SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 106
GLY A 108
GLN A 135
ALA A 255
LEU A 256
 None
 1.18A 1gs4A-2zyjA:
undetectable		 1gs4A-2zyjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 389
LEU A 390
LEU A 386
LEU A 369
ALA A 337
 None
 1.09A 1h9zA-2zyjA:
undetectable		 1h9zA-2zyjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A 317
LEU A 331
ASN A 365
VAL A 316
 None
 1.03A 1lqtA-2zyjA:
undetectable		 1lqtA-2zyjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A 317
LEU A 331
ASN A 365
VAL A 316
 None
 1.02A 1lqtB-2zyjA:
undetectable		 1lqtB-2zyjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A 317
LEU A 331
ASN A 365
VAL A 316
 None
 1.04A 1lquA-2zyjA:
undetectable		 1lquA-2zyjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A 317
LEU A 331
ASN A 365
VAL A 316
 None
 1.02A 1lquB-2zyjA:
undetectable		 1lquB-2zyjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 PHE A 341
LEU A 367
LEU A 369
THR A  29
LEU A  28
 None
 1.11A 1og5A-2zyjA:
undetectable		 1og5A-2zyjA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ASP A 202
PRO A 170
THR A 180
GLY A 178
THR A 176
 PGU  A 500 (-2.8A)
None
None
None
None
 1.49A 2uvnB-2zyjA:
undetectable		 2uvnB-2zyjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 305
PHE A 172
ILE A 169
ASN A 174
ASP A 203
 None
None
PGU  A 500 ( 4.3A)
PGU  A 500 (-3.5A)
None
 1.34A 2zznB-2zyjA:
undetectable		 2zznB-2zyjA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 VAL A 349
GLY A 387
GLY A 392
ALA A 389
GLU A 381
 None
 1.14A 3aruA-2zyjA:
undetectable		 3aruA-2zyjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A 158
VAL A 142
LEU A 188
LEU A 104
 None
 0.89A 3g8iA-2zyjA:
undetectable		 3g8iA-2zyjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A 140
LEU A 119
ARG A 195
 None
 0.76A 3hcnB-2zyjA:
undetectable		 3hcnB-2zyjA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ILE A 379
SER A 370
SER A  36
 None
 0.54A 3iltH-2zyjA:
undetectable		 3iltH-2zyjA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 218
SER A 217
GLU A 201
LEU A 168
ASP A 202
 None
None
None
None
PGU  A 500 (-2.8A)
 1.25A 3ko0A-2zyjA:
undetectable
3ko0B-2zyjA:
undetectable
3ko0C-2zyjA:
undetectable
3ko0D-2zyjA:
undetectable		 3ko0A-2zyjA:
14.80
3ko0B-2zyjA:
14.80
3ko0C-2zyjA:
14.80
3ko0D-2zyjA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A 341
PHE A 351
ALA A  38
LEU A  28
 None
 1.05A 3t3sC-2zyjA:
undetectable		 3t3sC-2zyjA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 PRO A 181
THR A 180
LEU A 188
 None
 0.78A 3ttrA-2zyjA:
undetectable		 3ttrA-2zyjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 5 VAL A 316
ARG A 317
MET A 329
GLU A 330
 None
 1.13A 4hojA-2zyjA:
undetectable		 4hojA-2zyjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 PRO A 321
LEU A 305
VAL A 383
TYR A 371
 None
 0.98A 4pwdA-2zyjA:
undetectable		 4pwdA-2zyjA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ILE A  87
VAL A  83
GLY A 234
THR A  97
VAL A  94
 None
 1.22A 4r20B-2zyjA:
undetectable		 4r20B-2zyjA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 168
LEU A 166
LEU A 188
ALA A 153
LEU A 154
 None
 1.08A 4wg0B-2zyjA:
undetectable
4wg0C-2zyjA:
undetectable
4wg0D-2zyjA:
undetectable		 4wg0B-2zyjA:
3.19
4wg0C-2zyjA:
3.19
4wg0D-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 168
LEU A 166
LEU A 188
ALA A 153
LEU A 154
 None
 1.07A 4wg0D-2zyjA:
undetectable
4wg0E-2zyjA:
undetectable
4wg0F-2zyjA:
undetectable		 4wg0D-2zyjA:
3.19
4wg0E-2zyjA:
3.19
4wg0F-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 168
LEU A 166
LEU A 188
ALA A 153
LEU A 154
 None
 1.09A 4wg0F-2zyjA:
undetectable
4wg0G-2zyjA:
undetectable
4wg0H-2zyjA:
undetectable		 4wg0F-2zyjA:
3.19
4wg0G-2zyjA:
3.19
4wg0H-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 168
LEU A 166
LEU A 188
ALA A 153
LEU A 154
 None
 1.12A 4wg0H-2zyjA:
undetectable
4wg0I-2zyjA:
undetectable
4wg0J-2zyjA:
undetectable		 4wg0H-2zyjA:
3.19
4wg0I-2zyjA:
3.19
4wg0J-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 153
LEU A 154
LEU A 188
LEU A 168
LEU A 166
 None
 1.09A 4wg0G-2zyjA:
undetectable
4wg0H-2zyjA:
undetectable
4wg0I-2zyjA:
undetectable		 4wg0G-2zyjA:
3.19
4wg0H-2zyjA:
3.19
4wg0I-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 168
LEU A 166
LEU A 188
ALA A 153
LEU A 154
 None
 1.08A 4wg0J-2zyjA:
undetectable
4wg0K-2zyjA:
undetectable
4wg0L-2zyjA:
undetectable		 4wg0J-2zyjA:
3.19
4wg0K-2zyjA:
3.19
4wg0L-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 153
LEU A 154
LEU A 188
LEU A 168
LEU A 166
 None
 1.07A 4wg0I-2zyjA:
undetectable
4wg0J-2zyjA:
undetectable
4wg0K-2zyjA:
undetectable		 4wg0I-2zyjA:
3.19
4wg0J-2zyjA:
3.19
4wg0K-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 153
LEU A 154
LEU A 188
LEU A 168
LEU A 166
 None
 1.09A 4wg0K-2zyjA:
undetectable
4wg0L-2zyjA:
undetectable
4wg0M-2zyjA:
undetectable		 4wg0K-2zyjA:
3.19
4wg0L-2zyjA:
3.19
4wg0M-2zyjA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ILE A 129
GLY A 127
ASN A 174
ASP A 202
 None
None
PGU  A 500 (-3.5A)
PGU  A 500 (-2.8A)
 0.93A 5hieD-2zyjA:
undetectable		 5hieD-2zyjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 240
PHE A 236
ARG A 289
PHE A  82
 None
 0.80A 5m0oC-2zyjA:
undetectable		 5m0oC-2zyjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ARG A 206
LEU A 179
PRO A 170
SER A 217
 None
 1.46A 5syjA-2zyjA:
undetectable		 5syjA-2zyjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 5 PHE A  37
PHE A 351
LEU A 386
LEU A  28
 None
 1.24A 5veuH-2zyjA:
undetectable		 5veuH-2zyjA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 10 PRO A 253
HIS A 252
GLY A  75
THR A  73
ALA A 249
 None
 1.31A 5vyhA-2zyjA:
undetectable		 5vyhA-2zyjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ALA A 131
VAL A 200
TYR A 167
 None
 0.64A 5zmqH-2zyjA:
undetectable		 5zmqH-2zyjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 352
PHE A 326
TYR A 205
ILE A 169
ASN A 174
 None
None
PGU  A 500 (-4.5A)
PGU  A 500 ( 4.3A)
PGU  A 500 (-3.5A)
 1.09A 6mxtA-2zyjA:
undetectable		 6mxtA-2zyjA:
22.90