SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 289
SER A 300
ALA A 266
GLY A 125
THR A 332
 None
 1.01A 1gtnL-2zviA:
undetectable
1gtnV-2zviA:
undetectable		 1gtnL-2zviA:
10.43
1gtnV-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 SER A 337
VAL A 335
SER A 300
ASN A 292
 None
 1.26A 1hwiB-2zviA:
4.7		 1hwiB-2zviA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 SER A 337
VAL A 335
SER A 300
ASN A 292
 None
 1.25A 1hwkA-2zviA:
4.6		 1hwkA-2zviA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 SER A 337
VAL A 335
SER A 300
ASN A 292
 None
 1.25A 1hwkC-2zviA:
2.5		 1hwkC-2zviA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 SER A 337
VAL A 335
SER A 300
ASN A 292
 None
 1.25A 1hwkD-2zviA:
4.6		 1hwkD-2zviA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 SER A 116
PHE A 115
TYR A 294
LEU A  95
LEU A 110
 None
 1.47A 1p33A-2zviA:
undetectable		 1p33A-2zviA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 125
THR A 332
GLY A 289
SER A 300
ALA A 266
 None
 0.97A 1utdL-2zviA:
0.5
1utdM-2zviA:
undetectable		 1utdL-2zviA:
10.43
1utdM-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 125
THR A 332
GLY A 289
SER A 300
ALA A 266
 None
 1.00A 1utdO-2zviA:
undetectable
1utdP-2zviA:
undetectable		 1utdO-2zviA:
10.43
1utdP-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 11 GLY A 125
THR A 332
GLY A 289
SER A 300
ALA A 266
 None
 1.02A 1utdP-2zviA:
undetectable
1utdQ-2zviA:
0.5		 1utdP-2zviA:
10.43
1utdQ-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 5 LEU A  95
LEU A 286
LEU A 288
LEU A 110
 None
 1.14A 1yajD-2zviA:
undetectable		 1yajD-2zviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 5 LEU A 224
LEU A 239
LEU A 240
LEU A 254
 None
 1.15A 1yajD-2zviA:
undetectable		 1yajD-2zviA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 170
GLN A 166
GLY A 366
HIS A 367
LEU A 169
 None
 1.16A 3eeyB-2zviA:
undetectable		 3eeyB-2zviA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 ALA A 360
ILE A 358
ASN A 359
PRO A 143
 None
 0.99A 3fxrA-2zviA:
undetectable		 3fxrA-2zviA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 GLY A 375
GLY A 374
ALA A 404
ALA A 360
ALA A 380
 None
 0.97A 3jb2A-2zviA:
undetectable		 3jb2A-2zviA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 ILE A 193
ALA A 187
ALA A 214
VAL A 215
ASN A 216
 None
 1.08A 3jb3A-2zviA:
undetectable		 3jb3A-2zviA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 11 ASN A 216
LEU A 240
LEU A 301
VAL A 335
ILE A 148
 None
 1.23A 3jw5A-2zviA:
undetectable		 3jw5A-2zviA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 PHE A 115
CYH A 295
LEU A 248
ASP A 249
 None
 1.06A 3m0wE-2zviA:
undetectable
3m0wF-2zviA:
undetectable
3m0wG-2zviA:
undetectable
3m0wH-2zviA:
undetectable		 3m0wE-2zviA:
13.99
3m0wF-2zviA:
13.99
3m0wG-2zviA:
13.99
3m0wH-2zviA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 5 ASN A 359
ASP A 178
THR A 218
SER A 337
 None
 1.29A 3p2kC-2zviA:
undetectable		 3p2kC-2zviA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 7 LEU A 301
ALA A 297
GLY A 129
ILE A 133
 None
 0.65A 3spkB-2zviA:
undetectable		 3spkB-2zviA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 10 LEU A 301
ALA A 297
GLY A 129
ILE A 133
VAL A 335
 None
 0.86A 4dqbB-2zviA:
undetectable		 4dqbB-2zviA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 10 LEU A 301
ALA A 297
GLY A 129
ILE A 133
VAL A 335
 None
 0.83A 4dqeB-2zviA:
undetectable		 4dqeB-2zviA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 10 LEU A 301
ALA A 297
GLY A 129
ILE A 133
VAL A 335
 None
 0.89A 4dqhB-2zviA:
undetectable		 4dqhB-2zviA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 6 ARG A 192
GLY A 196
ALA A 231
GLN A 167
 None
 1.03A 4g0uA-2zviA:
undetectable		 4g0uA-2zviA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 GLY A 125
ALA A 328
LYS A 120
TYR A 294
 None
 0.89A 4hyfC-2zviA:
undetectable		 4hyfC-2zviA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		3 / 3 PRO A  46
LEU A  45
HIS A  56
 None
 0.67A 4pevA-2zviA:
2.2		 4pevA-2zviA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 7 PHE A 115
SER A 116
ALA A 122
LEU A 123
 None
 1.11A 4xk8A-2zviA:
undetectable		 4xk8A-2zviA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 12 LEU A 288
ASN A 292
LEU A 248
GLY A 296
SER A 271
 None
 1.47A 4zbrA-2zviA:
undetectable		 4zbrA-2zviA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 7 GLY A 272
PHE A 274
LEU A 287
GLU A 179
 None
 0.85A 5izfA-2zviA:
undetectable		 5izfA-2zviA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		4 / 8 ILE A 160
GLN A 163
ILE A 199
THR A 203
 None
 1.01A 6cduG-2zviA:
undetectable
6cduH-2zviA:
undetectable		 6cduG-2zviA:
20.60
6cduH-2zviA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 11 ASP A 112
LEU A  94
GLN A 252
GLY A 125
LEU A  13
 None
 1.18A 6euqA-2zviA:
0.0		 6euqA-2zviA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE
(Bacillus
subtilis) 		5 / 11 ASP A 112
LEU A  94
GLN A 252
GLY A 296
LEU A  13
 None
 1.21A 6euqA-2zviA:
0.0		 6euqA-2zviA:
23.71