SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		3 / 3 TRP A  24
ALA A  27
VAL A  54
 None
 0.91A 1c4dA-2zymA:
undetectable
1c4dB-2zymA:
undetectable		 1c4dA-2zymA:
13.58
1c4dB-2zymA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 11 PHE A 179
ILE A 134
ALA A 132
LEU A 267
ALA A 275
 None
 1.47A 1jb0B-2zymA:
undetectable		 1jb0B-2zymA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 ILE A 252
ILE A 134
ALA A 132
THR A 277
ALA A 344
 None
 1.18A 2j0dA-2zymA:
undetectable		 2j0dA-2zymA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 LEU A  77
ILE A  49
THR A  47
ILE A  97
LEU A 286
 None
 1.16A 2jn3A-2zymA:
undetectable		 2jn3A-2zymA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 5 TRP A 360
GLY A 202
PHE A 278
PHE A 174
 ACX  A 901 (-3.6A)
None
None
None
 0.97A 2qr2A-2zymA:
undetectable
2qr2B-2zymA:
undetectable		 2qr2A-2zymA:
20.34
2qr2B-2zymA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 ILE A 246
PHE A 174
PHE A 278
GLY A 248
 None
 0.93A 3em0B-2zymA:
undetectable		 3em0B-2zymA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 GLY A 339
VAL A 262
ILE A 252
GLY A 248
VAL A 131
 None
 1.05A 3nu5B-2zymA:
undetectable		 3nu5B-2zymA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 11 PHE A 179
ILE A 134
ALA A 132
LEU A 267
ALA A 275
 None
 1.46A 3pcqB-2zymA:
undetectable		 3pcqB-2zymA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 TYR A 147
LEU A 150
PHE A 179
LEU A 180
ALA A 371
 None
 1.17A 3vw7A-2zymA:
undetectable		 3vw7A-2zymA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 4 LEU A  85
TYR A 289
PRO A  96
ILE A  97
 None
 1.20A 5esgA-2zymA:
undetectable		 5esgA-2zymA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 8 PHE A 189
THR A  90
ILE A 353
GLY A  86
 None
 0.88A 5nzxA-2zymA:
undetectable		 5nzxA-2zymA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 PHE A 189
THR A  90
ILE A 353
GLY A  86
 None
 0.92A 5nzyA-2zymA:
undetectable		 5nzyA-2zymA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 10 PHE A 179
ILE A 134
ALA A 132
LEU A 267
ALA A 275
 None
 1.45A 5oy0b-2zymA:
undetectable		 5oy0b-2zymA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 7 GLY A  72
TRP A  24
ASP A  76
TYR A 292
 None
 1.06A 5vlmG-2zymA:
undetectable		 5vlmG-2zymA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 GLY A  41
ALA A  40
VAL A  23
LEU A  77
PRO A  55
 None
 1.01A 6dh0B-2zymA:
undetectable		 6dh0B-2zymA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 GLY A  41
ALA A  40
VAL A  23
LEU A  77
VAL A  53
 None
 0.84A 6dh0B-2zymA:
undetectable		 6dh0B-2zymA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		5 / 12 GLY A  41
ALA A  40
VAL A  23
LEU A  77
PRO A  55
 None
 1.02A 6dh6B-2zymA:
undetectable		 6dh6B-2zymA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2zym SOLUTE-BINDING
PROTEIN
(Thermoactinomyce
s
vulgaris) 		4 / 5 GLN A 152
GLU A 221
ASN A 158
TYR A 147
 None
 1.42A 6iftA-2zymA:
undetectable		 6iftA-2zymA:
23.83