SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 8 GLY A 272
GLY A  55
LEU A  34
ASP A  44
None
0.83A 1aegA-2zukA:
undetectable
1aegA-2zukA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ALA A  89
GLU A  90
LEU A  88
LEU A 275
LEU A 269
None
1.20A 1errB-2zukA:
undetectable
1errB-2zukA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ILE A 199
ALA A 201
ALA A 202
VAL A 194
LEU A 187
None
0.98A 1fm6A-2zukA:
undetectable
1fm6A-2zukA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 6 ALA A 411
SER A  53
ARG A 330
LEU A 412
None
1.18A 1gahA-2zukA:
undetectable
1gahA-2zukA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A  50
ALA A  51
SER A  53
GLY A  55
LEU A  54
None
1.10A 1igxA-2zukA:
undetectable
1igxA-2zukA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ALA A 280
ILE A 284
VAL A 236
PHE A 203
ILE A 233
None
1.00A 1xozA-2zukA:
undetectable
1xozA-2zukA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 LEU A 395
GLY A 392
ASP A 210
GLY A 435
VAL A 385
None
0.92A 2f8gB-2zukA:
undetectable
2f8gB-2zukA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ALA A 280
ILE A 284
VAL A 236
ALA A 202
ILE A 233
None
1.07A 2h42B-2zukA:
undetectable
2h42B-2zukA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 6 LEU A 329
GLY A 350
LEU A 333
SER A 334
None
0.82A 3aiaA-2zukA:
undetectable
3aiaA-2zukA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 HIS A  58
VAL A 309
ILE A 313
LEU A 401
THR A 402
None
1.04A 3fw3B-2zukA:
undetectable
3fw3B-2zukA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A 211
GLY A 389
ASN A 391
ALA A 134
LEU A 213
None
1.06A 3mteA-2zukA:
undetectable
3mteA-2zukA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A 211
GLY A 389
ASN A 391
ALA A 134
LEU A 213
None
1.03A 3p2kC-2zukA:
undetectable
3p2kC-2zukA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 5 LEU A 310
LEU A 269
GLY A 268
GLY A 270
None
0.71A 3si7C-2zukA:
undetectable
3si7D-2zukA:
undetectable
3si7C-2zukA:
20.14
3si7D-2zukA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 LEU A 250
ILE A 313
LEU A 269
GLY A 268
ALA A 305
None
0.87A 3uwlB-2zukA:
undetectable
3uwlB-2zukA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ILE A 403
GLY A  50
ALA A  51
GLY A  55
LEU A  54
None
1.03A 4e1gB-2zukA:
undetectable
4e1gB-2zukA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 SER A  95
LEU A 250
ALA A 277
GLY A 268
LEU A 269
None
1.24A 4j7xB-2zukA:
2.6
4j7xB-2zukA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 6 SER A 247
GLY A 219
ASP A 218
GLY A 257
None
0.94A 4koeA-2zukA:
2.3
4koeB-2zukA:
2.3
4koeC-2zukA:
undetectable
4koeA-2zukA:
23.09
4koeB-2zukA:
23.09
4koeC-2zukA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 10 ASP A 238
VAL A 240
VAL A 264
SER A 109
SER A 276
PLP  A 450 (-2.9A)
PLP  A 450 (-4.3A)
None
PLP  A 450 (-3.8A)
None
1.45A 4ldoA-2zukA:
undetectable
4ldoA-2zukA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 PRO A 206
GLU A 205
CYH A 237
ASN A 114
GLY A 110
None
PLP  A 450 (-4.0A)
None
PLP  A 450 (-4.6A)
PLP  A 450 (-3.4A)
1.31A 4oadA-2zukA:
undetectable
4oadA-2zukA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 8 ARG A 324
ALA A 322
GLY A 326
LEU A 351
LEU A 401
None
1.32A 4po0A-2zukA:
undetectable
4po0A-2zukA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 6 GLY A 219
ASP A 218
GLY A 257
SER A 247
None
0.93A 4z53A-2zukA:
undetectable
4z53B-2zukA:
2.1
4z53A-2zukA:
20.70
4z53B-2zukA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A 270
GLY A 272
GLY A  55
LEU A  54
LEU A 269
None
1.01A 5c0oE-2zukA:
2.3
5c0oE-2zukA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A 270
GLY A 272
GLY A  55
LEU A  54
LEU A 269
None
0.97A 5c0oG-2zukA:
2.3
5c0oG-2zukA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 PRO A 400
GLY A 268
GLY A  55
LEU A  54
LEU A 244
None
0.99A 5c0oG-2zukA:
2.3
5c0oG-2zukA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 9 ALA A 277
GLY A 266
LEU A 269
LEU A  92
GLU A 239
None
1.21A 5dqfA-2zukA:
undetectable
5dqfA-2zukA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 9 ALA A 411
LEU A  42
GLY A 382
LEU A 383
LEU A  45
None
1.22A 5dqfA-2zukA:
undetectable
5dqfA-2zukA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 5 SER A  95
ALA A  94
HIS A 251
LEU A  92
None
1.14A 5dzkb-2zukA:
undetectable
5dzkp-2zukA:
undetectable
5dzkb-2zukA:
20.45
5dzkp-2zukA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 6 SER A  95
ALA A  94
HIS A 251
LEU A  92
None
1.12A 5dzkB-2zukA:
undetectable
5dzkP-2zukA:
undetectable
5dzkB-2zukA:
20.45
5dzkP-2zukA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 5 SER A  95
ALA A  94
HIS A 251
LEU A  92
None
1.12A 5dzkc-2zukA:
undetectable
5dzkq-2zukA:
undetectable
5dzkc-2zukA:
20.45
5dzkq-2zukA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 5 SER A  95
ALA A  94
HIS A 251
LEU A 310
None
1.36A 5dzkf-2zukA:
undetectable
5dzkt-2zukA:
undetectable
5dzkf-2zukA:
20.45
5dzkt-2zukA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A 271
GLY A  50
GLY A 268
THR A 398
ILE A 403
None
0.95A 5ehgC-2zukA:
undetectable
5ehgC-2zukA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ALA A 116
PHE A 147
GLY A 143
GLY A 200
VAL A 130
None
0.96A 5i73A-2zukA:
undetectable
5i73A-2zukA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 6 VAL A 388
LEU A  45
SER A  46
ILE A 403
None
0.97A 5jw1A-2zukA:
undetectable
5jw1A-2zukA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 GLY A 271
GLY A  50
GLY A 268
THR A 398
ILE A 403
None
0.95A 5kqrA-2zukA:
undetectable
5kqrA-2zukA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 8 LEU A 191
ILE A 131
ALA A 202
PHE A 224
None
0.79A 5m0oC-2zukA:
undetectable
5m0oC-2zukA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 8 HIS A  58
VAL A 309
LEU A 401
THR A 402
None
0.87A 5tt3H-2zukA:
undetectable
5tt3H-2zukA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
4 / 8 LEU A  88
LEU A 310
LEU A 273
GLY A 272
None
0.90A 6ce2A-2zukA:
undetectable
6ce2A-2zukA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
3 / 3 ARG A 222
PHE A 258
GLY A 257
None
0.81A 6fgdA-2zukA:
undetectable
6fgdA-2zukA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae)
5 / 12 ASP A 238
VAL A 240
VAL A 264
SER A 109
SER A 276
PLP  A 450 (-2.9A)
PLP  A 450 (-4.3A)
None
PLP  A 450 (-3.8A)
None
1.44A 6h7mB-2zukA:
undetectable
6h7mB-2zukA:
11.50