SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2zwk PUTATIVE
TRANSLOCATED INTIMIN
RECEPTOR PROTEIN
(TRANSLOCATED
INTIMIN RECEPTOR
TIR)
(Escherichia
coli) 		4 / 5 ILE B  37
ASN B  35
ILE B  30
ASP B  31
 None
 1.02A 2h4jA-2zwkB:
undetectable		 2h4jA-2zwkB:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 2zwk INTIMIN
PUTATIVE
TRANSLOCATED INTIMIN
RECEPTOR PROTEIN
(TRANSLOCATED
INTIMIN RECEPTOR
TIR)
(Escherichia
coli;
Escherichia
coli) 		5 / 10 THR A 179
PRO A 180
LEU A 172
THR A 146
GLY B  34
 None
 1.00A 2vl2A-2zwkA:
undetectable
2vl2C-2zwkA:
undetectable		 2vl2A-2zwkA:
21.65
2vl2C-2zwkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2zwk INTIMIN
PUTATIVE
TRANSLOCATED INTIMIN
RECEPTOR PROTEIN
(TRANSLOCATED
INTIMIN RECEPTOR
TIR)
(Escherichia
coli;
Escherichia
coli) 		5 / 12 ALA B  36
SER A 162
PRO A 173
GLY A 174
GLN A 120
 None
 0.97A 3douA-2zwkB:
undetectable		 3douA-2zwkB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2zwk INTIMIN
(Escherichia
coli) 		4 / 8 GLY A  70
ASN A  69
PRO A  93
ILE A  90
 None
 0.93A 4j4vC-2zwkA:
undetectable		 4j4vC-2zwkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2zwk INTIMIN
(Escherichia
coli) 		3 / 3 ARG A  24
LYS A  38
LYS A  40
 None
 1.35A 4k50A-2zwkA:
undetectable		 4k50A-2zwkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2zwk INTIMIN
(Escherichia
coli) 		3 / 3 ARG A  24
LYS A  38
LYS A  40
 None
 1.32A 4k50E-2zwkA:
undetectable		 4k50E-2zwkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2zwk INTIMIN
(Escherichia
coli) 		3 / 3 ARG A  24
LYS A  38
LYS A  40
 None
 1.36A 4k50I-2zwkA:
undetectable		 4k50I-2zwkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2zwk INTIMIN
(Escherichia
coli) 		4 / 7 GLU A 155
SER A 161
ILE A 149
LYS A 150
 None
 1.03A 4tvtA-2zwkA:
undetectable		 4tvtA-2zwkA:
18.39