SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 480
HIS A 443
MET A 403
 None
 1.43A 1l5qB-2zwaA:
2.8		 1l5qB-2zwaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 THR A 684
GLU A 383
ASP A 422
 None
 0.84A 1nt2A-2zwaA:
8.6		 1nt2A-2zwaA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		7 / 12 ILE A  27
GLN A  28
THR A  30
GLY A 115
GLY A 117
LEU A 197
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.7A)
None
 0.42A 1rjdA-2zwaA:
31.5		 1rjdA-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		6 / 6 ARG A  88
ASP A 146
TYR A 147
ASP A 196
ASN A 198
GLU A 224
 SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.9A)
SAH  A 801 (-3.0A)
 0.23A 1rjdA-2zwaA:
31.5		 1rjdA-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		7 / 12 ILE A  27
GLN A  28
THR A  30
GLY A 115
GLY A 117
LEU A 197
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.7A)
None
 0.42A 1rjdB-2zwaA:
31.4		 1rjdB-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		6 / 6 ARG A  88
ASP A 146
TYR A 147
ASP A 196
ASN A 198
GLU A 224
 SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.9A)
SAH  A 801 (-3.0A)
 0.24A 1rjdB-2zwaA:
31.4		 1rjdB-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		7 / 12 ILE A  27
GLN A  28
THR A  30
GLY A 115
GLY A 117
LEU A 197
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-3.7A)
None
 0.38A 1rjdC-2zwaA:
31.5		 1rjdC-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		6 / 6 ARG A  88
ASP A 146
TYR A 147
ASP A 196
ASN A 198
GLU A 224
 SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.9A)
SAH  A 801 (-3.0A)
 0.23A 1rjdC-2zwaA:
31.5		 1rjdC-2zwaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 228
TYR A 229
LEU A 227
GLY A 115
 None
None
None
SAH  A 801 (-3.5A)
 0.84A 1rukH-2zwaA:
undetectable
1rukL-2zwaA:
undetectable		 1rukH-2zwaA:
14.62
1rukL-2zwaA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 339
LEU A 253
PHE A 336
SER A 315
 None
 1.12A 1wrkB-2zwaA:
undetectable		 1wrkB-2zwaA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 339
LEU A 253
PHE A 336
SER A 315
 None
 1.19A 1wrlE-2zwaA:
undetectable		 1wrlE-2zwaA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 629
PHE A 595
LEU A 556
ILE A 554
 None
 0.71A 2azxA-2zwaA:
undetectable		 2azxA-2zwaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 542
ALA A 570
LEU A 590
LEU A 631
LEU A 506
 None
 1.12A 2bxqA-2zwaA:
undetectable		 2bxqA-2zwaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_B_SALB3006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 193
PHE A 184
THR A 186
ALA A 192
 None
 1.44A 2e1qB-2zwaA:
0.0		 2e1qB-2zwaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 193
PHE A 184
THR A 186
ALA A 192
 None
 1.44A 2e1qD-2zwaA:
undetectable		 2e1qD-2zwaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 227
LEU A 114
LEU A 206
MET A 245
 None
 1.10A 2oaxF-2zwaA:
undetectable		 2oaxF-2zwaA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 117
ASP A 146
ASP A 196
LEU A 197
 SAH  A 801 (-3.4A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.7A)
 0.22A 2uyqA-2zwaA:
20.9		 2uyqA-2zwaA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 239
ALA A 241
LEU A 207
LEU A 197
PHE A 250
 None
None
None
SAH  A 801 (-3.7A)
None
 1.02A 2w9sD-2zwaA:
2.3		 2w9sD-2zwaA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 239
ALA A 241
LEU A 207
LEU A 197
PHE A 250
 None
None
None
SAH  A 801 (-3.7A)
None
 1.08A 2w9sF-2zwaA:
undetectable		 2w9sF-2zwaA:
11.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		12 / 12 ILE A  27
GLN A  28
ASN A  31
SER A  34
GLY A 115
GLY A 117
ASP A 119
TYR A 147
LEU A 197
ASN A 198
TYR A 229
MET A 230
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-4.6A)
SAH  A 801 (-3.6A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 ( 4.3A)
SAH  A 801 (-3.8A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.9A)
None
SAH  A 801 ( 3.8A)
 0.28A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  27
GLN A  28
GLY A 117
TYR A 147
TYR A 229
 SAH  A 801 (-4.4A)
None
SAH  A 801 (-3.4A)
SAH  A 801 (-3.8A)
None
 1.16A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		8 / 8 THR A  30
LYS A  38
ARG A  88
ASP A 146
LEU A 150
ASP A 196
GLU A 224
SER A 226
 SAH  A 801 (-4.5A)
SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.6A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.0A)
SAH  A 801 (-4.6A)
 0.23A 2zw9A-2zwaA:
59.3		 2zw9A-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		12 / 12 GLN A  28
THR A  30
GLY A 115
GLY A 117
ASP A 119
LEU A 150
ASP A 196
LEU A 197
ASN A 198
GLU A 224
TYR A 229
MET A 230
 None
SAH  A 801 (-4.5A)
SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 ( 4.3A)
SAH  A 801 (-4.6A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.9A)
SAH  A 801 (-3.0A)
None
SAH  A 801 ( 3.8A)
 0.31A 2zw9B-2zwaA:
56.8		 2zw9B-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 115
ASP A 119
LEU A 151
ASP A 196
LEU A 197
ASN A 198
 SAH  A 801 (-3.5A)
SAH  A 801 ( 4.3A)
None
SAH  A 801 (-4.1A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.9A)
 1.28A 2zw9B-2zwaA:
56.8		 2zw9B-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 115
GLY A 117
ASP A 119
LEU A 150
ASP A  24
GLU A 224
 SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 ( 4.3A)
SAH  A 801 (-4.6A)
None
SAH  A 801 (-3.0A)
 1.37A 2zw9B-2zwaA:
56.8		 2zw9B-2zwaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		8 / 8 ILE A  27
ASN A  31
SER A  34
LYS A  38
ARG A  88
ASP A 146
TYR A 147
SER A 226
 SAH  A 801 (-4.4A)
SAH  A 801 (-4.6A)
SAH  A 801 (-3.6A)
SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
SAH  A 801 (-3.8A)
SAH  A 801 (-4.6A)
 0.31A 2zw9B-2zwaA:
56.8		 2zw9B-2zwaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  95
VAL A  41
LEU A 121
LEU A  64
 None
 0.96A 3gp0A-2zwaA:
2.2		 3gp0A-2zwaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 556
GLY A 599
ILE A 555
SER A 494
LEU A 506
 None
 1.32A 3gyqA-2zwaA:
2.1
3gyqB-2zwaA:
2.3		 3gyqA-2zwaA:
18.14
3gyqB-2zwaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 314
ASP A 308
ASP A 363
 None
 0.77A 3jb2A-2zwaA:
8.4		 3jb2A-2zwaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 SER A 315
PHE A 360
LEU A  96
SER A  94
ILE A  99
 None
 1.27A 3ko0C-2zwaA:
undetectable
3ko0D-2zwaA:
undetectable
3ko0E-2zwaA:
0.0
3ko0F-2zwaA:
undetectable		 3ko0C-2zwaA:
9.21
3ko0D-2zwaA:
9.21
3ko0E-2zwaA:
9.21
3ko0F-2zwaA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  96
SER A  94
ILE A  99
SER A 315
PHE A 360
 None
 1.23A 3ko0M-2zwaA:
undetectable
3ko0N-2zwaA:
undetectable
3ko0O-2zwaA:
undetectable
3ko0P-2zwaA:
undetectable		 3ko0M-2zwaA:
9.21
3ko0N-2zwaA:
9.21
3ko0O-2zwaA:
9.21
3ko0P-2zwaA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  93
ILE A  92
LEU A 312
THR A 320
 None
 1.25A 3nxuA-2zwaA:
undetectable		 3nxuA-2zwaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 115
GLY A 117
ASP A 196
LEU A 197
GLU A 224
TYR A 229
 SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.0A)
None
 0.56A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  38
ARG A  88
ASP A 144
 SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
None
 1.25A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  38
ARG A  88
ASP A 146
 SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
 0.31A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 117
ASP A 146
ASP A 196
 SAH  A 801 (-3.4A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
 0.33A 3ou7C-2zwaA:
11.1		 3ou7C-2zwaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 145
GLN A  28
LEU A 114
LEU A 207
 None
 0.86A 3ozwA-2zwaA:
undetectable		 3ozwA-2zwaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 598
LEU A 590
ARG A 597
 None
 0.81A 3sufB-2zwaA:
undetectable		 3sufB-2zwaA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 SER A  34
ASP A 146
ASP A 196
 SAH  A 801 (-3.6A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
 0.86A 3uj7A-2zwaA:
12.8		 3uj7A-2zwaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 443
TYR A 402
GLY A 405
LEU A 655
GLY A 615
 None
None
None
EDO  A 697 (-4.0A)
EDO  A 697 (-4.8A)
 1.24A 4blvB-2zwaA:
9.8		 4blvB-2zwaA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 301
THR A 242
ILE A 239
PHE A 296
 None
 0.84A 4ejjA-2zwaA:
undetectable		 4ejjA-2zwaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 647
LEU A 688
LYS A 389
GLY A 673
 None
 1.02A 4hajA-2zwaA:
undetectable		 4hajA-2zwaA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 499
ILE A 554
LEU A 504
LEU A 506
GLY A 543
 None
 1.23A 4l9qB-2zwaA:
undetectable		 4l9qB-2zwaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 SER A  34
ASP A 146
ASP A 196
 SAH  A 801 (-3.6A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
 0.82A 4mwzA-2zwaA:
12.2		 4mwzA-2zwaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 392
VAL A 395
ASP A 394
ALA A 495
 None
 1.06A 4nedA-2zwaA:
undetectable		 4nedA-2zwaA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 257
GLN A 268
LEU A 270
ALA A 271
LEU A 621
 None
 1.16A 4nqaA-2zwaA:
undetectable		 4nqaA-2zwaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 558
PHE A 534
ILE A 555
PHE A 535
 None
 0.98A 4qogA-2zwaA:
undetectable
4qogB-2zwaA:
undetectable		 4qogA-2zwaA:
15.25
4qogB-2zwaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 164
PHE A  69
ILE A  35
PHE A  70
 None
 1.08A 4y4dA-2zwaA:
undetectable		 4y4dA-2zwaA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 247
THR A 103
PRO A 104
VAL A 218
 None
 0.95A 4yoaA-2zwaA:
undetectable		 4yoaA-2zwaA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 265
LEU A 256
ASN A 287
PRO A 258
 None
 1.38A 4yv5B-2zwaA:
undetectable		 4yv5B-2zwaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 265
LEU A 256
ASN A 287
PRO A 258
 None
 1.37A 4yv5A-2zwaA:
undetectable		 4yv5A-2zwaA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 492
GLN A 563
LEU A 333
GLU A 332
 None
 1.07A 4zphA-2zwaA:
undetectable
4zphB-2zwaA:
0.0		 4zphA-2zwaA:
20.63
4zphB-2zwaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 324
SER A  94
ASN A  53
TYR A  45
LEU A  49
 None
 1.10A 5czyA-2zwaA:
undetectable		 5czyA-2zwaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 379
ILE A 629
GLY A 614
LEU A 660
 None
 0.87A 5eseA-2zwaA:
undetectable		 5eseA-2zwaA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 241
SER A 204
GLN A 292
ARG A 234
LEU A 227
 None
 1.42A 5m54B-2zwaA:
undetectable		 5m54B-2zwaA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  95
ILE A  99
LEU A 125
ARG A  88
 None
None
None
SAH  A 801 (-3.9A)
 1.04A 5vc0A-2zwaA:
undetectable		 5vc0A-2zwaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 420
MET A 426
ASN A 398
VAL A 400
 None
 1.40A 5xdhD-2zwaA:
undetectable		 5xdhD-2zwaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  90
ARG A  88
LEU A  87
ALA A 316
 None
SAH  A 801 (-3.9A)
None
None
 1.06A 6b89B-2zwaA:
2.4		 6b89B-2zwaA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 197
SER A 200
PHE A 203
 SAH  A 801 (-3.7A)
None
None
 0.64A 6fgcA-2zwaA:
undetectable		 6fgcA-2zwaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2
(Saccharomyces
cerevisiae) 		5 / 5 ILE A 554
LEU A 556
ARG A 608
THR A 637
LEU A 638
 None
 1.44A 6nmpN-2zwaA:
undetectable
6nmpW-2zwaA:
undetectable		 6nmpN-2zwaA:
20.73
6nmpW-2zwaA:
6.71