SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 PRO A 108
HIS A 160
HIS A 161
ASP A 221
ASP A  82
 None
 1.25A 1c3sA-2zxoA:
undetectable		 1c3sA-2zxoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 8 GLU A 548
ARG A 552
LEU A 544
GLU A 602
 None
 0.93A 1cmaA-2zxoA:
undetectable
1cmaB-2zxoA:
undetectable		 1cmaA-2zxoA:
9.67
1cmaB-2zxoA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 GLY A 187
ALA A 188
VAL A 233
PRO A 207
ILE A  91
 None
 0.97A 1fb7A-2zxoA:
undetectable		 1fb7A-2zxoA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 10 GLY A 217
VAL A 216
LEU A 248
LEU A 288
ALA A 269
 None
 1.22A 1pbcA-2zxoA:
undetectable		 1pbcA-2zxoA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 LEU A  55
GLY A  85
GLY A  88
ILE A  91
VAL A 173
 None
 1.05A 1sduA-2zxoA:
undetectable		 1sduA-2zxoA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 LEU A 634
GLY A 535
GLY A 536
ILE A 537
PRO A 543
 None
 1.00A 1sduA-2zxoA:
undetectable		 1sduA-2zxoA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 ALA A 281
GLY A  88
GLY A  85
ILE A 107
ILE A  91
 None
 0.89A 1x1aA-2zxoA:
undetectable		 1x1aA-2zxoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 5 LEU A 131
GLY A  95
ALA A  68
ILE A  75
 None
 0.81A 2aohB-2zxoA:
undetectable		 2aohB-2zxoA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 7 ASP A 432
PHE A 462
ARG A 632
ALA A  31
 None
 1.26A 2e5dA-2zxoA:
undetectable
2e5dB-2zxoA:
undetectable		 2e5dA-2zxoA:
22.32
2e5dB-2zxoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A 589
GLY A 606
LEU A 587
LEU A 544
ALA A 549
 None
 1.04A 2egvA-2zxoA:
2.2		 2egvA-2zxoA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A 589
GLY A 606
LEU A 587
LEU A 544
ALA A 549
 None
 1.07A 2egvB-2zxoA:
2.4		 2egvB-2zxoA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.92A 2f8gB-2zxoA:
undetectable		 2f8gB-2zxoA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.88A 2ienA-2zxoA:
undetectable		 2ienA-2zxoA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.86A 2nmzB-2zxoA:
undetectable		 2nmzB-2zxoA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		3 / 3 PHE A 400
PHE A 410
PHE A 407
 None
 0.84A 2od9A-2zxoA:
6.5		 2od9A-2zxoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 10 LEU A  52
ARG A 201
PRO A 175
VAL A 173
GLY A  57
 None
 1.34A 2qd4B-2zxoA:
3.8		 2qd4B-2zxoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 ILE A 272
ALA A 269
GLY A 217
ASP A 212
GLY A  85
 None
 0.90A 2qe6A-2zxoA:
undetectable		 2qe6A-2zxoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		3 / 3 PHE A 400
PHE A 410
PHE A 407
 None
 0.84A 2qqgA-2zxoA:
6.5		 2qqgA-2zxoA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 4 LYS A 283
LEU A 306
ALA A 281
LEU A 278
 None
 1.44A 2roxA-2zxoA:
undetectable		 2roxA-2zxoA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		3 / 3 ARG A 612
GLU A 602
SER A 614
 None
 0.93A 2xkkA-2zxoA:
3.1
2xkkC-2zxoA:
3.0		 2xkkA-2zxoA:
25.00
2xkkC-2zxoA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 GLY A 456
GLY A 454
LEU A 450
ALA A 223
VAL A 222
 None
 1.19A 2yvlD-2zxoA:
3.2		 2yvlD-2zxoA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 GLY A 187
GLY A 217
ILE A 268
LEU A 288
LEU A 287
 None
 1.10A 2zbpA-2zxoA:
undetectable		 2zbpA-2zxoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 6 GLU A 459
ALA A  31
PRO A 460
ALA A  34
 None
 1.17A 2zgwB-2zxoA:
5.0		 2zgwB-2zxoA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 5 HIS A 160
HIS A 161
ASP A 221
ASP A  82
 None
 1.11A 3c0zA-2zxoA:
undetectable		 3c0zA-2zxoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 6 HIS A 160
HIS A 161
ASP A 221
ASP A  82
 None
 1.13A 3c0zC-2zxoA:
undetectable		 3c0zC-2zxoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.90A 3ektC-2zxoA:
undetectable		 3ektC-2zxoA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 6 ILE A 332
THR A 368
PHE A 400
PHE A 410
 None
 1.32A 3elzB-2zxoA:
undetectable		 3elzB-2zxoA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 9 LEU A  52
ARG A 201
PRO A 175
VAL A 173
GLY A  57
 None
 1.37A 3hcnB-2zxoA:
0.0		 3hcnB-2zxoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.88A 3jw2A-2zxoA:
undetectable		 3jw2A-2zxoA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.86A 3lzuB-2zxoA:
undetectable		 3lzuB-2zxoA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 LEU A 288
ILE A 272
ALA A 215
THR A 218
ALA A  83
 None
 1.05A 3mdtB-2zxoA:
undetectable		 3mdtB-2zxoA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.87A 3s54A-2zxoA:
undetectable		 3s54A-2zxoA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 HIS A 160
ALA A 220
ILE A  91
GLY A  85
GLY A  79
 None
 1.08A 4hfpB-2zxoA:
undetectable		 4hfpB-2zxoA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 HIS A  78
PRO A 108
HIS A 161
ASP A  82
GLY A  85
 None
 1.29A 4lxzB-2zxoA:
undetectable		 4lxzB-2zxoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 11 LEU A 131
LEU A 133
GLU A  66
LEU A  65
LEU A  96
 None
 1.23A 4wg0H-2zxoA:
undetectable
4wg0I-2zxoA:
undetectable
4wg0J-2zxoA:
undetectable		 4wg0H-2zxoA:
2.62
4wg0I-2zxoA:
2.62
4wg0J-2zxoA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 GLY A  85
LEU A 285
VAL A 135
VAL A  77
VAL A  93
 None
 1.14A 5dpdB-2zxoA:
3.2		 5dpdB-2zxoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.85A 5e5kB-2zxoA:
undetectable		 5e5kB-2zxoA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 ASP A 212
ALA A 211
THR A 158
PHE A 192
GLY A 187
 None
 1.30A 5hfjC-2zxoA:
2.4		 5hfjC-2zxoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		5 / 12 LEU A  92
GLY A 187
ALA A 188
PRO A 207
ILE A  91
 None
 0.88A 5t8hB-2zxoA:
undetectable		 5t8hB-2zxoA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 5 VAL A 190
HIS A 161
LEU A 133
ASP A  84
 None
 1.49A 5vcvA-2zxoA:
undetectable		 5vcvA-2zxoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 6 VAL A 601
LEU A 650
TYR A 560
LEU A 605
 None
 1.02A 6f6sA-2zxoA:
undetectable
6f6sB-2zxoA:
undetectable		 6f6sA-2zxoA:
8.78
6f6sB-2zxoA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 6 LEU A 605
ALA A 611
LEU A 650
ASN A 657
 None
 0.92A 6f88B-2zxoA:
undetectable		 6f88B-2zxoA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ
(Thermus
thermophilus) 		4 / 4 LYS A 283
LEU A 306
ALA A 281
LEU A 278
 None
 1.50A 6gnrA-2zxoA:
undetectable		 6gnrA-2zxoA:
12.97