SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 TRP A 308
PHE A 301
SER A 253
VAL A 275
ALA A 230
 None
 1.30A 1nw5A-2zylA:
undetectable		 1nw5A-2zylA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 225
HIS A 207
VAL A 368
LEU A 189
THR A 191
 None
 1.15A 1z9yA-2zylA:
undetectable		 1z9yA-2zylA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 182
TYR A 192
PRO A 190
THR A 357
 FE2  A 452 ( 4.9A)
None
None
None
 1.49A 2q6kA-2zylA:
undetectable		 2q6kA-2zylA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  95
ASP A  96
SER A 116
 None
 0.50A 2qhfA-2zylA:
undetectable		 2qhfA-2zylA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  42
ALA A  45
VAL A  43
GLU A  44
VAL A  52
 None
 1.06A 4da7A-2zylA:
undetectable		 4da7A-2zylA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  42
VAL A  43
GLU A  44
SER A  75
VAL A  52
 None
 1.19A 4danA-2zylA:
undetectable		 4danA-2zylA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  42
VAL A  43
GLU A  44
SER A  75
VAL A  52
 None
 1.24A 4danA-2zylA:
undetectable
4danB-2zylA:
undetectable		 4danA-2zylA:
20.73
4danB-2zylA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 313
TYR A 260
ASN A 257
 None
 0.91A 4ffwB-2zylA:
undetectable		 4ffwB-2zylA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 120
ARG A 122
ASP A  59
 None
 0.76A 4fp9A-2zylA:
undetectable		 4fp9A-2zylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 120
ARG A 122
ASP A  59
 None
 0.80A 4fp9C-2zylA:
undetectable		 4fp9C-2zylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 120
ARG A 122
ASP A  59
 None
 0.79A 4fp9F-2zylA:
undetectable		 4fp9F-2zylA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 257
GLN A 204
ASN A 195
LEU A 329
ILE A 173
 None
 1.27A 4kukA-2zylA:
undetectable		 4kukA-2zylA:
16.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		12 / 12 ASN A 175
VAL A 176
HIS A 186
GLN A 204
LEU A 226
ALA A 230
MET A 238
ASN A 240
LEU A 255
ASN A 257
GLY A 300
ASP A 304
 None
None
FE2  A 452 (-3.3A)
None
None
None
None
None
None
None
None
FE2  A 452 (-2.0A)
 0.25A 4qckA-2zylA:
53.2		 4qckA-2zylA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		7 / 12 ASN A 175
VAL A 176
HIS A 186
GLN A 204
LEU A 242
GLY A 300
ASP A 304
 None
None
FE2  A 452 (-3.3A)
None
None
None
FE2  A 452 (-2.0A)
 1.21A 4qckA-2zylA:
53.2		 4qckA-2zylA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		6 / 12 HIS A 181
ALA A 230
MET A 238
ASN A 240
ASN A 257
ASP A 304
 FE2  A 452 (-3.3A)
None
None
None
None
FE2  A 452 (-2.0A)
 1.30A 4qckA-2zylA:
53.2		 4qckA-2zylA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 181
LEU A 226
SER A 228
ALA A 230
MET A 238
 FE2  A 452 (-3.3A)
None
None
None
None
 0.89A 4qdcA-2zylA:
45.6		 4qdcA-2zylA:
61.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		9 / 12 VAL A 176
HIS A 186
GLN A 204
LEU A 226
SER A 228
ALA A 230
MET A 238
LEU A 255
ASN A 257
 None
FE2  A 452 (-3.3A)
None
None
None
None
None
None
None
 0.82A 4qdcA-2zylA:
45.6		 4qdcA-2zylA:
61.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 311
ILE A 307
ILE A 185
 None
 0.57A 4y0qA-2zylA:
2.1		 4y0qA-2zylA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  69
GLY A  72
GLY A  71
HIS A  89
 FES  A 451 (-3.2A)
FES  A 451 (-4.0A)
FES  A 451 ( 4.6A)
FES  A 451 (-3.1A)
 0.76A 5f8yB-2zylA:
undetectable		 5f8yB-2zylA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2zyl POSSIBLE
OXIDOREDUCTASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 177
MET A 179
HIS A 181
 None
None
FE2  A 452 (-3.3A)
 0.83A 5uunA-2zylA:
undetectable		 5uunA-2zylA:
20.91