SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zzj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		4 / 6 SER A  28
THR A  35
LEU A  38
ASP A 222
 None
None
None
CA  A 239 (-2.2A)
 1.38A 1mxdA-2zzjA:
undetectable		 1mxdA-2zzjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		4 / 5 LEU A  76
MET A  40
LEU A 199
GLN A 214
 None
 1.08A 1p93D-2zzjA:
undetectable		 1p93D-2zzjA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		4 / 7 ILE A 114
ARG A  75
PHE A  74
PHE A 172
 None
CIT  A 240 (-2.8A)
None
None
 0.90A 2qb4A-2zzjA:
undetectable		 2qb4A-2zzjA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		3 / 3 TYR A  15
ARG A 196
HIS A  53
 None
 1.13A 4fubA-2zzjA:
undetectable		 4fubA-2zzjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		4 / 8 TYR A 128
ARG A 135
ASP A 206
ARG A 122
 None
 1.24A 4kr4C-2zzjA:
undetectable		 4kr4C-2zzjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		5 / 12 ILE A 112
TYR A 221
VAL A 197
ALA A  37
VAL A 224
 None
 1.10A 5igjA-2zzjA:
undetectable		 5igjA-2zzjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		4 / 6 ARG A  60
PHE A 193
PHE A 195
ILE A 158
 None
 1.17A 5vceA-2zzjA:
undetectable		 5vceA-2zzjA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2zzj GLUCURONAN LYASE A
(Trichoderma
reesei) 		3 / 3 ARG A 122
PHE A 172
LEU A 156
 None
 0.79A 5veuA-2zzjA:
undetectable		 5veuA-2zzjA:
18.43