SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.13A 1iepA-2zygA:
undetectable		 1iepA-2zygA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ILE A 253
PHE A 239
ILE A 197
ILE A 238
ILE A 232
 None
 1.09A 1r5lA-2zygA:
undetectable		 1r5lA-2zygA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 8 ASP A 376
PHE A 393
ARG A 361
ALA A 390
 None
 1.20A 1rqpA-2zygA:
undetectable		 1rqpA-2zygA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 7 SER A 278
ILE A 189
ILE A 280
THR A 420
 None
 0.98A 1sbrB-2zygA:
undetectable		 1sbrB-2zygA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 7 LEU A 204
THR A 235
LEU A 210
SER A 211
 None
 0.83A 1tyrB-2zygA:
undetectable		 1tyrB-2zygA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ALA A 357
ILE A 356
ILE A 374
ALA A 334
LEU A 277
 None
 1.05A 1uduB-2zygA:
undetectable		 1uduB-2zygA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		3 / 3 PRO A 138
ASN A  21
ARG A  25
 None
 1.09A 2qeuB-2zygA:
undetectable		 2qeuB-2zygA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 6 ILE A  97
ARG A 111
LEU A 115
LEU A  72
 None
 1.01A 2rlfA-2zygA:
undetectable
2rlfD-2zygA:
undetectable		 2rlfA-2zygA:
6.67
2rlfD-2zygA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 8 ASP A 376
PHE A 393
ARG A 361
ALA A 390
 None
 1.19A 2v7uA-2zygA:
undetectable		 2v7uA-2zygA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 4 GLY A 177
GLY A 143
GLY A 174
GLY A 179
 None
 0.60A 3bogC-2zygA:
undetectable		 3bogC-2zygA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 4 GLY A 177
GLY A 143
GLY A 174
GLY A 179
 None
 0.56A 3bogD-2zygA:
undetectable		 3bogD-2zygA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ASN A 187
VAL A 185
GLY A 179
ILE A 123
GLN A 145
 None
 1.49A 3bwmA-2zygA:
6.9		 3bwmA-2zygA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 8 GLY A  26
ILE A  22
VAL A  29
GLN A   5
 None
 0.81A 3fi0I-2zygA:
undetectable		 3fi0I-2zygA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 6 VAL A 152
VAL A   8
ILE A 159
MET A  11
 None
 1.13A 3ms9A-2zygA:
undetectable		 3ms9A-2zygA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 4 ASN A 352
GLY A 354
GLU A 355
LYS A 358
 None
 0.65A 3r2cA-2zygA:
1.2		 3r2cA-2zygA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 10 THR A 218
LEU A 203
VAL A 418
PHE A 421
VAL A 321
 None
 1.49A 3u9fE-2zygA:
undetectable		 3u9fE-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 THR A 218
LEU A 203
PHE A 421
VAL A 321
ALA A 198
 None
 1.37A 3u9fG-2zygA:
undetectable
3u9fH-2zygA:
undetectable		 3u9fG-2zygA:
16.77
3u9fH-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 10 THR A 218
LEU A 203
VAL A 418
PHE A 421
VAL A 321
 None
 1.49A 3u9fI-2zygA:
undetectable		 3u9fI-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 11 THR A 218
LEU A 203
VAL A 418
PHE A 421
VAL A 321
 None
 1.50A 3u9fN-2zygA:
undetectable
3u9fO-2zygA:
undetectable		 3u9fN-2zygA:
16.77
3u9fO-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 9 THR A 218
LEU A 203
VAL A 418
PHE A 421
VAL A 321
 None
 1.45A 3u9fP-2zygA:
undetectable		 3u9fP-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 THR A 218
LEU A 203
VAL A 418
PHE A 421
VAL A 321
 None
 1.43A 3u9fP-2zygA:
undetectable
3u9fS-2zygA:
undetectable		 3u9fP-2zygA:
16.77
3u9fS-2zygA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 LEU A 371
LEU A 387
LEU A 196
TYR A 326
ALA A 424
 None
 1.03A 3vw7A-2zygA:
undetectable		 3vw7A-2zygA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ILE A  22
GLU A  45
GLU A 132
GLU A 131
VAL A   8
 None
 1.01A 4a97B-2zygA:
2.0
4a97C-2zygA:
2.2		 4a97B-2zygA:
21.27
4a97C-2zygA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 THR A 134
PRO A 138
ILE A 123
VAL A 152
ILE A   6
 None
 1.16A 4eb6B-2zygA:
undetectable
4eb6C-2zygA:
3.9		 4eb6B-2zygA:
22.37
4eb6C-2zygA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		3 / 3 ASP A 345
ARG A 341
ASP A 350
 None
 0.85A 4fp9D-2zygA:
3.7		 4fp9D-2zygA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ILE A 359
PHE A 337
LEU A 196
LEU A 279
LEU A 371
 None
 1.35A 4j03A-2zygA:
2.8		 4j03A-2zygA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 6 LEU A 204
THR A 235
LEU A 210
SER A 211
 None
 0.81A 4pwjA-2zygA:
undetectable		 4pwjA-2zygA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 7 LEU A 204
THR A 235
LEU A 210
SER A 211
 None
 0.80A 4pwjB-2zygA:
undetectable		 4pwjB-2zygA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 GLY A 179
ASN A 102
ILE A  98
THR A  80
ILE A  96
 None
 0.96A 4q5mA-2zygA:
undetectable		 4q5mA-2zygA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ASN A 187
VAL A 185
GLY A 179
ILE A 123
GLN A 145
 None
 1.44A 4xucA-2zygA:
6.9		 4xucA-2zygA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		4 / 7 LEU A 204
THR A 235
LEU A 210
SER A 211
 None
 0.79A 5bojB-2zygA:
undetectable		 5bojB-2zygA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 GLY A 129
PHE A 393
TYR A 378
PHE A 370
HIS A 186
 None
 1.16A 5fsaB-2zygA:
undetectable		 5fsaB-2zygA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 PHE A  32
GLY A   7
SER A  63
VAL A  52
LEU A  51
 None
 1.11A 5kocB-2zygA:
4.1		 5kocB-2zygA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 12 ASN A 187
VAL A 185
GLY A 179
ILE A 123
GLN A 145
 None
 1.46A 5lsaA-2zygA:
6.8		 5lsaA-2zygA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING
(Klebsiella
pneumoniae) 		5 / 7 GLY A 101
GLY A 100
GLY A 124
GLY A 177
GLY A 179
 None
 1.05A 6ag0A-2zygA:
undetectable		 6ag0A-2zygA:
11.91