SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 THR A 736
GLU A 744
HIS A 630
LEU A 623
 None
 1.29A 1d4fC-2zzgA:
undetectable		 1d4fC-2zzgA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A 721
HIS A 617
VAL A 714
TYR A 689
LEU A 693
 ZN  A 901 ( 4.7A)
ZN  A 901 (-3.4A)
None
None
None
 1.37A 1dmyA-2zzgA:
undetectable		 1dmyA-2zzgA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 722
PRO A 723
LEU A 727
 None
 0.47A 1hrkA-2zzgA:
undetectable		 1hrkA-2zzgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 719
GLY A 554
GLN A 555
GLY A 696
GLY A 697
 None
 1.05A 1mxgA-2zzgA:
undetectable		 1mxgA-2zzgA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 TYR A 273
LEU A 398
VAL A 391
ILE A 390
ILE A 338
 None
 1.42A 1q6iB-2zzgA:
undetectable		 1q6iB-2zzgA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 TYR A 251
PHE A  66
HIS A  78
LEU A 169
 None
 1.16A 1x8vA-2zzgA:
undetectable		 1x8vA-2zzgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 617
HIS A 721
HIS A 613
 ZN  A 901 (-3.4A)
ZN  A 901 ( 4.7A)
ZN  A 901 (-3.5A)
 0.74A 2dysN-2zzgA:
undetectable		 2dysN-2zzgA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 617
HIS A 721
HIS A 613
 ZN  A 901 (-3.4A)
ZN  A 901 ( 4.7A)
ZN  A 901 (-3.5A)
 0.72A 2einA-2zzgA:
2.6		 2einA-2zzgA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 704
ALA A 716
VAL A 699
LEU A 645
MET A 620
 None
 1.07A 2g78A-2zzgA:
undetectable		 2g78A-2zzgA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A 300
THR A 138
GLY A 139
HIS A 141
PHE A 145
 None
None
None
A5A  A 999 (-4.8A)
A5A  A 999 (-3.4A)
 1.46A 2hmaA-2zzgA:
undetectable		 2hmaA-2zzgA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ILE A 746
ILE A 661
VAL A 626
LEU A 627
VAL A 631
 None
 0.90A 2kawA-2zzgA:
undetectable		 2kawA-2zzgA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 TRP A 258
TYR A 339
TYR A  45
ILE A  48
 None
 0.77A 2ph9A-2zzgA:
undetectable
2ph9B-2zzgA:
undetectable		 2ph9A-2zzgA:
15.12
2ph9B-2zzgA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 722
PRO A 723
LEU A 727
 None
 0.56A 2po5B-2zzgA:
undetectable		 2po5B-2zzgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 722
PRO A 723
LEU A 727
 None
 0.49A 2po7B-2zzgA:
undetectable		 2po7B-2zzgA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A 153
PRO A 115
THR A 683
TRP A 107
 None
 1.45A 2q6kA-2zzgA:
2.0		 2q6kA-2zzgA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 722
PRO A 723
LEU A 727
 None
 0.35A 2qd5B-2zzgA:
undetectable		 2qd5B-2zzgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLN A 105
ARG A 128
GLY A 195
GLY A 250
 None
A5A  A 999 (-3.0A)
None
A5A  A 999 (-3.5A)
 0.63A 2y6rB-2zzgA:
undetectable		 2y6rB-2zzgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 THR A 249
PHE A 216
LEU A 169
HIS A  78
PRO A 119
 None
 1.20A 2y7kD-2zzgA:
undetectable		 2y7kD-2zzgA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 GLN A 575
THR A 720
HIS A 613
LEU A 638
 None
None
ZN  A 901 (-3.5A)
None
 1.22A 2zj0A-2zzgA:
undetectable		 2zj0A-2zzgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 VAL A 247
HIS A  78
THR A 166
LEU A 169
 None
 1.08A 3arrA-2zzgA:
undetectable		 3arrA-2zzgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 GLN A 575
THR A 720
HIS A 613
LEU A 638
 None
None
ZN  A 901 (-3.5A)
None
 1.26A 3ce6C-2zzgA:
undetectable		 3ce6C-2zzgA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 551
HIS A 613
HIS A 609
 None
ZN  A 901 (-3.5A)
None
 0.91A 3co4A-2zzgA:
undetectable		 3co4A-2zzgA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 744
SER A 359
VAL A 361
 None
 0.81A 3eeoA-2zzgA:
undetectable		 3eeoA-2zzgA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ARG A 625
GLY A 696
GLY A 621
MET A 620
LEU A 645
 None
 0.95A 3ku1C-2zzgA:
undetectable		 3ku1C-2zzgA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 347
LEU A 366
LEU A 370
GLY A 364
ILE A 127
 None
 1.46A 3lbdA-2zzgA:
undetectable		 3lbdA-2zzgA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 HIS A 613
HIS A 617
ARG A 705
HIS A 721
 ZN  A 901 (-3.5A)
ZN  A 901 (-3.4A)
None
ZN  A 901 ( 4.7A)
 0.86A 3nvcA-2zzgA:
undetectable		 3nvcA-2zzgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 411
GLU A 414
GLU A 657
TYR A 650
VAL A 631
 None
 1.36A 3rlbB-2zzgA:
1.9		 3rlbB-2zzgA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 HIS A 617
HIS A 721
HIS A 613
 ZN  A 901 (-3.4A)
ZN  A 901 ( 4.7A)
ZN  A 901 (-3.5A)
 0.80A 3s3bA-2zzgA:
undetectable		 3s3bA-2zzgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 645
PHE A 748
LEU A 638
GLY A 696
GLN A 633
 None
 1.20A 3tbgA-2zzgA:
1.8		 3tbgA-2zzgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 645
PHE A 748
LEU A 638
GLY A 696
GLN A 633
 None
 1.19A 3tbgC-2zzgA:
1.7		 3tbgC-2zzgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 310
LEU A 313
ASN A 295
ILE A 332
 None
 0.94A 3u5jA-2zzgA:
undetectable		 3u5jA-2zzgA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 214
VAL A 167
VAL A 204
PHE A  70
HIS A 150
 None
 1.42A 3u9fH-2zzgA:
undetectable
3u9fI-2zzgA:
undetectable		 3u9fH-2zzgA:
14.25
3u9fI-2zzgA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 LEU A 214
VAL A 167
VAL A 204
PHE A  70
HIS A 150
 None
 1.47A 3u9fN-2zzgA:
undetectable
3u9fO-2zzgA:
undetectable		 3u9fN-2zzgA:
14.25
3u9fO-2zzgA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A 599
ILE A 563
VAL A 585
VAL A 541
 None
 0.84A 3ufnB-2zzgA:
undetectable		 3ufnB-2zzgA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A 127
ILE A 144
ALA A 353
ILE A 412
HIS A 394
 None
 0.93A 3uvvA-2zzgA:
undetectable		 3uvvA-2zzgA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLN A 105
ARG A 128
GLY A 195
GLY A 250
 None
A5A  A 999 (-3.0A)
None
A5A  A 999 (-3.5A)
 0.49A 3v3nB-2zzgA:
undetectable		 3v3nB-2zzgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLN A 105
ARG A 128
GLY A 195
GLY A 250
 None
A5A  A 999 (-3.0A)
None
A5A  A 999 (-3.5A)
 0.49A 3v3nC-2zzgA:
undetectable		 3v3nC-2zzgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 PRO A  40
ASP A  43
GLU A  44
 None
 0.83A 3v4tC-2zzgA:
undetectable		 3v4tC-2zzgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 722
PRO A 723
LEU A 727
 None
 0.37A 3w1wB-2zzgA:
undetectable		 3w1wB-2zzgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 129
VAL A 356
SER A 359
 None
 0.92A 4acbB-2zzgA:
5.0
4acbC-2zzgA:
4.3		 4acbB-2zzgA:
22.29
4acbC-2zzgA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 LEU A 214
TYR A 161
HIS A 151
HIS A 150
 None
 1.22A 4arcA-2zzgA:
2.4		 4arcA-2zzgA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 TYR A  84
GLN A 124
ASP A 354
GLU A 407
 None
 1.47A 4azvA-2zzgA:
undetectable		 4azvA-2zzgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 THR A 464
HIS A 377
HIS A 344
TYR A 458
 None
 1.35A 4df2A-2zzgA:
undetectable		 4df2A-2zzgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 7 ALA A 212
PHE A 174
ALA A 170
THR A 249
 None
 0.93A 4du2A-2zzgA:
undetectable		 4du2A-2zzgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 195
GLY A 196
TYR A 239
VAL A  97
ILE A 101
 None
 1.20A 4fglA-2zzgA:
undetectable
4fglB-2zzgA:
undetectable		 4fglA-2zzgA:
14.93
4fglB-2zzgA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A 721
ILE A 709
TRP A 712
ASP A 672
GLY A 726
 ZN  A 901 ( 4.7A)
None
None
None
None
 1.04A 4fogA-2zzgA:
undetectable		 4fogA-2zzgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 HIS A 721
ILE A 709
TRP A 712
ASP A 672
GLY A 726
 ZN  A 901 ( 4.7A)
None
None
None
None
 1.05A 4fogC-2zzgA:
undetectable		 4fogC-2zzgA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ASN A 295
ALA A 299
SER A 296
TYR A 339
 None
 0.97A 4ijiF-2zzgA:
undetectable		 4ijiF-2zzgA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 128
PHE A 145
THR A 213
ARG A 255
 A5A  A 999 (-3.0A)
A5A  A 999 (-3.4A)
A5A  A 999 (-3.1A)
A5A  A 999 (-3.7A)
 0.57A 4k87A-2zzgA:
8.3		 4k87A-2zzgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 VAL A 167
ALA A 170
PHE A 202
ASP A 164
THR A   7
 None
 1.23A 4mm8A-2zzgA:
undetectable		 4mm8A-2zzgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 665
ILE A 731
GLY A 615
GLY A 726
ILE A 709
 None
 0.95A 4q5mA-2zzgA:
undetectable		 4q5mA-2zzgA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ASP A 103
VAL A  94
ASP A  93
GLY A 195
 None
 0.98A 4xp6A-2zzgA:
undetectable		 4xp6A-2zzgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 606
ASP A 558
TYR A 520
 None
 0.93A 4yo9B-2zzgA:
undetectable		 4yo9B-2zzgA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A  75
ARG A   8
TYR A  76
GLU A 165
 None
 1.50A 4zzbD-2zzgA:
2.6		 4zzbD-2zzgA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 VAL A 675
LEU A 619
ARG A 625
ILE A 661
 None
 0.80A 5jw1A-2zzgA:
undetectable		 5jw1A-2zzgA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 GLN A 608
ALA A 643
GLN A 637
HIS A 609
 None
 1.04A 5km8A-2zzgA:
undetectable
5km8B-2zzgA:
undetectable		 5km8A-2zzgA:
11.98
5km8B-2zzgA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 373
HIS A 344
HIS A 377
 None
 0.91A 5oexA-2zzgA:
undetectable		 5oexA-2zzgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 373
HIS A 344
HIS A 377
 None
 0.91A 5oexB-2zzgA:
undetectable		 5oexB-2zzgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 373
HIS A 344
HIS A 377
 None
 0.92A 5oexC-2zzgA:
undetectable		 5oexC-2zzgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LYS A 373
HIS A 344
HIS A 377
 None
 0.91A 5oexD-2zzgA:
undetectable		 5oexD-2zzgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 10 ARG A 128
HIS A 141
PHE A 145
GLU A 210
GLY A 252
ARG A 255
 A5A  A 999 (-3.0A)
A5A  A 999 (-4.8A)
A5A  A 999 (-3.4A)
A5A  A 999 (-3.4A)
A5A  A 999 (-3.2A)
A5A  A 999 (-3.7A)
 0.77A 6bniA-2zzgA:
10.8		 6bniA-2zzgA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 10 ARG A 128
HIS A 141
PHE A 145
GLU A 210
GLY A 252
ARG A 255
 A5A  A 999 (-3.0A)
A5A  A 999 (-4.8A)
A5A  A 999 (-3.4A)
A5A  A 999 (-3.4A)
A5A  A 999 (-3.2A)
A5A  A 999 (-3.7A)
 0.75A 6bniB-2zzgA:
10.8		 6bniB-2zzgA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2zzg ALANYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 VAL A 743
ALA A 634
GLN A 740
 None
 0.59A 6gb9A-2zzgA:
undetectable		 6gb9A-2zzgA:
21.00