SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 8 GLY A 298
GLY A 300
TYR A 290
TRP A 291
HIS A 367
 SO4  A 402 (-3.5A)
SO4  A 402 (-3.3A)
SO4  A 402 (-4.5A)
None
None
 1.33A 1dbbH-2zzrA:
undetectable
1dbbL-2zzrA:
undetectable		 1dbbH-2zzrA:
20.10
1dbbL-2zzrA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 6 TRP A 251
GLY A 255
ASN A 179
PRO A 257
 None
 1.40A 1dedA-2zzrA:
undetectable		 1dedA-2zzrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 7 GLY A 371
ALA A  55
TYR A 364
GLU A  68
 None
 0.88A 1dmaA-2zzrA:
undetectable		 1dmaA-2zzrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 5 LYS A 146
GLU A 149
ALA A 143
LEU A 119
 None
 1.05A 1eta1-2zzrA:
undetectable		 1eta1-2zzrA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 5 LYS A 146
GLU A 149
ALA A 143
LEU A 119
 None
 1.08A 1eta2-2zzrA:
undetectable		 1eta2-2zzrA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 6 LYS A 146
GLU A 149
ALA A 143
LEU A 119
 None
 1.09A 1etb1-2zzrA:
undetectable		 1etb1-2zzrA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 10 ASP A 380
GLY A 379
ILE A 377
TYR A  61
GLY A 375
 None
 1.45A 1fohA-2zzrA:
undetectable		 1fohA-2zzrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 10 ASP A 380
GLY A 379
ILE A 377
TYR A  61
GLY A 375
 None
 1.50A 1fohB-2zzrA:
undetectable		 1fohB-2zzrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 9 ASN A  97
LEU A  78
ALA A  81
LEU A  40
LEU A 384
 None
 1.40A 1hwiA-2zzrA:
undetectable		 1hwiA-2zzrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 7 LEU A 177
TYR A 204
LEU A 271
GLN A 268
 None
 1.10A 1kt3A-2zzrA:
undetectable		 1kt3A-2zzrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 8 LYS A   5
HIS A 202
SER A 206
VAL A 210
 SO4  A 401 ( 4.3A)
None
None
None
 1.35A 1u1jA-2zzrA:
undetectable		 1u1jA-2zzrA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 12 TYR A 347
ALA A 307
ALA A 250
SER A 289
PHE A 279
 None
 1.07A 1ve3B-2zzrA:
undetectable		 1ve3B-2zzrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 12 ALA A 246
GLN A 249
LEU A 293
ILE A 294
ALA A 217
 None
 0.95A 2aclG-2zzrA:
undetectable		 2aclG-2zzrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 6 LYS A 146
GLU A 149
ALA A 143
LEU A 119
 None
 1.01A 2roxB-2zzrA:
undetectable		 2roxB-2zzrA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 PRO A 357
GLY A 375
TYR A  61
 None
 0.73A 2vouA-2zzrA:
undetectable		 2vouA-2zzrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 PRO A 357
GLY A 375
TYR A  61
 None
 0.72A 2vouB-2zzrA:
undetectable		 2vouB-2zzrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 PRO A 357
GLY A 375
TYR A  61
 None
 0.71A 2vouC-2zzrA:
undetectable		 2vouC-2zzrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 6 TYR A 290
VAL A 288
TYR A 347
ASP A 297
 SO4  A 402 (-4.5A)
None
None
None
 1.47A 2x45A-2zzrA:
undetectable		 2x45A-2zzrA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 283
TRP A 245
TYR A 278
 None
 0.98A 3aicA-2zzrA:
undetectable		 3aicA-2zzrA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 283
TRP A 245
TYR A 278
 None
 0.99A 3aicB-2zzrA:
undetectable		 3aicB-2zzrA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 283
TRP A 245
TYR A 278
 None
 0.99A 3aicE-2zzrA:
undetectable		 3aicE-2zzrA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 283
TRP A 245
TYR A 278
 None
 0.98A 3aicF-2zzrA:
undetectable		 3aicF-2zzrA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 283
TRP A 245
TYR A 278
 None
 0.99A 3aicH-2zzrA:
undetectable		 3aicH-2zzrA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 5 THR A 235
SER A 244
SER A 216
ARG A 212
 None
None
None
SO4  A 401 (-3.7A)
 1.18A 3hlwB-2zzrA:
undetectable		 3hlwB-2zzrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 TYR A 151
LEU A 119
ARG A 150
 None
 0.58A 3sufB-2zzrA:
undetectable		 3sufB-2zzrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 8 ALA A 143
PHE A 185
ALA A 186
THR A 190
 None
 0.84A 3t3sD-2zzrA:
undetectable		 3t3sD-2zzrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 8 ALA A 143
PHE A 185
ALA A 186
THR A 190
 None
 0.82A 3t3sE-2zzrA:
undetectable		 3t3sE-2zzrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 8 ALA A 143
PHE A 185
ALA A 186
THR A 190
 None
 0.86A 3t3sF-2zzrA:
undetectable		 3t3sF-2zzrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 LEU A 340
HIS A 337
MET A 336
 None
 0.88A 3thrD-2zzrA:
undetectable		 3thrD-2zzrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 6 GLY A 252
ILE A 174
LYS A   5
LEU A 271
 None
None
SO4  A 401 ( 4.3A)
None
 1.07A 4acaC-2zzrA:
undetectable		 4acaC-2zzrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 6 GLY A 252
ILE A 174
LYS A   5
LEU A 271
 None
None
SO4  A 401 ( 4.3A)
None
 1.05A 4acbC-2zzrA:
undetectable		 4acbC-2zzrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 PHE A 118
TYR A 254
TYR A 382
 None
 1.07A 4ffwA-2zzrA:
undetectable		 4ffwA-2zzrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 12 ASP A 145
GLU A 149
LEU A 183
LEU A 182
GLY A 117
 None
 1.33A 4pgfB-2zzrA:
undetectable		 4pgfB-2zzrA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 8 GLY A  72
SER A 123
PHE A 101
SER A 100
 None
 1.02A 4ws1A-2zzrA:
undetectable		 4ws1A-2zzrA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 7 ALA A  55
GLY A 375
SER A 306
GLY A 379
 None
 0.88A 5e26A-2zzrA:
undetectable
5e26B-2zzrA:
undetectable		 5e26A-2zzrA:
21.88
5e26B-2zzrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 8 ALA A  55
GLY A 375
SER A 306
GLY A 379
 None
 0.90A 5e26C-2zzrA:
undetectable
5e26D-2zzrA:
undetectable		 5e26C-2zzrA:
21.88
5e26D-2zzrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		5 / 11 LEU A  80
ASP A 380
LEU A 359
GLY A 379
ALA A  36
 None
 1.39A 5fctA-2zzrA:
undetectable		 5fctA-2zzrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 4 CYH A  77
LEU A 358
LEU A  40
ALA A  36
 None
 0.98A 5hpuA-2zzrA:
undetectable
5hpuB-2zzrA:
undetectable		 5hpuA-2zzrA:
4.60
5hpuB-2zzrA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 5 PRO A 257
LEU A 340
TYR A 381
PHE A  73
 None
 1.22A 5igjA-2zzrA:
undetectable		 5igjA-2zzrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		4 / 5 PRO A 257
LEU A 343
TYR A 381
PHE A  73
 None
 1.26A 5igjA-2zzrA:
undetectable		 5igjA-2zzrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 VAL A 363
SER A 365
TRP A 366
 None
 0.99A 5jwaA-2zzrA:
undetectable		 5jwaA-2zzrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2zzr UNSATURATED
GLUCURONYL HYDROLASE
(Streptococcus
agalactiae) 		3 / 3 ILE A 377
ASN A  97
CYH A 124
 None
 0.89A 6bp4A-2zzrA:
undetectable		 6bp4A-2zzrA:
18.89