SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		3 / 3 GLN A 157
HIS A 166
PRO A 165
 None
 0.97A 1d8cA-2zw4A:
undetectable		 1d8cA-2zw4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		4 / 5 ALA A 113
TRP A  97
LEU A  98
ALA A 112
 None
COA  A 401 (-4.3A)
COA  A 401 ( 4.5A)
None
 1.23A 2jstA-2zw4A:
undetectable
2jstB-2zw4A:
undetectable		 2jstA-2zw4A:
12.46
2jstB-2zw4A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		5 / 12 ALA A 212
PRO A 217
THR A 209
LEU A 200
VAL A 201
 None
 1.21A 2zifB-2zw4A:
undetectable		 2zifB-2zw4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		4 / 8 ILE A 287
THR A 197
LEU A 200
ALA A 222
 None
 0.87A 3hrdA-2zw4A:
undetectable
3hrdB-2zw4A:
undetectable		 3hrdA-2zw4A:
20.19
3hrdB-2zw4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		4 / 4 PRO A 226
THR A 225
GLY A 255
THR A 256
 None
 1.11A 3ib1A-2zw4A:
undetectable		 3ib1A-2zw4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		4 / 5 ALA A 269
ALA A 204
ILE A 287
LEU A 295
 None
 0.70A 5jncD-2zw4A:
undetectable		 5jncD-2zw4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		4 / 7 TYR A  58
TYR A  35
TRP A  44
HIS A 161
 None
 1.48A 5ov9B-2zw4A:
undetectable		 5ov9B-2zw4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		4 / 8 LEU A  19
VAL A 116
HIS A 119
LEU A  22
 None
 1.01A 5v0vA-2zw4A:
undetectable		 5v0vA-2zw4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2zw4 BLEOMYCIN
ACETYLTRANSFERASE
(Streptomyces
verticillus) 		5 / 10 ALA A 144
LEU A 149
VAL A 147
VAL A 129
ALA A 120
 None
 1.37A 6h1lA-2zw4A:
undetectable		 6h1lA-2zw4A:
20.99