SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 8 ALA A 196
LEU A 190
ALA A 573
THR A 276
None
0.92A 1ie4B-2zuyA:
undetectable
1ie4D-2zuyA:
3.1
1ie4B-2zuyA:
12.10
1ie4D-2zuyA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 10 GLY A 373
HIS A 584
VAL A 567
ALA A 402
ILE A 346
None
1.07A 1likA-2zuyA:
undetectable
1likA-2zuyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 9 GLY A 240
GLU A   9
GLY A 124
GLY A 194
ASP A 193
None
None
None
None
CA  A 624 (-3.0A)
1.19A 1mxdA-2zuyA:
undetectable
1mxdA-2zuyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 GLN A   7
ILE A 603
TYR A 602
None
0.61A 1vifA-2zuyA:
undetectable
1vifA-2zuyA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 GLY A 173
GLU A 154
ASN A 175
None
0.66A 1zq9A-2zuyA:
undetectable
1zq9A-2zuyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 7 ALA A 578
ARG A 271
ASP A 368
TYR A 579
None
None
CA  A 621 (-2.6A)
None
1.16A 2e5dA-2zuyA:
undetectable
2e5dB-2zuyA:
undetectable
2e5dA-2zuyA:
23.52
2e5dB-2zuyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 11 ASN A 576
ALA A 196
ILE A 126
PHE A 185
ILE A 170
None
1.03A 2h42A-2zuyA:
undetectable
2h42A-2zuyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 HIS A 371
PHE A 385
ARG A 419
GLY A 436
None
1.34A 2i30A-2zuyA:
undetectable
2i30A-2zuyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 8 ILE A 603
ASP A  34
LEU A  31
GLY A  32
None
0.96A 2tsrB-2zuyA:
undetectable
2tsrB-2zuyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 8 GLY A 403
GLU A 383
ILE A 346
ALA A 351
None
CA  A 625 (-2.3A)
None
None
0.95A 3aodA-2zuyA:
undetectable
3aodA-2zuyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 8 HIS A 388
GLY A 367
ASN A 329
PHE A 385
None
1.42A 3ccfA-2zuyA:
undetectable
3ccfA-2zuyA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 THR A 236
ILE A 170
LEU A 172
THR A 202
None
0.76A 3deuB-2zuyA:
undetectable
3deuB-2zuyA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 5 ARG A 283
ASP A 189
ASP A 191
ASP A 193
None
CA  A 624 (-3.2A)
CA  A 624 (-2.9A)
CA  A 624 (-3.0A)
1.47A 3naiC-2zuyA:
undetectable
3naiC-2zuyA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 LYS A 393
SER A 361
GLN A 327
None
1.20A 3si7A-2zuyA:
undetectable
3si7A-2zuyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 THR A 242
GLY A 240
ILE A 198
LEU A 246
None
1.04A 4acbC-2zuyA:
undetectable
4acbC-2zuyA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 7 ASP A 125
ASP A 191
GLU A 241
ASP A 189
CA  A 623 (-3.2A)
CA  A 624 (-2.9A)
None
CA  A 624 (-3.2A)
1.13A 4fevB-2zuyA:
undetectable
4fevB-2zuyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 7 ASP A 125
ASP A 191
GLU A 241
ASP A 189
CA  A 623 (-3.2A)
CA  A 624 (-2.9A)
None
CA  A 624 (-3.2A)
1.13A 4fewB-2zuyA:
undetectable
4fewB-2zuyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 8 ASP A 125
ASP A 191
GLU A 241
ASP A 189
CA  A 623 (-3.2A)
CA  A 624 (-2.9A)
None
CA  A 624 (-3.2A)
1.16A 4gkhD-2zuyA:
undetectable
4gkhD-2zuyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 PRO A 103
ILE A 135
TYR A 160
LEU A 167
GLY A 240
None
1.02A 4l9qB-2zuyA:
undetectable
4l9qB-2zuyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 5 PRO A 439
GLY A 441
ASP A 459
ASP A 443
None
1.02A 4n48B-2zuyA:
undetectable
4n48B-2zuyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 TYR A 251
ARG A 290
ALA A 289
MET A 288
None
1.04A 4o79B-2zuyA:
undetectable
4o79B-2zuyA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 TYR A 251
ARG A 290
ALA A 289
MET A 288
None
1.08A 4o7gB-2zuyA:
undetectable
4o7gB-2zuyA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 8 THR A  12
SER A  85
ASP A 129
TYR A 132
None
None
CA  A 623 (-2.9A)
None
1.15A 4qb9D-2zuyA:
undetectable
4qb9D-2zuyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 GLY A 240
GLU A 241
PHE A 166
LEU A 546
ALA A 121
None
1.27A 4wcxC-2zuyA:
undetectable
4wcxC-2zuyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 GLY A 153
TYR A 151
ILE A 176
LEU A 172
GLY A 179
None
1.12A 5d4uA-2zuyA:
undetectable
5d4uA-2zuyA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 GLY A 153
TYR A 151
ILE A 176
LEU A 172
GLY A 179
None
1.10A 5d4uB-2zuyA:
undetectable
5d4uB-2zuyA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 TYR A 293
TYR A 347
GLY A 367
GLU A 389
None
None
None
CA  A 621 (-2.5A)
1.26A 5emlA-2zuyA:
undetectable
5emlA-2zuyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 GLY A 365
GLN A 386
LYS A 393
None
0.86A 5imsB-2zuyA:
undetectable
5imsB-2zuyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 7 GLY A 403
GLY A 381
LEU A 375
GLU A 344
None
CA  A 625 (-4.3A)
None
CA  A 628 ( 2.1A)
0.79A 5izfA-2zuyA:
undetectable
5izfA-2zuyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 THR A 362
SER A 361
TYR A 360
None
0.81A 5jsdA-2zuyA:
undetectable
5jsdA-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 THR A 362
SER A 361
TYR A 360
None
0.83A 5jsdB-2zuyA:
undetectable
5jsdB-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 THR A 362
SER A 361
TYR A 360
None
0.81A 5jsdC-2zuyA:
undetectable
5jsdC-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 THR A 362
SER A 361
TYR A 360
None
0.82A 5jseA-2zuyA:
undetectable
5jseA-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 THR A 362
SER A 361
TYR A 360
None
0.82A 5jseB-2zuyA:
undetectable
5jseB-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 THR A 362
SER A 361
TYR A 360
None
0.82A 5jseC-2zuyA:
undetectable
5jseC-2zuyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 TYR A 292
ASP A 390
HIS A 388
TYR A 579
None
1.31A 5ov9A-2zuyA:
undetectable
5ov9A-2zuyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 GLY A 124
GLU A   9
LEU A 162
GLY A  14
GLY A 128
None
1.28A 5tuiB-2zuyA:
undetectable
5tuiB-2zuyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 ARG A 169
PHE A 185
PHE A 238
THR A 202
None
1.13A 5vceA-2zuyA:
undetectable
5vceA-2zuyA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 6 ILE A 603
ASP A  34
LEU A  31
GLY A  32
None
0.90A 5x5qE-2zuyA:
undetectable
5x5qE-2zuyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 LEU A 524
PHE A 467
ILE A 572
ILE A 346
LEU A 332
None
1.21A 5y2tB-2zuyA:
undetectable
5y2tB-2zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 10 ALA A 335
GLY A 373
ASP A 374
SER A 378
ASP A 401
None
None
CA  A 625 (-3.0A)
None
None
1.47A 6clxB-2zuyA:
undetectable
6clxB-2zuyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
2zuy YESX PROTEIN
(Bacillus
subtilis)
4 / 5 GLY A 266
ASN A 146
ARG A 290
ARG A 271
None
1.39A 6dwdB-2zuyA:
undetectable
6dwdD-2zuyA:
undetectable
6dwdB-2zuyA:
21.42
6dwdD-2zuyA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
5 / 12 LEU A 172
GLY A 205
ILE A 213
ILE A 157
ASP A 208
None
0.99A 6emuA-2zuyA:
undetectable
6emuA-2zuyA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)
2zuy YESX PROTEIN
(Bacillus
subtilis)
3 / 3 TRP A 168
ILE A 135
GLU A 197
None
None
CA  A 624 (-2.2A)
0.85A 6hcxA-2zuyA:
2.8
6hcxA-2zuyA:
9.49