SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		5 / 12 ILE C  65
LEU C  93
ALA C  40
ILE C  84
ILE C 134
 None
 1.02A 1epbB-3a1jC:
undetectable		 1epbB-3a1jC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		6 / 12 ILE C  84
ALA C  40
ALA C  63
LEU C  31
ILE C  65
PHE C  82
 None
 1.39A 2h77A-3a1jC:
undetectable		 2h77A-3a1jC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		6 / 12 ILE C  84
ALA C  40
ALA C  63
LEU C  31
ILE C  65
PHE C  82
 None
 1.45A 2h79A-3a1jC:
undetectable		 2h79A-3a1jC:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		5 / 12 ILE C 134
ALA C  63
ILE C  65
LEU C  27
MET C 110
 None
 1.28A 3adsB-3a1jC:
undetectable		 3adsB-3a1jC:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_A_WPPA300_2
(BETA-LACTAMASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 5 CYH C 215
TYR C 203
PRO C 186
THR C 218
 None
 1.31A 3q07A-3a1jC:
undetectable		 3q07A-3a1jC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 5 CYH C 215
TYR C 203
PRO C 186
THR C 218
 None
 1.31A 3q07B-3a1jC:
undetectable		 3q07B-3a1jC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		5 / 12 SER C 231
LEU C 235
ILE C 179
ILE C 243
VAL C 241
 None
 1.10A 3w67D-3a1jC:
undetectable		 3w67D-3a1jC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		5 / 12 ILE C  30
THR C  29
VAL C 241
GLU C 211
ARG C 258
 None
 1.36A 4i41A-3a1jC:
undetectable		 4i41A-3a1jC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 5 ASN C  26
LEU C  21
SER C  28
LEU C 123
 None
 1.20A 4n09C-3a1jC:
undetectable		 4n09C-3a1jC:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 6 SER C 191
LEU C 190
TYR C 223
LEU C 177
 None
 0.92A 4wozA-3a1jC:
undetectable
4wozB-3a1jC:
undetectable		 4wozA-3a1jC:
22.22
4wozB-3a1jC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		5 / 12 LEU C  90
LEU C  27
ALA C  63
VAL C  51
ILE C  34
 None
 1.16A 4x1kD-3a1jC:
undetectable		 4x1kD-3a1jC:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		5 / 11 LEU C  90
LEU C  27
ALA C  63
VAL C  51
ILE C  34
 None
 1.15A 4x20D-3a1jC:
undetectable		 4x20D-3a1jC:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		3 / 3 ARG C 248
ASP C 246
TYR C 270
 None
 0.89A 4yo9B-3a1jC:
undetectable		 4yo9B-3a1jC:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 4 ASN C  26
LEU C  21
SER C  28
LEU C 123
 None
 1.20A 5kb5A-3a1jC:
undetectable		 5kb5A-3a1jC:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 4 THR C 218
VAL C 220
PRO C 186
THR C 180
 None
 1.25A 5mthA-3a1jC:
0.6
5mthH-3a1jC:
0.6		 5mthA-3a1jC:
20.48
5mthH-3a1jC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1
(Homo
sapiens) 		4 / 7 ILE C  84
LEU C 119
MET C 110
LEU C 121
 None
 1.01A 5u4sA-3a1jC:
undetectable		 5u4sA-3a1jC:
17.20