SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a0u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 3a0u RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 8 ALA A  74
ILE A  77
VAL A  63
ILE A  67
 PG4  A 205 (-4.1A)
None
None
None
 0.46A 1d4yB-3a0uA:
undetectable		 1d4yB-3a0uA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3a0u RESPONSE REGULATOR
(Thermotoga
maritima) 		5 / 12 SER A  91
ALA A  64
GLY A  60
LEU A  61
VAL A  99
 None
 1.31A 1vpoH-3a0uA:
undetectable
1vpoL-3a0uA:
undetectable		 1vpoH-3a0uA:
15.67
1vpoL-3a0uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3a0u RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 6 ASP A 105
GLU A  24
TYR A  26
LYS A 108
 None
 1.19A 1yc2A-3a0uA:
4.6
1yc2B-3a0uA:
4.6
1yc2E-3a0uA:
4.4		 1yc2A-3a0uA:
19.07
1yc2B-3a0uA:
19.07
1yc2E-3a0uA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3a0u RESPONSE REGULATOR
(Thermotoga
maritima) 		3 / 3 LYS A  40
ARG A  14
VAL A   7
 None
 0.95A 2r2vC-3a0uA:
undetectable
2r2vD-3a0uA:
undetectable		 2r2vC-3a0uA:
16.38
2r2vD-3a0uA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3a0u RESPONSE REGULATOR
(Thermotoga
maritima) 		3 / 3 LYS A  40
LEU A   5
ALA A  37
 None
 0.82A 4iizA-3a0uA:
undetectable		 4iizA-3a0uA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3a0u RESPONSE REGULATOR
(Thermotoga
maritima) 		4 / 4 VAL A  63
GLU A  62
GLY A  34
LEU A  38
 None
 1.15A 5g5gC-3a0uA:
undetectable		 5g5gC-3a0uA:
9.50