SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 8 PHE C 301
TYR C 186
VAL C  99
GLY C 102
 None
 0.90A 1ekjE-3a0hC:
undetectable
1ekjF-3a0hC:
undetectable		 1ekjE-3a0hC:
20.58
1ekjF-3a0hC:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 8 PHE B 250
SER D 155
ILE D 159
LEU B 460
LEU D 291
 CLA  B1010 ( 3.7A)
CLA  D1004 ( 4.7A)
DGD  B1058 (-4.5A)
DGD  B1058 (-3.6A)
DGD  B1058 ( 4.6A)
 1.24A 1eupA-3a0hB:
undetectable		 1eupA-3a0hB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3a0h PHOTOSYSTEM II
REACTION CENTER
PROTEIN I
(Thermosynechococ
cus
vulcanus) 		4 / 4 THR I  13
LEU I  17
VAL I  20
LEU I  24
 None
 0.76A 1fbmD-3a0hI:
undetectable		 1fbmD-3a0hI:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3a0h PHOTOSYSTEM II
REACTION CENTER
PROTEIN I
(Thermosynechococ
cus
vulcanus) 		4 / 5 THR I  13
LEU I  17
VAL I  20
LEU I  24
 None
 0.71A 1fbmE-3a0hI:
2.3		 1fbmE-3a0hI:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 GLY D  34
LEU D  37
GLY D  31
ARG D 128
 None
 1.33A 1j7kA-3a0hD:
undetectable		 1j7kA-3a0hD:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 HIS B 216
ALA B 212
PHE B 144
GLY B 140
 None
 1.22A 1mj2B-3a0hB:
undetectable		 1mj2B-3a0hB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 HIS B 216
ALA B 212
PHE B 144
GLY B 140
 None
 1.25A 1mj2D-3a0hB:
undetectable		 1mj2D-3a0hB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 HIS B 216
ALA B 212
PHE B 144
GLY B 140
 None
 1.23A 1mjoB-3a0hB:
undetectable		 1mjoB-3a0hB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 HIS B 216
ALA B 212
PHE B 144
GLY B 140
 None
 1.24A 1mjoA-3a0hB:
undetectable		 1mjoA-3a0hB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 HIS B 216
ALA B 212
PHE B 144
GLY B 140
 None
 1.23A 1mjoD-3a0hB:
undetectable		 1mjoD-3a0hB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 5 GLU B 283
ARG B 358
LEU B 309
ASP B 313
 None
 1.21A 1n13B-3a0hB:
undetectable
1n13C-3a0hB:
undetectable		 1n13B-3a0hB:
12.50
1n13C-3a0hB:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 ARG B 286
ASP B 313
ASN B 318
 None
 0.95A 1nbhD-3a0hB:
undetectable		 1nbhD-3a0hB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.18A 1q23A-3a0hB:
undetectable		 1q23A-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.10A 1q23F-3a0hB:
undetectable		 1q23F-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.12A 1q23K-3a0hB:
undetectable		 1q23K-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.37A 1v8bA-3a0hB:
undetectable		 1v8bA-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.42A 1v8bB-3a0hB:
undetectable		 1v8bB-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.38A 1v8bD-3a0hB:
undetectable		 1v8bD-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD6_0
(GRAMICIDIN D)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 TRP D  48
TRP D 111
ALA D 177
VAL D  78
 PHO  D1039 ( 3.5A)
None
None
None
 1.50A 1w5uC-3a0hD:
undetectable
1w5uD-3a0hD:
undetectable		 1w5uC-3a0hD:
4.00
1w5uD-3a0hD:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 9 GLN B 281
GLY B 427
ALA B 344
VAL B 345
PHE B 355
 None
 1.38A 2drdA-3a0hB:
undetectable		 2drdA-3a0hB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 7 ARG D 326
LYS B 321
ASN B 318
ALA B 320
 None
 1.28A 2ejgA-3a0hD:
undetectable		 2ejgA-3a0hD:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC6_0
(GRAMICIDIN D)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA D 177
VAL D  78
TRP D  48
TRP D 111
 None
None
PHO  D1039 ( 3.5A)
None
 1.48A 2izqC-3a0hD:
undetectable
2izqD-3a0hD:
undetectable		 2izqC-3a0hD:
4.00
2izqD-3a0hD:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 ASP B  15
ASN B  14
THR B 128
 None
 0.59A 2pymB-3a0hB:
undetectable		 2pymB-3a0hB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 ASP B  15
ASN B  14
THR B 128
 None
 0.71A 2q63B-3a0hB:
undetectable		 2q63B-3a0hB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 5 PHE B 363
PHE D 168
SER D 172
PHE D 339
 None
 1.12A 2v0mD-3a0hB:
undetectable		 2v0mD-3a0hB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 ARG C 390
GLU C 300
ASP C 187
 None
 0.85A 3g2oA-3a0hC:
undetectable		 3g2oA-3a0hC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 PHE B 311
ASP B 334
TYR B 314
PRO B  54
 None
 1.37A 3jqaB-3a0hB:
undetectable		 3jqaB-3a0hB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 ARG C 362
SER C 226
ASP C 232
TYR C 212
 None
DGD  C1055 (-3.1A)
None
None
 1.30A 3jqaC-3a0hC:
undetectable		 3jqaC-3a0hC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 ARG C 362
SER C 226
ASP C 232
TYR C 212
 None
DGD  C1055 (-3.1A)
None
None
 1.28A 3jqaD-3a0hC:
undetectable		 3jqaD-3a0hC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 PHE B  61
VAL B 252
THR B 263
PHE B  65
 CLA  B1015 ( 3.4A)
CLA  B1012 (-4.5A)
None
CLA  B1012 ( 3.2A)
 1.39A 3ltwA-3a0hB:
undetectable		 3ltwA-3a0hB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 4 VAL D 287
PHE B 453
PHE B 451
VAL B 252
 DGD  B1058 (-4.2A)
None
CLA  B1012 (-3.6A)
CLA  B1012 (-4.5A)
 1.41A 3rv5C-3a0hD:
1.5
3rv5D-3a0hD:
undetectable		 3rv5C-3a0hD:
13.82
3rv5D-3a0hD:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 PHE B 464
TYR D 141
ARG D 128
LEU D 122
 MGE  B1060 ( 3.9A)
None
None
PHO  D1039 (-4.7A)
 1.31A 3sueA-3a0hB:
0.0		 3sueA-3a0hB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 10 ASP B 380
VAL B 368
ILE B 381
ALA B 424
VAL B 356
 None
 0.99A 3t3cB-3a0hB:
undetectable		 3t3cB-3a0hB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 8 HIS B 469
TRP B 468
PHE B 479
PRO B   4
 CLA  B1019 (-3.8A)
CLA  B1019 ( 3.4A)
None
None
 1.29A 3v35A-3a0hB:
undetectable		 3v35A-3a0hB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 GLY B 196
VAL B 181
PRO B 183
GLY B 154
 None
 0.83A 4dxuA-3a0hB:
undetectable		 4dxuA-3a0hB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 7 GLY B 196
VAL B 181
PRO B 183
GLY B 154
 None
 0.82A 4forA-3a0hB:
undetectable		 4forA-3a0hB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.05A 4fqsA-3a0hD:
undetectable		 4fqsA-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.07A 4fqsB-3a0hD:
undetectable		 4fqsB-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 TYR B 402
ARG B 347
SER B 400
 None
 0.99A 4khpI-3a0hB:
undetectable
4khpJ-3a0hB:
undetectable		 4khpI-3a0hB:
13.52
4khpJ-3a0hB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 GLY C 235
PHE C 181
ILE C 199
ALA C 179
HIS C 237
 None
None
None
None
CLA  C1025 (-3.7A)
 1.42A 4wh5A-3a0hC:
undetectable		 4wh5A-3a0hC:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 VAL C  99
TYR C 186
ALA C  93
 None
 0.56A 4ybnA-3a0hC:
undetectable		 4ybnA-3a0hC:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CAD_A_ACTA402_0
(SM80.1 VICILIN)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 PHE B 432
ALA B 337
ASN B 317
ARG B  57
 None
 1.43A 5cadA-3a0hB:
0.0		 5cadA-3a0hB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 5 VAL D  28
GLY D  31
ARG D 128
PHE D  38
 None
 0.85A 5d4nA-3a0hD:
undetectable
5d4nC-3a0hD:
undetectable		 5d4nA-3a0hD:
13.20
5d4nC-3a0hD:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 4 VAL C 466
ALA D 249
ILE C 459
THR D 221
 None
PQ9  D1042 (-3.2A)
None
None
 1.07A 5e4dB-3a0hC:
undetectable		 5e4dB-3a0hC:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 VAL B  96
LEU B 158
MET B 166
 CLA  B1013 (-4.9A)
None
None
 0.90A 5ikrA-3a0hB:
undetectable		 5ikrA-3a0hB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 HIS D 197
VAL D 286
TYR D 160
HIS D 189
 CLA  D1004 ( 4.3A)
CLA  D1004 (-4.1A)
IOD  D1068 (-3.7A)
None
 1.35A 5kkzA-3a0hD:
undetectable
5kkzG-3a0hD:
undetectable		 5kkzA-3a0hD:
23.06
5kkzG-3a0hD:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 7 HIS D 189
HIS D 197
VAL D 286
TYR D 160
 None
CLA  D1004 ( 4.3A)
CLA  D1004 (-4.1A)
IOD  D1068 (-3.7A)
 1.32A 5kkzM-3a0hD:
undetectable
5kkzO-3a0hD:
undetectable		 5kkzM-3a0hD:
19.76
5kkzO-3a0hD:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.41A 5m66A-3a0hB:
undetectable		 5m66A-3a0hB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.38A 5utuF-3a0hB:
undetectable		 5utuF-3a0hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 7 PHE D 341
VAL D 345
PRO D 347
SER B 365
 None
 1.01A 5vkqA-3a0hD:
2.8
5vkqD-3a0hD:
2.8		 5vkqA-3a0hD:
11.22
5vkqD-3a0hD:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 7 SER B 365
PHE D 341
VAL D 345
PRO D 347
 None
 1.02A 5vkqA-3a0hB:
4.1
5vkqB-3a0hB:
4.1		 5vkqA-3a0hB:
15.42
5vkqB-3a0hB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 8 SER B 365
PHE D 341
VAL D 345
PRO D 347
 None
 1.00A 5vkqB-3a0hB:
4.1
5vkqC-3a0hB:
4.1		 5vkqB-3a0hB:
15.42
5vkqC-3a0hB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 7 SER B 365
PHE D 341
VAL D 345
PRO D 347
 None
 1.00A 5vkqC-3a0hB:
4.1
5vkqD-3a0hB:
4.1		 5vkqC-3a0hB:
15.42
5vkqD-3a0hB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 8 GLY B 173
ILE B 265
TRP B 167
ASP B 170
 None
 1.01A 5vlmH-3a0hB:
undetectable		 5vlmH-3a0hB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 10 MET B 166
GLY B 160
ILE B 203
ALA B 155
PHE B 247
 None
None
None
None
CLA  B1010 ( 3.6A)
 1.42A 5zjiA-3a0hB:
3.0
5zjiJ-3a0hB:
undetectable		 5zjiA-3a0hB:
9.03
5zjiJ-3a0hB:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 8 TRP B 167
ARG B  68
PRO B  64
ILE B  80
 None
 0.91A 6a4iA-3a0hB:
undetectable		 6a4iA-3a0hB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 7 GLY C  96
GLY C 100
PRO C 101
GLY C 102
GLY C 103
 None
 0.96A 6ag0A-3a0hC:
undetectable		 6ag0A-3a0hC:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		5 / 12 ILE C 459
LEU C 467
VAL D 247
PHE D 223
THR D 217
 None
None
None
None
PQ9  D1042 (-2.8A)
 1.08A 6b54A-3a0hC:
undetectable		 6b54A-3a0hC:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 ALA D 290
GLY D 285
ILE D 284
VAL D 154
ILE D 159
 DGD  B1058 ( 4.4A)
None
None
DGD  B1058 (-4.7A)
DGD  B1058 (-4.5A)
 1.16A 6difA-3a0hD:
undetectable		 6difA-3a0hD:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 5 ASN C 294
TYR C 297
ARG C 423
PHE C 289
 None
None
None
CLA  C1025 ( 4.3A)
 1.45A 6h3dA-3a0hC:
undetectable		 6h3dA-3a0hC:
19.96