SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 PHE A 188
ILE A 160
PHE A 172
GLY A 238
 None
 0.91A 2qwxA-2zzwA:
undetectable
2qwxB-2zzwA:
undetectable		 2qwxA-2zzwA:
19.45
2qwxB-2zzwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 VAL A  47
ASN A 291
TRP A 295
 None
 1.12A 2y00B-2zzwA:
undetectable		 2y00B-2zzwA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 ILE A 287
PHE A  98
PRO A 220
PHE A 228
 None
LAC  A 401 (-4.0A)
None
None
 1.09A 2ygnA-2zzwA:
undetectable		 2ygnA-2zzwA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 151
ASP A 136
TYR A 149
ARG A 140
 None
 1.06A 3arrA-2zzwA:
undetectable		 3arrA-2zzwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 151
ASP A 136
TYR A 149
ARG A 140
 None
 1.05A 3aruA-2zzwA:
undetectable		 3aruA-2zzwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 10 MET A 330
ALA A 337
GLU A 336
LEU A 112
ARG A 140
 None
 1.37A 3erdB-2zzwA:
undetectable		 3erdB-2zzwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A  48
MET A 252
PHE A 217
ASN A  96
 None
None
LAC  A 401 ( 4.6A)
None
 1.30A 3uq6B-2zzwA:
undetectable		 3uq6B-2zzwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 THR A  40
VAL A  69
PRO A  71
TYR A  49
 None
 1.05A 4grkA-2zzwA:
3.2		 4grkA-2zzwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 ASP A 312
ILE A 160
ILE A 245
PHE A 172
PRO A 220
 None
 1.17A 4nnrA-2zzwA:
undetectable
4nnrB-2zzwA:
undetectable		 4nnrA-2zzwA:
18.78
4nnrB-2zzwA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 PHE A 188
ILE A 160
PHE A 172
GLY A 238
 None
 0.91A 4qogA-2zzwA:
undetectable
4qogB-2zzwA:
undetectable		 4qogA-2zzwA:
19.45
4qogB-2zzwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 MET A 106
ASP A 253
PHE A  98
 None
None
LAC  A 401 (-4.0A)
 0.97A 4xeyA-2zzwA:
undetectable		 4xeyA-2zzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 MET A 106
ASP A 253
PHE A  98
 None
None
LAC  A 401 (-4.0A)
 0.99A 4xeyB-2zzwA:
undetectable		 4xeyB-2zzwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 PHE A  81
GLY A 181
TYR A 101
ARG A 178
 None
None
LAC  A 401 (-4.4A)
LAC  A 401 (-2.9A)
 1.15A 4yshB-2zzwA:
undetectable		 4yshB-2zzwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A  33
LYS A  60
GLU A  68
 None
 0.76A 5d0yA-2zzwA:
undetectable		 5d0yA-2zzwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 TRP A 295
GLY A 219
PRO A 220
ASP A 156
 None
 0.79A 5kf8A-2zzwA:
undetectable		 5kf8A-2zzwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 TRP A 295
GLY A 219
PRO A 220
ASP A 156
 None
 0.76A 5kgpA-2zzwA:
undetectable		 5kgpA-2zzwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 TRP A 295
GLY A 219
PRO A 220
ASP A 156
 None
 0.73A 5kgpB-2zzwA:
undetectable		 5kgpB-2zzwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 GLU A 304
VAL A 303
LEU A 177
ALA A 232
GLN A 247
 None
None
None
None
ZN  A 362 ( 2.7A)
 1.31A 5syeB-2zzwA:
undetectable		 5syeB-2zzwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A 159
LEU A 226
ASN A 223
PHE A 217
PHE A  98
 None
None
None
LAC  A 401 ( 4.6A)
LAC  A 401 (-4.0A)
 1.42A 6dwnB-2zzwA:
undetectable		 6dwnB-2zzwA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 11 PHE A 188
THR A 195
GLY A 181
ILE A 184
ILE A 160
 None
 0.94A 6ebzC-2zzwA:
undetectable		 6ebzC-2zzwA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 11 PHE A 188
THR A 195
GLY A 181
ILE A 184
ILE A 160
 None
 0.92A 6ebzD-2zzwA:
undetectable		 6ebzD-2zzwA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  67
THR A  63
GLY A  65
ARG A  33
 None
 1.28A 6gtqB-2zzwA:
undetectable
6gtqD-2zzwA:
undetectable		 6gtqB-2zzwA:
18.01
6gtqD-2zzwA:
8.36