SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zvb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 GLU A  65
LEU A  97
ILE A  32
ARG A  70
GLU A  69
 None
 1.50A 1l7hA-2zvbA:
undetectable		 1l7hA-2zvbA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 SER A  81
LEU A  61
LEU A 158
LEU A 157
 None
 0.99A 2bfpA-2zvbA:
undetectable		 2bfpA-2zvbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 SER A  81
LEU A  61
LEU A 158
LEU A 157
 None
 0.96A 2bfpB-2zvbA:
undetectable		 2bfpB-2zvbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 7 VAL A 178
ALA A 171
PRO A 144
THR A 257
 None
 1.00A 2q6oA-2zvbA:
undetectable		 2q6oA-2zvbA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 SER A 153
ILE A 164
ASP A 156
ARG A 187
 None
 1.10A 2v57A-2zvbA:
undetectable		 2v57A-2zvbA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 SER A 153
ILE A 164
ASP A 156
ARG A 187
 None
 1.11A 2v57C-2zvbA:
undetectable		 2v57C-2zvbA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		6 / 12 TYR A  37
ALA A  21
VAL A   7
GLY A  10
GLY A  16
GLY A 130
 None
 1.32A 2w26A-2zvbA:
undetectable		 2w26A-2zvbA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 4 TYR A 202
LEU A 200
LEU A 199
HIS A 169
 None
 1.50A 2x7hB-2zvbA:
undetectable		 2x7hB-2zvbA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 ALA A 134
VAL A 178
LEU A 154
ALA A 196
LEU A 230
 None
 1.29A 3ozuA-2zvbA:
undetectable		 3ozuA-2zvbA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 GLY A  12
GLY A  10
LEU A  14
THR A  36
LEU A  40
 None
 1.16A 3p2kB-2zvbA:
undetectable		 3p2kB-2zvbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 VAL A  80
TYR A  37
GLY A 130
GLY A  16
 None
 0.76A 5e26C-2zvbA:
undetectable
5e26D-2zvbA:
1.5		 5e26C-2zvbA:
24.28
5e26D-2zvbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 10 ALA A  28
ALA A  24
VAL A   7
LEU A  47
VAL A  80
 None
 1.26A 5eb5B-2zvbA:
undetectable		 5eb5B-2zvbA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 ALA A  67
ALA A  64
LEU A  79
GLY A  33
TYR A  34
 None
 1.17A 5igpA-2zvbA:
undetectable		 5igpA-2zvbA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 ILE A 243
LEU A 227
VAL A 178
ASP A 175
GLY A 172
 None
 1.14A 5nnaA-2zvbA:
undetectable		 5nnaA-2zvbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 ILE A 243
LEU A 227
VAL A 178
ASP A 175
GLY A 172
 None
 1.16A 5nnaB-2zvbA:
undetectable		 5nnaB-2zvbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 ILE A 243
LEU A 227
VAL A 178
ASP A 175
GLY A 172
 None
 1.16A 5nnaC-2zvbA:
undetectable		 5nnaC-2zvbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 ILE A 243
LEU A 227
VAL A 178
ASP A 175
GLY A 172
 None
 1.15A 5nnaD-2zvbA:
undetectable		 5nnaD-2zvbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		5 / 12 GLY A  82
SER A  81
GLU A  43
LEU A  41
GLU A  42
 SAH  A 301 (-4.8A)
None
None
None
None
 1.22A 5nwuA-2zvbA:
undetectable		 5nwuA-2zvbA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 VAL A 177
GLY A 142
LEU A 141
THR A 254
 None
 0.97A 5sxtA-2zvbA:
undetectable		 5sxtA-2zvbA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E
(Thermus
thermophilus) 		4 / 8 VAL A 177
GLY A 142
LEU A 141
THR A 254
 None
 0.97A 5sxtB-2zvbA:
undetectable		 5sxtB-2zvbA:
18.88