SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 11 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.05A 1dhiB-3a1wA:
2.0		 1dhiB-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.07A 1draB-3a1wA:
2.0		 1draB-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 10 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.04A 1rb3A-3a1wA:
2.2		 1rb3A-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		6 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
ILE A 172
THR A  37
 None
 1.19A 1rb3B-3a1wA:
2.0		 1rb3B-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.07A 3drcB-3a1wA:
2.3		 3drcB-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 11 LEU A  76
LEU A  70
ALA A  86
ALA A  95
VAL A  98
 None
 1.31A 3e22B-3a1wA:
3.9		 3e22B-3a1wA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
LEU A  97
THR A  37
 None
 1.11A 3ql0A-3a1wA:
undetectable		 3ql0A-3a1wA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.10A 3ql3A-3a1wA:
2.3		 3ql3A-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A 141
LEU A 146
THR A 157
VAL A 154
VAL A 155
 None
 0.93A 3rukB-3a1wA:
undetectable		 3rukB-3a1wA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.08A 4dfrB-3a1wA:
2.0		 4dfrB-3a1wA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		3 / 3 GLU A  83
ASP A  82
ASP A  88
 None
 0.80A 4gc9A-3a1wA:
undetectable		 4gc9A-3a1wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A 152
VAL A 154
LEU A 150
ALA A 102
LEU A 100
 None
 1.02A 4o1zB-3a1wA:
undetectable		 4o1zB-3a1wA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.08A 4ptjA-3a1wA:
undetectable		 4ptjA-3a1wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 LEU A  21
ILE A 125
GLY A 164
VAL A 101
ILE A  99
 None
 0.98A 4q1yB-3a1wA:
undetectable		 4q1yB-3a1wA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 12 ILE A  65
LEU A  21
ILE A 125
ILE A 172
THR A  37
 None
 1.04A 5e8qA-3a1wA:
2.4		 5e8qA-3a1wA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		4 / 5 PHE A 156
ILE A 141
MET A 128
ARG A 143
 None
 1.12A 5jm4A-3a1wA:
undetectable		 5jm4A-3a1wA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 10 SER A  80
ALA A  86
LEU A  76
GLY A  77
LEU A 146
 None
 1.22A 5oy01-3a1wA:
undetectable
5oy07-3a1wA:
undetectable		 5oy01-3a1wA:
20.38
5oy07-3a1wA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 11 ILE A  65
LEU A  21
LEU A  97
ILE A 172
THR A  37
 None
 1.03A 5z6mA-3a1wA:
undetectable		 5z6mA-3a1wA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3a1w IRON(II) TRANSPORT
PROTEIN B
(Thermotoga
maritima) 		5 / 10 SER A  80
ALA A  86
LEU A  76
GLY A  77
LEU A 146
 None
 1.21A 6hqbA-3a1wA:
undetectable
6hqbJ-3a1wA:
undetectable		 6hqbA-3a1wA:
17.68
6hqbJ-3a1wA:
14.08