SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 HIS A  54
HIS A  56
PHE A  57
ASP A 144
LEU A  11
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
None
ZN  A 208 ( 2.5A)
None
 1.23A 1c3sA-2zwrA:
undetectable		 1c3sA-2zwrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 ASP A  58
HIS A  59
HIS A 125
ASP A 144
HIS A 184
 ZN  A 208 (-2.7A)
ZN  A 208 (-3.2A)
ZN  A 209 (-3.3A)
ZN  A 208 ( 2.5A)
ZN  A 208 (-3.2A)
 0.55A 2q0jB-2zwrA:
17.8		 2q0jB-2zwrA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A 192
ASN A 197
ARG A 148
 None
 0.96A 2qhfA-2zwrA:
undetectable		 2qhfA-2zwrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.75A 3abkA-2zwrA:
undetectable		 3abkA-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.74A 3abkN-2zwrA:
undetectable		 3abkN-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.70A 3ag2A-2zwrA:
undetectable		 3ag2A-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.74A 3ag2N-2zwrA:
undetectable		 3ag2N-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.74A 3ag3A-2zwrA:
undetectable		 3ag3A-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.74A 3ag3N-2zwrA:
undetectable		 3ag3N-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.69A 3ag4A-2zwrA:
undetectable		 3ag4A-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.74A 3ag4N-2zwrA:
undetectable		 3ag4N-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.75A 3asnA-2zwrA:
undetectable		 3asnA-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.75A 3asoA-2zwrA:
undetectable		 3asoA-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 155
HIS A  54
HIS A 125
ASP A  58
 None
ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
ZN  A 208 (-2.7A)
 0.84A 3c0zC-2zwrA:
undetectable		 3c0zC-2zwrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 147
SER A 150
THR A  53
TYR A  16
THR A 188
 None
 1.16A 3hj3C-2zwrA:
undetectable		 3hj3C-2zwrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 5 VAL A  74
PHE A 132
ILE A  27
PHE A 141
 None
 1.09A 3owxB-2zwrA:
undetectable		 3owxB-2zwrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 12 ASP A  58
ILE A  27
ASP A  28
ASP A 144
PHE A 147
 ZN  A 208 (-2.7A)
None
None
ZN  A 208 ( 2.5A)
None
 1.36A 3topA-2zwrA:
undetectable		 3topA-2zwrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A 180
PHE A 147
THR A  53
TYR A  16
THR A 188
 None
 0.81A 3um5A-2zwrA:
undetectable		 3um5A-2zwrA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A 180
PHE A 147
THR A  53
TYR A  16
THR A 188
 None
 0.86A 3um5B-2zwrA:
undetectable		 3um5B-2zwrA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 7 SER A 126
GLU A  13
HIS A  59
HIS A  56
 None
None
ZN  A 208 (-3.2A)
ZN  A 209 (-3.2A)
 1.27A 4aq7A-2zwrA:
undetectable		 4aq7A-2zwrA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 10 HIS A  54
HIS A  56
ASP A  58
HIS A 125
HIS A 184
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.75A 4c1dB-2zwrA:
5.8		 4c1dB-2zwrA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 11 HIS A  54
HIS A  56
ASP A  58
HIS A 125
HIS A 184
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.78A 4c1fA-2zwrA:
5.6
4c1fB-2zwrA:
5.4		 4c1fA-2zwrA:
24.58
4c1fB-2zwrA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 9 HIS A  54
HIS A  56
ASP A  58
HIS A 125
HIS A 184
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.73A 4c1hA-2zwrA:
5.5		 4c1hA-2zwrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 9 HIS A  56
ASP A  58
HIS A  54
GLY A 152
HIS A 184
 ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
None
ZN  A 208 (-3.2A)
 1.06A 4c1hA-2zwrA:
5.5		 4c1hA-2zwrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  56
ASP A  58
HIS A 125
HIS A 184
 ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.71A 4exsB-2zwrA:
18.2		 4exsB-2zwrA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A   5
GLU A  13
LEU A   8
LEU A  36
 None
 0.89A 4iomA-2zwrA:
undetectable		 4iomA-2zwrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 PRO A   5
GLU A  13
LEU A   8
LEU A  36
 None
 0.90A 4jjkA-2zwrA:
undetectable		 4jjkA-2zwrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  56
ASP A  58
HIS A 125
HIS A 184
 ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.75A 5a5zA-2zwrA:
4.8		 5a5zA-2zwrA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		6 / 11 HIS A  54
HIS A  56
ASP A  58
HIS A  59
HIS A 125
HIS A 184
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 208 (-3.2A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.36A 5ayaA-2zwrA:
17.3		 5ayaA-2zwrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.73A 5b3sA-2zwrA:
undetectable		 5b3sA-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 144
HIS A 125
HIS A  54
HIS A 184
 ZN  A 208 ( 2.5A)
ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.91A 5ncdA-2zwrA:
undetectable
5ncdD-2zwrA:
undetectable		 5ncdA-2zwrA:
23.74
5ncdD-2zwrA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 144
HIS A 125
HIS A  54
HIS A 184
 ZN  A 208 ( 2.5A)
ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.89A 5ncdB-2zwrA:
undetectable
5ncdC-2zwrA:
undetectable		 5ncdB-2zwrA:
23.74
5ncdC-2zwrA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 ASP A 144
HIS A 125
HIS A  54
HIS A 184
 ZN  A 208 ( 2.5A)
ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.85A 5nekD-2zwrA:
undetectable		 5nekD-2zwrA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 144
HIS A 125
HIS A  54
HIS A 184
 ZN  A 208 ( 2.5A)
ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.92A 5nelA-2zwrA:
undetectable
5nelD-2zwrA:
undetectable		 5nelA-2zwrA:
23.74
5nelD-2zwrA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		5 / 10 HIS A  54
HIS A  56
HIS A  59
HIS A 125
ASP A 144
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.2A)
ZN  A 208 (-3.2A)
ZN  A 209 (-3.3A)
ZN  A 208 ( 2.5A)
 0.45A 5nzwA-2zwrA:
6.0		 5nzwA-2zwrA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.72A 5waua-2zwrA:
undetectable		 5waua-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 125
HIS A  54
HIS A 129
 ZN  A 209 (-3.3A)
ZN  A 209 (-3.3A)
None
 0.72A 5x19A-2zwrA:
undetectable		 5x19A-2zwrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  56
ASP A  58
HIS A  54
HIS A 184
 ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 1.03A 5zj8A-2zwrA:
18.5		 5zj8A-2zwrA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  56
ASP A  58
HIS A 125
HIS A 184
 ZN  A 209 (-3.2A)
ZN  A 208 (-2.7A)
ZN  A 209 (-3.3A)
ZN  A 208 (-3.2A)
 0.78A 5zj8A-2zwrA:
18.5		 5zj8A-2zwrA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  81
GLY A 128
PHE A 132
 None
 0.66A 6exiC-2zwrA:
undetectable		 6exiC-2zwrA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A 143
VAL A 151
GLY A 128
SER A 126
 None
 0.80A 6hu9H-2zwrA:
undetectable
6hu9e-2zwrA:
undetectable		 6hu9H-2zwrA:
15.20
6hu9e-2zwrA:
19.32