okwA-2zufA:
undetectable		 4okwA-2zufA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ASN A 201
GLU A 187
LEU A 245
PHE A 186
 None
 1.02A 4twdI-2zufA:
2.8
4twdJ-2zufA:
undetectable		 4twdI-2zufA:
19.55
4twdJ-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 240
TYR A 241
LEU A 235
TYR A 176
 None
 1.11A 5ki6A-2zufA:
3.7		 5ki6A-2zufA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 540
PRO A  93
ASP A  91
 None
 0.43A 5l8dB-2zufA:
2.0		 5l8dB-2zufA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  76
ILE A  90
PHE A  95
VAL A   9
GLU A  32
 None
 1.28A 5lg3F-2zufA:
1.7		 5lg3F-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  76
ILE A  90
PHE A  95
VAL A   9
GLU A  32
 None
 1.26A 5lg3G-2zufA:
undetectable		 5lg3G-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ILE A  76
ILE A  90
PHE A  95
VAL A   9
GLU A  32
 None
 1.23A 5lg3H-2zufA:
3.6		 5lg3H-2zufA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 THR A 540
PRO A  93
ASP A  91
 None
 0.43A 5mwuB-2zufA:
2.0		 5mwuB-2zufA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 474
TYR A 619
ARG A 447
ALA A 444
ALA A 475
 None
 1.21A 5n5dA-2zufA:
undetectable		 5n5dA-2zufA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 240
TYR A 241
LEU A 235
TYR A 176
 None
 1.08A 5t7bA-2zufA:
3.6		 5t7bA-2zufA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  40
ARG A 547
ASP A  35
 None
 0.85A 5zvgA-2zufA:
undetectable		 5zvgA-2zufA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ASP A  40
ARG A 547
ASP A  35
 None
 0.87A 5zvgB-2zufA:
undetectable		 5zvgB-2zufA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2zuf ARGINYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 GLY A 156
LEU A 155
VAL A 159
ALA A 149
LEU A 620
 None
 1.06A 6czmA-2zufA:
undetectable
6czmC-2zufA:
undetectable		 6czmA-2zufA:
21.50
6czmC-2zufA:
21.50