SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a1t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.13A 1ddsA-3a1tA:
undetectable		 1ddsA-3a1tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.12A 1dyiA-3a1tA:
undetectable		 1dyiA-3a1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.04A 1jolA-3a1tA:
undetectable		 1jolA-3a1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 10 VAL A 101
ASP A  69
LEU A  67
LEU A  32
ILE A 125
 None
 1.19A 1sq5D-3a1tA:
undetectable		 1sq5D-3a1tA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 10 LEU A  90
ALA A  22
LEU A  21
PRO A  71
ILE A  68
 None
 1.05A 1yi4A-3a1tA:
undetectable		 1yi4A-3a1tA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		4 / 7 LEU A  76
LEU A  67
VAL A  98
LYS A  54
 None
 0.89A 3g8iA-3a1tA:
1.3		 3g8iA-3a1tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.05A 3ql0A-3a1tA:
undetectable		 3ql0A-3a1tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.15A 4ej1B-3a1tA:
2.3		 4ej1B-3a1tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A 152
VAL A 154
LEU A 150
ALA A 102
LEU A 100
 None
 1.10A 4o1zB-3a1tA:
undetectable		 4o1zB-3a1tA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.11A 4qi9A-3a1tA:
2.4		 4qi9A-3a1tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.14A 4qi9B-3a1tA:
2.4		 4qi9B-3a1tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.09A 4qleA-3a1tA:
undetectable		 4qleA-3a1tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 11 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.09A 4qleB-3a1tA:
2.1		 4qleB-3a1tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 11 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.07A 4qlfA-3a1tA:
undetectable		 4qlfA-3a1tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.11A 4qlgA-3a1tA:
undetectable		 4qlgA-3a1tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.13A 4qlgB-3a1tA:
undetectable		 4qlgB-3a1tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.12A 4x5fA-3a1tA:
2.2		 4x5fA-3a1tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.11A 4x5gA-3a1tA:
2.2		 4x5gA-3a1tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.10A 4x5hA-3a1tA:
2.1		 4x5hA-3a1tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.03A 5e8qB-3a1tA:
undetectable		 5e8qB-3a1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.05A 5eajB-3a1tA:
undetectable		 5eajB-3a1tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.11A 5hi6A-3a1tA:
2.2		 5hi6A-3a1tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.04A 5hi6B-3a1tA:
2.2		 5hi6B-3a1tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		4 / 5 PHE A 156
ILE A 141
MET A 128
ARG A 143
 None
 1.12A 5jm4A-3a1tA:
undetectable		 5jm4A-3a1tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		3 / 3 MET A 120
GLU A  83
ARG A  87
 None
 1.07A 5tjyA-3a1tA:
7.4		 5tjyA-3a1tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1t IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.03A 5ujxB-3a1tA:
undetectable		 5ujxB-3a1tA:
21.05