SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 10 LEU A  63
VAL A 118
ILE A 165
GLY A  75
PHE A 195
 None
 0.92A 1d4sA-2zz8A:
undetectable		 1d4sA-2zz8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 10 LEU A  63
VAL A 118
ILE A 165
GLY A  75
ILE A 193
 None
 0.88A 1hsgA-2zz8A:
undetectable		 1hsgA-2zz8A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		4 / 8 GLY A  75
SER A 210
ILE A 116
ASP A 148
 None
 0.91A 1jg4A-2zz8A:
undetectable		 1jg4A-2zz8A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 12 SER A 194
TYR A 151
ALA A  60
GLY A  52
PRO A 137
 None
 1.23A 1vpoH-2zz8A:
undetectable
1vpoL-2zz8A:
2.2		 1vpoH-2zz8A:
22.48
1vpoL-2zz8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 12 LEU A  63
VAL A 118
ILE A 165
GLY A  75
ILE A 193
 None
 0.88A 2o4lB-2zz8A:
undetectable		 2o4lB-2zz8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 12 PRO A  81
ALA A 209
PHE A 195
GLY A  42
TYR A  41
 None
 1.02A 2zifB-2zz8A:
undetectable		 2zifB-2zz8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 9 LEU A  63
VAL A 118
ILE A 165
GLY A  75
ILE A 193
 None
 0.90A 3ekqB-2zz8A:
undetectable		 3ekqB-2zz8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		5 / 11 LEU A  63
VAL A 118
ILE A 165
GLY A  75
ILE A 193
 None
 0.95A 4qgiB-2zz8A:
undetectable		 4qgiB-2zz8A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zz8 LIPL32 PROTEIN
(Leptospira
interrogans) 		4 / 8 ILE A  71
PRO A 224
ILE A 165
THR A 163
 None
 1.04A 6cduG-2zz8A:
undetectable
6cduH-2zz8A:
undetectable		 6cduG-2zz8A:
20.78
6cduH-2zz8A:
20.78