SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 10 THR A 119
ALA A 122
PHE A 188
LEU A 223
ILE A 227
 None
 1.02A 1claA-2zwiA:
undetectable		 1claA-2zwiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 9 ALA A 151
GLU A 152
LEU A 209
ILE A 396
LEU A 387
 GOL  A   5 (-3.1A)
GOL  A   5 ( 4.8A)
GOL  A   7 (-4.5A)
None
None
 1.50A 1ereB-2zwiA:
undetectable		 1ereB-2zwiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 9 ALA A 151
GLU A 152
LEU A 209
ILE A 396
LEU A 387
 GOL  A   5 (-3.1A)
GOL  A   5 ( 4.8A)
GOL  A   7 (-4.5A)
None
None
 1.49A 1ereD-2zwiA:
undetectable		 1ereD-2zwiA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 4 GLY A 149
SER A 360
VAL A 154
LEU A 120
 GOL  A   5 (-3.4A)
C5P  A   1 ( 2.6A)
None
None
 1.13A 1yajB-2zwiA:
2.2		 1yajB-2zwiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 10 ILE A 276
GLY A 277
ILE A 291
LEU A 292
PHE A 373
 C5P  A   1 (-4.0A)
C5P  A   1 (-4.0A)
None
None
None
 1.11A 1z11C-2zwiA:
undetectable		 1z11C-2zwiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 8 LEU A  50
SER A 360
LEU A 209
GLU A 152
 None
C5P  A   1 ( 2.6A)
GOL  A   7 (-4.5A)
GOL  A   5 ( 4.8A)
 0.73A 2j2pA-2zwiA:
undetectable
2j2pB-2zwiA:
undetectable		 2j2pA-2zwiA:
19.94
2j2pB-2zwiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 5 PHE A 373
SER A 364
PHE A 275
ILE A 345
 None
 1.31A 2v0mD-2zwiA:
undetectable		 2v0mD-2zwiA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 8 GLY A 277
HIS A 317
ILE A 327
ALA A 283
 C5P  A   1 (-4.0A)
C5P  A   1 (-4.0A)
None
None
 0.94A 2x0pA-2zwiA:
undetectable		 2x0pA-2zwiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 5 GLN A 325
ALA A 285
GLN A 288
ILE A 289
 None
 1.32A 2z0aA-2zwiA:
undetectable		 2z0aA-2zwiA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 12 GLY A 117
ARG A  47
VAL A  43
ILE A 128
ASN A 127
 None
 1.28A 3jb2A-2zwiA:
2.8		 3jb2A-2zwiA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		3 / 3 GLN A  58
THR A  57
LEU A 209
 None
None
GOL  A   7 (-4.5A)
 0.75A 3ondA-2zwiA:
undetectable		 3ondA-2zwiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		3 / 3 GLN A  58
THR A  57
LEU A 209
 None
None
GOL  A   7 (-4.5A)
 0.76A 3ondB-2zwiA:
3.4		 3ondB-2zwiA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 6 VAL A 402
ASN A 398
TYR A 376
ILE A 396
 None
 1.23A 3q5sA-2zwiA:
undetectable		 3q5sA-2zwiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 8 LEU A 156
MET A 208
TYR A 206
GLU A 152
 None
None
None
GOL  A   5 ( 4.8A)
 1.02A 3zmdA-2zwiA:
undetectable
3zmdB-2zwiA:
undetectable		 3zmdA-2zwiA:
16.17
3zmdB-2zwiA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 12 TYR A 251
PHE A 250
ILE A 339
LYS A 262
ILE A 261
 None
 1.10A 4nnrA-2zwiA:
undetectable
4nnrB-2zwiA:
undetectable		 4nnrA-2zwiA:
16.03
4nnrB-2zwiA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 10 TYR A 251
PHE A 250
ILE A 339
LYS A 262
ILE A 261
 None
 1.08A 4nnrB-2zwiA:
undetectable		 4nnrB-2zwiA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 8 ILE A 227
LYS A 224
ILE A 231
ALA A 211
 None
 0.88A 4ou1A-2zwiA:
undetectable		 4ou1A-2zwiA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 12 TYR A 376
VAL A 361
SER A 359
ILE A 276
VAL A 369
 None
C5P  A   1 (-4.8A)
C5P  A   1 (-2.6A)
C5P  A   1 (-4.0A)
None
 1.49A 4rujA-2zwiA:
undetectable		 4rujA-2zwiA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		3 / 3 THR A 304
ASN A 305
SER A 306
 None
 0.77A 4tvtA-2zwiA:
undetectable		 4tvtA-2zwiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		3 / 3 TYR A 238
TYR A 146
GLN A  54
 None
 1.11A 5jsdA-2zwiA:
undetectable
5jsdB-2zwiA:
undetectable		 5jsdA-2zwiA:
19.48
5jsdB-2zwiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		3 / 3 TYR A 238
TYR A 146
GLN A  54
 None
 1.11A 5jsdB-2zwiA:
undetectable
5jsdC-2zwiA:
undetectable		 5jsdB-2zwiA:
19.48
5jsdC-2zwiA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		4 / 8 SER A 180
SER A 181
ASP A 189
SER A 191
 None
 1.13A 5l5fY-2zwiA:
undetectable
5l5fZ-2zwiA:
undetectable		 5l5fY-2zwiA:
19.95
5l5fZ-2zwiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 12 LEU A 344
GLY A 316
LEU A 292
ILE A 276
MET A 332
 None
C5P  A   1 (-4.3A)
None
C5P  A   1 (-4.0A)
None
 1.20A 5y2tA-2zwiA:
undetectable		 5y2tA-2zwiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 12 LEU A 344
ILE A 335
GLY A 316
LEU A 292
ILE A 276
 None
None
C5P  A   1 (-4.3A)
None
C5P  A   1 (-4.0A)
 1.00A 5ycnA-2zwiA:
undetectable		 5ycnA-2zwiA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6U_D_FYPD410_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2)		 2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE
(Photobacterium
phosphoreum) 		5 / 9 SER A 359
SER A 360
ASP A 148
ALA A  48
THR A  49
 C5P  A   1 (-2.6A)
C5P  A   1 ( 2.6A)
GOL  A   5 (-3.5A)
None
C5P  A   1 (-4.1A)
 1.18A 6d6uD-2zwiA:
0.0
6d6uE-2zwiA:
0.0		 6d6uD-2zwiA:
20.43
6d6uE-2zwiA:
21.80