SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zxh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 4 THR A 321
PRO A 203
THR A 202
PRO A 316
None
None
FAD  A 618 (-4.3A)
None
1.42A 1a7yA-2zxhA:
undetectable
1a7yC-2zxhA:
undetectable
1a7yA-2zxhA:
2.33
1a7yC-2zxhA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 GLU A 217
ILE A 251
ARG A  97
None
0.85A 1cd2A-2zxhA:
undetectable
1cd2A-2zxhA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 9 LEU A 400
ASN A 397
LEU A 410
GLY A 391
ALA A  25
None
1.04A 1e7aA-2zxhA:
undetectable
1e7aA-2zxhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 11 VAL A 592
SER A 596
LEU A 559
TYR A 570
LEU A 610
None
1.13A 1eqgB-2zxhA:
undetectable
1eqgB-2zxhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 ALA A 451
ALA A  66
ALA A  25
ILE A 417
ILE A 392
None
0.89A 1fk6A-2zxhA:
undetectable
1fk6A-2zxhA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 ILE A 392
ASN A 397
LEU A 464
GLY A 459
MET A  29
None
1.30A 1hvyB-2zxhA:
undetectable
1hvyB-2zxhA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 GLY A 389
ILE A  52
GLY A  53
GLY A  58
ILE A  59
None
0.84A 1hxbA-2zxhA:
undetectable
1hxbA-2zxhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 8 ARG A 454
GLY A  58
VAL A  61
GLU A  63
SER A  95
None
1.48A 1pk7B-2zxhA:
undetectable
1pk7B-2zxhA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 10 ARG A  28
GLY A  72
SER A 229
ASP A  76
ILE A  75
None
1.47A 1pw7A-2zxhA:
undetectable
1pw7A-2zxhA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 THR A 366
GLY A 371
ILE A 369
VAL A 136
None
0.97A 1rxcB-2zxhA:
undetectable
1rxcB-2zxhA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 THR A 366
GLY A 371
ILE A 369
VAL A 136
None
0.97A 1rxcI-2zxhA:
undetectable
1rxcI-2zxhA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 THR A 366
GLY A 371
ILE A 369
VAL A 136
None
0.96A 1rxcK-2zxhA:
undetectable
1rxcK-2zxhA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 GLN A 301
ILE A 302
TYR A 253
None
0.65A 1vifA-2zxhA:
undetectable
1vifA-2zxhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 LEU A 410
LEU A  67
GLU A  21
GLY A 391
ALA A 394
None
1.14A 2bm9D-2zxhA:
3.1
2bm9D-2zxhA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 GLY A 391
GLY A  19
ASN A 397
ILE A 408
LEU A 458
None
1.10A 2hmyB-2zxhA:
undetectable
2hmyB-2zxhA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 ILE A 408
GLY A 395
MET A  29
ILE A 392
None
0.78A 2qwxA-2zxhA:
undetectable
2qwxB-2zxhA:
undetectable
2qwxA-2zxhA:
16.06
2qwxB-2zxhA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 LEU A 372
PHE A 187
THR A 149
ILE A 130
THR A 156
None
None
None
None
FAD  A 618 (-4.4A)
0.95A 2w3bA-2zxhA:
undetectable
2w3bA-2zxhA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 VAL A 393
ALA A 375
LEU A 424
LEU A 435
ILE A 417
None
1.08A 2w3vA-2zxhA:
undetectable
2w3vA-2zxhA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 10 GLU A 386
ILE A  52
GLY A  58
ILE A  64
MET A  71
FAD  A 618 ( 4.6A)
None
None
None
None
1.37A 3adsA-2zxhA:
undetectable
3adsA-2zxhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 SER A 596
ALA A 595
ILE A 606
LEU A 610
LEU A 613
None
1.20A 3adsB-2zxhA:
undetectable
3adsB-2zxhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 TYR A 433
GLU A  63
ASP A 449
None
0.74A 3bxoA-2zxhA:
undetectable
3bxoA-2zxhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 TYR A 433
GLU A  63
ASP A 449
None
0.81A 3bxoB-2zxhA:
undetectable
3bxoB-2zxhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 GLY A 376
GLY A 383
ASN A 397
VAL A 393
ILE A 421
FAD  A 618 (-3.3A)
FAD  A 618 (-2.9A)
None
None
None
0.99A 3eluA-2zxhA:
undetectable
3eluA-2zxhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 GLY A 376
GLY A 383
ASN A 397
VAL A 393
ILE A 421
FAD  A 618 (-3.3A)
FAD  A 618 (-2.9A)
None
None
None
1.01A 3embA-2zxhA:
undetectable
3embA-2zxhA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 11 GLU A  70
LEU A  24
ILE A  20
ASP A  76
SER A 229
None
1.48A 3ko0C-2zxhA:
undetectable
3ko0D-2zxhA:
undetectable
3ko0E-2zxhA:
0.0
3ko0F-2zxhA:
undetectable
3ko0C-2zxhA:
9.74
3ko0D-2zxhA:
9.74
3ko0E-2zxhA:
9.74
3ko0F-2zxhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 11 GLU A  70
LEU A  24
ILE A  20
ASP A  76
SER A 229
None
1.46A 3ko0E-2zxhA:
undetectable
3ko0F-2zxhA:
undetectable
3ko0G-2zxhA:
undetectable
3ko0H-2zxhA:
undetectable
3ko0E-2zxhA:
9.74
3ko0F-2zxhA:
9.74
3ko0G-2zxhA:
9.74
3ko0H-2zxhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
6 / 12 LEU A 455
GLY A 389
GLY A 376
GLY A 418
MET A 420
LEU A 424
None
None
FAD  A 618 (-3.3A)
None
None
None
1.49A 3ku1A-2zxhA:
2.9
3ku1A-2zxhA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 VAL A 592
SER A 596
LEU A 559
None
0.60A 3n8xA-2zxhA:
undetectable
3n8xA-2zxhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 7 LEU A 364
ALA A  22
GLY A  69
ILE A  64
None
0.84A 3spkB-2zxhA:
undetectable
3spkB-2zxhA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 TYR A 409
GLU A  63
TYR A 416
None
1.00A 3ug8A-2zxhA:
undetectable
3ug8A-2zxhA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 7 LEU A  67
ALA A  25
VAL A 153
ILE A 392
None
0.95A 3wsjB-2zxhA:
undetectable
3wsjB-2zxhA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 THR A 366
GLY A 371
ILE A 369
VAL A 136
None
1.00A 4e1vD-2zxhA:
undetectable
4e1vD-2zxhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 LEU A 372
PHE A 187
THR A 149
ILE A 130
THR A 156
None
None
None
None
FAD  A 618 (-4.4A)
0.96A 4kebB-2zxhA:
undetectable
4kebB-2zxhA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 LEU A 372
PHE A 187
THR A 149
ILE A 130
THR A 156
None
None
None
None
FAD  A 618 (-4.4A)
0.94A 4m6kA-2zxhA:
undetectable
4m6kA-2zxhA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 GLY A 162
ASP A 353
ILE A 171
GLY A 177
SER A 181
None
None
None
None
FAD  A 618 (-3.3A)
1.13A 4obwC-2zxhA:
undetectable
4obwC-2zxhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 VAL A  60
PHE A 228
GLY A  53
GLY A  72
ASP A  76
None
1.32A 4pevB-2zxhA:
3.8
4pevB-2zxhA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 ILE A 408
GLY A 395
MET A  29
ILE A 392
None
0.86A 4qogA-2zxhA:
2.0
4qogB-2zxhA:
undetectable
4qogA-2zxhA:
16.06
4qogB-2zxhA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
4 / 8 ALA A 375
GLY A 391
ALA A  22
GLY A  19
None
0.66A 4zjzA-2zxhA:
undetectable
4zjzA-2zxhA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
3 / 3 ASP A 128
LEU A 195
ARG A 189
None
0.94A 5e8qA-2zxhA:
undetectable
5e8qA-2zxhA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 PRO A 346
LEU A 343
GLY A 167
LEU A 271
MET A 331
None
1.27A 5emlA-2zxhA:
undetectable
5emlA-2zxhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 TYR A 105
GLY A 389
GLY A 383
GLY A  72
VAL A  61
None
None
FAD  A 618 (-2.9A)
None
None
0.97A 5i73A-2zxhA:
undetectable
5i73A-2zxhA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 PHE A 378
GLY A  14
THR A 382
GLU A 178
GLY A  16
None
FAD  A 618 (-3.3A)
FAD  A 618 (-3.5A)
None
FAD  A 618 (-3.0A)
1.03A 5veuH-2zxhA:
undetectable
5veuH-2zxhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 PHE A 240
GLY A 236
SER A 237
ARG A  62
ASP A  76
None
1.09A 5w7pA-2zxhA:
undetectable
5w7pA-2zxhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 11 ALA A  22
ALA A 375
ALA A 394
GLY A  15
GLY A  14
None
None
None
FAD  A 618 (-3.8A)
FAD  A 618 (-3.3A)
0.84A 6hwdK-2zxhA:
undetectable
6hwdL-2zxhA:
undetectable
6hwdK-2zxhA:
8.93
6hwdL-2zxhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 11 ALA A  22
ALA A 375
ALA A 394
GLY A  15
GLY A  14
None
None
None
FAD  A 618 (-3.8A)
FAD  A 618 (-3.3A)
0.85A 6hwdY-2zxhA:
undetectable
6hwdZ-2zxhA:
undetectable
6hwdY-2zxhA:
8.93
6hwdZ-2zxhA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus)
5 / 12 PRO A 316
LEU A 319
ILE A 287
GLY A 201
ALA A 270
None
None
None
FAD  A 618 (-4.0A)
None
1.10A 6qxsD-2zxhA:
undetectable
6qxsD-2zxhA:
18.56