SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a14'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 11 ALA A 364
THR A 337
ILE A 334
GLY A 329
ALA A 201
 None
 0.94A 1b02A-3a14A:
undetectable		 1b02A-3a14A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 7 GLU A  78
SER A  35
VAL A  93
ALA A 104
 None
None
NDP  A3001 (-4.1A)
None
 1.08A 1fo4B-3a14A:
undetectable		 1fo4B-3a14A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 8 LEU A 216
VAL A 127
GLY A 124
LEU A 138
 None
 0.96A 1jlbA-3a14A:
undetectable		 1jlbA-3a14A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 7 MET A 254
PRO A 140
ALA A 261
ALA A 115
 NDP  A3001 ( 4.2A)
None
None
NDP  A3001 (-3.9A)
 1.03A 1k5qA-3a14A:
undetectable
1k5qB-3a14A:
undetectable		 1k5qA-3a14A:
19.59
1k5qB-3a14A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 9 LEU A   9
VAL A  91
LEU A 131
LEU A 138
LEU A 120
 None
 0.83A 1xkkA-3a14A:
undetectable		 1xkkA-3a14A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 11 VAL A  22
ILE A 258
LEU A 262
LEU A  31
LEU A   6
 None
None
None
NDP  A3003 (-4.4A)
None
 1.13A 2a15A-3a14A:
undetectable		 2a15A-3a14A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 6 ARG A 332
GLY A 329
PRO A 291
THR A 202
 None
 1.29A 2m2oB-3a14A:
undetectable		 2m2oB-3a14A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 8 ILE A  15
GLY A  16
LEU A  20
LEU A  23
 NDP  A3001 (-4.3A)
None
None
NDP  A3003 ( 4.1A)
 0.89A 2vctB-3a14A:
undetectable		 2vctB-3a14A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		3 / 3 MET A 214
VAL A 151
GLU A 144
 None
 0.84A 2x9gA-3a14A:
8.9		 2x9gA-3a14A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A  84
GLY A  16
ILE A  29
VAL A  52
ILE A  34
 None
 0.79A 3adxB-3a14A:
undetectable		 3adxB-3a14A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 SER A  35
ALA A  56
ILE A  77
LEU A  81
ILE A  32
 None
 0.89A 3adxB-3a14A:
undetectable		 3adxB-3a14A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 SER A  35
ALA A  56
ILE A  77
LEU A  81
LEU A  84
 None
 0.98A 3adxB-3a14A:
undetectable		 3adxB-3a14A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 PHE A 327
ILE A 330
PHE A 309
LEU A 161
ASP A 142
 None
None
None
None
MG  A 900 ( 2.6A)
 1.27A 3aocC-3a14A:
undetectable		 3aocC-3a14A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 LEU A 106
PRO A 347
GLY A 123
LEU A  99
LEU A 138
 None
 1.17A 3e23A-3a14A:
3.7		 3e23A-3a14A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 VAL A  26
LEU A 270
ILE A   8
VAL A 268
ILE A 256
 None
 0.94A 3frqB-3a14A:
undetectable		 3frqB-3a14A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 8 PHE A 208
PHE A 309
GLY A  95
PHE A 293
 None
 1.11A 3ko0B-3a14A:
undetectable
3ko0J-3a14A:
undetectable		 3ko0B-3a14A:
14.79
3ko0J-3a14A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 7 PHE A 208
PHE A 309
GLY A  95
PHE A 293
 None
 1.12A 3ko0K-3a14A:
undetectable
3ko0S-3a14A:
undetectable		 3ko0K-3a14A:
14.79
3ko0S-3a14A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 7 THR A 307
LEU A 103
ASN A 116
LEU A 114
 None
None
NDP  A3001 (-4.0A)
None
 1.07A 4ib4A-3a14A:
undetectable		 4ib4A-3a14A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 PRO A 140
ASN A 116
ALA A 101
GLY A  98
LEU A  99
 None
NDP  A3001 (-4.0A)
None
None
None
 1.49A 4oadA-3a14A:
undetectable		 4oadA-3a14A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 12 ALA A 115
GLY A  16
GLN A  18
ALA A 194
GLU A 118
 NDP  A3001 (-3.9A)
None
None
None
NDP  A3001 (-3.7A)
 1.09A 4r29D-3a14A:
undetectable		 4r29D-3a14A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 9 LEU A 262
ILE A   8
LEU A  20
VAL A  22
THR A  19
 None
 1.17A 4x3mB-3a14A:
2.8		 4x3mB-3a14A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 9 SER A  35
ALA A  56
LEU A  81
LEU A  84
 None
 0.89A 4xtaA-3a14A:
undetectable		 4xtaA-3a14A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 11 SER A  35
ALA A  56
ILE A  77
LEU A  81
ILE A  32
 None
 0.93A 4xumB-3a14A:
undetectable		 4xumB-3a14A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		5 / 11 SER A  35
ALA A  56
ILE A  77
LEU A  81
LEU A  84
 None
 0.97A 4xumB-3a14A:
undetectable		 4xumB-3a14A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 7 LYS A 289
TYR A 290
GLY A 166
LEU A 168
 None
None
MPD  A 800 ( 4.8A)
None
 1.12A 5bphB-3a14A:
5.7		 5bphB-3a14A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 6 LEU A 138
LYS A 117
GLU A 212
LEU A 216
 None
NDP  A3001 (-3.6A)
None
None
 1.29A 5xooA-3a14A:
undetectable		 5xooA-3a14A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 6 LEU A 120
LYS A 128
LEU A 131
LEU A 138
 None
 0.97A 5yvnA-3a14A:
undetectable		 5yvnA-3a14A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Thermotoga
maritima) 		4 / 6 VAL A 353
LEU A  99
LEU A 103
LEU A 120
 None
 0.89A 6f6sA-3a14A:
undetectable
6f6sB-3a14A:
undetectable		 6f6sA-3a14A:
11.48
6f6sB-3a14A:
12.07