SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 9 ARG A 275
ILE A 456
PRO A 457
ALA A 458
ILE A 466
 None
 1.33A 1aj6A-2zyiA:
undetectable		 1aj6A-2zyiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 6 GLY A 249
GLY A  36
GLN A 469
PHE A 320
 None
 0.95A 2qx6A-2zyiA:
undetectable
2qx6B-2zyiA:
4.9		 2qx6A-2zyiA:
19.75
2qx6B-2zyiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 5 VAL A  25
GLN A  41
PHE A  58
ARG A  44
 None
 1.35A 3bjwE-2zyiA:
undetectable		 3bjwE-2zyiA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 10 ARG A 361
GLY A 356
LEU A 358
VAL A 379
ILE A 442
 None
 1.08A 3em4V-2zyiA:
undetectable		 3em4V-2zyiA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 8 SER A 309
TYR A 313
VAL A 338
LEU A 336
 None
 1.00A 3jq7C-2zyiA:
4.5		 3jq7C-2zyiA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 372
ASN A 207
ASN A 182
ILE A 394
 None
 1.30A 3kp6A-2zyiA:
undetectable
3kp6B-2zyiA:
undetectable		 3kp6A-2zyiA:
15.63
3kp6B-2zyiA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 10 THR A  62
PRO A 425
GLY A  79
GLY A  33
ALA A  32
 None
None
None
STE  A 500 ( 4.0A)
STE  A 500 (-4.7A)
 1.37A 3pp7B-2zyiA:
undetectable		 3pp7B-2zyiA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 4 VAL A 403
VAL A 386
ASN A 382
ILE A 440
 None
 1.28A 4cutA-2zyiA:
undetectable		 4cutA-2zyiA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 115
TRP A  65
SER A 148
 None
 0.84A 4lrhB-2zyiA:
undetectable		 4lrhB-2zyiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 115
TRP A  65
SER A 148
 None
 0.88A 4lrhF-2zyiA:
undetectable		 4lrhF-2zyiA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 115
LEU A 114
PHE A 111
 None
 0.33A 4pthA-2zyiA:
undetectable		 4pthA-2zyiA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 SER A 148
ASP A  61
ASP A 108
 None
 0.77A 4uckA-2zyiA:
undetectable		 4uckA-2zyiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		5 / 12 ARG A 275
ILE A 456
PRO A 457
ALA A 458
ILE A 466
 None
 1.27A 4uroC-2zyiA:
undetectable		 4uroC-2zyiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		4 / 9 ALA A 327
GLU A  39
LEU A 330
ILE A 467
 None
None
STE  A 500 ( 4.4A)
None
 0.91A 4xtaA-2zyiA:
undetectable		 4xtaA-2zyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2zyi LIPASE, PUTATIVE
(Archaeoglobus
fulgidus) 		3 / 3 HIS A 464
HIS A 314
ARG A 275
 None
 1.00A 6b58A-2zyiA:
undetectable		 6b58A-2zyiA:
22.96