SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		3 / 4 VAL X 135
TRP X 264
TRP X 172
 None
 1.33A 1gmkC-2zyvX:
undetectable
1gmkD-2zyvX:
undetectable		 1gmkC-2zyvX:
4.63
1gmkD-2zyvX:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 12 ILE X 104
ARG X  78
LEU X  58
LEU X 208
ILE X 204
 None
 1.20A 1xzxX-2zyvX:
undetectable		 1xzxX-2zyvX:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
ALA X 146
HIS X 149
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
NPO  X1601 (-4.0A)
 1.48A 2a3rA-2zyvX:
45.5		 2a3rA-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_A_LDPA297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.36A 2a3rA-2zyvX:
45.5		 2a3rA-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
ALA X 146
HIS X 149
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
NPO  X1601 (-4.0A)
 1.46A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3R_B_LDPB297_1
(MONOAMINE-SULFATING
PHENOL
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PRO X  47
PHE X  81
LYS X 106
HIS X 108
HIS X 149
 PPS  X1501 (-4.3A)
NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 (-4.0A)
 0.34A 2a3rB-2zyvX:
45.6		 2a3rB-2zyvX:
57.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
MET X 145
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
None
 0.94A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.02A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
LYS X  48
HIS X 108
PHE X 142
PHE X   8
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.30A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PRO X  47
LYS X  48
HIS X 108
PHE X 142
ALA X 146
PHE X   8
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 1.27A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PRO X  47
LYS X  48
LYS X 106
HIS X 108
ALA X 146
MET X 145
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1601 ( 4.1A)
None
 1.48A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_A_ESTA304_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		7 / 10 PRO X  47
LYS X  48
LYS X 106
HIS X 108
PHE X 142
ALA X 146
MET X 248
 PPS  X1501 (-4.3A)
PPS  X1501 (-2.8A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 0.39A 2d06A-2zyvX:
45.4		 2d06A-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PHE X  21
PRO X  47
HIS X 108
PHE X 142
PHE X   8
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 1.37A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		6 / 10 PHE X  21
PRO X  47
HIS X 108
PHE X 142
TYR X 240
MET X 248
 NPO  X1601 (-4.4A)
PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
None
 1.03A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 10 PRO X  47
HIS X 108
PHE X 142
ALA X 146
PHE X   8
 PPS  X1501 (-4.3A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
 1.32A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		7 / 10 PRO X  47
LYS X 106
HIS X 108
PHE X 142
ALA X 146
TYR X 240
MET X 248
 PPS  X1501 (-4.3A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
NPO  X1601 ( 4.1A)
None
None
 0.42A 2d06B-2zyvX:
45.4		 2d06B-2zyvX:
58.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 5 LEU X  12
ALA X  25
ILE X  24
SER X  23
 None
 1.15A 2othA-2zyvX:
undetectable		 2othA-2zyvX:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 5 TRP X 155
GLY X 153
PRO X 152
PHE X 158
 None
 1.21A 2rezA-2zyvX:
0.0		 2rezA-2zyvX:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 VAL X 135
PHE X 192
VAL X  54
TRP X  53
 None
GOL  X1004 (-3.7A)
None
PPS  X1501 (-3.3A)
 1.48A 2y00A-2zyvX:
0.0		 2y00A-2zyvX:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 5 VAL X 135
VAL X 136
GLN X 144
PHE X 169
 None
 1.05A 3bjwB-2zyvX:
undetectable		 3bjwB-2zyvX:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 12 LEU X 211
LEU X 208
ILE X  41
ILE X  43
LEU X 189
 None
 1.23A 4j24B-2zyvX:
undetectable		 4j24B-2zyvX:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 9 PHE X  81
LYS X 106
HIS X 108
ILE X  89
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
NPO  X1602 (-4.2A)
 1.27A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.32A 4jvlA-2zyvX:
44.9		 4jvlA-2zyvX:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JVL_B_ESTB302_1
(ESTROGEN
SULFOTRANSFERASE)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 PHE X  81
LYS X 106
HIS X 108
PHE X 142
MET X 248
 NPO  X1601 ( 4.5A)
NPO  X1601 ( 2.8A)
NPO  X1601 ( 3.7A)
PPS  X1501 ( 4.1A)
None
 0.35A 4jvlB-2zyvX:
44.6		 4jvlB-2zyvX:
56.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 12 GLY X 170
LEU X  12
LEU X  20
TYR X 139
TYR X 143
 None
 1.15A 4lg1B-2zyvX:
undetectable		 4lg1B-2zyvX:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		3 / 3 LEU X 113
MET X  82
TYR X  46
 None
 0.89A 4p6xG-2zyvX:
undetectable		 4p6xG-2zyvX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 7 ILE X 104
ARG X  78
VAL X  79
ILE X  75
GLU X  56
 None
 1.34A 4zzbC-2zyvX:
undetectable
4zzbD-2zyvX:
undetectable		 4zzbC-2zyvX:
21.55
4zzbD-2zyvX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		3 / 3 ILE X  86
PRO X  87
ILE X  89
 None
None
NPO  X1602 (-4.2A)
 0.42A 5hw8F-2zyvX:
undetectable		 5hw8F-2zyvX:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		3 / 3 TYR X 280
TYR X 127
SER X  49
 None
 1.00A 5iktB-2zyvX:
undetectable		 5iktB-2zyvX:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 GLU X 217
PRO X 216
ILE X 215
LEU X 220
 None
GOL  X1001 ( 4.9A)
None
None
 1.32A 5m45A-2zyvX:
undetectable		 5m45A-2zyvX:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		4 / 4 GLU X 217
PRO X 216
ILE X 215
LEU X 220
 None
GOL  X1001 ( 4.9A)
None
None
 1.34A 5m45D-2zyvX:
undetectable		 5m45D-2zyvX:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 9 LEU X 189
VAL X 128
ILE X 204
LEU X 211
MET X 196
 None
 1.33A 5og9A-2zyvX:
undetectable		 5og9A-2zyvX:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2zyv TYROSINE-ESTER
SULFOTRANSFERASE
(Mus
musculus) 		5 / 12 ILE X  24
VAL X  31
ILE X 148
HIS X 108
MET X  95
 None
None
NPO  X1601 (-4.0A)
NPO  X1601 ( 3.7A)
None
 1.45A 6j21A-2zyvX:
undetectable		 6j21A-2zyvX:
19.28