SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 7 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.90A 1mt1H-3a1yG:
undetectable
1mt1K-3a1yG:
undetectable		 1mt1H-3a1yG:
17.44
1mt1K-3a1yG:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 6 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.92A 1n13H-3a1yG:
undetectable
1n13K-3a1yG:
undetectable		 1n13H-3a1yG:
17.44
1n13K-3a1yG:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 7 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.93A 1n13G-3a1yG:
undetectable
1n13J-3a1yG:
undetectable		 1n13G-3a1yG:
11.74
1n13J-3a1yG:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		5 / 12 ALA G 246
ILE G 243
VAL G 229
ALA G 228
PHE G 225
 None
 1.01A 1uduB-3a1yG:
undetectable		 1uduB-3a1yG:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 7 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.90A 2qqcD-3a1yG:
undetectable
2qqcE-3a1yG:
undetectable		 2qqcD-3a1yG:
18.51
2qqcE-3a1yG:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 8 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.91A 2qqcH-3a1yG:
undetectable
2qqcK-3a1yG:
undetectable		 2qqcH-3a1yG:
18.51
2qqcK-3a1yG:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 8 LEU G 192
ASP G 190
LEU G 189
GLY G 188
 None
 0.93A 2qqdB-3a1yG:
undetectable
2qqdC-3a1yG:
undetectable		 2qqdB-3a1yG:
18.15
2qqdC-3a1yG:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3a1y 50S RIBOSOMAL
PROTEIN P1 (L12P)
(Pyrococcus
horikoshii) 		4 / 7 ASN A  21
GLU A  16
GLU A  19
GLU A  20
 None
 1.13A 4mj8C-3a1yA:
undetectable		 4mj8C-3a1yA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		3 / 3 SER G  32
ASP G 190
GLN G 104
 None
 0.87A 4oltA-3a1yG:
undetectable
4oltB-3a1yG:
undetectable		 4oltA-3a1yG:
23.08
4oltB-3a1yG:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		3 / 3 GLN G 104
SER G  32
ASP G 190
 None
 0.90A 4qwpA-3a1yG:
undetectable
4qwpB-3a1yG:
undetectable		 4qwpA-3a1yG:
23.08
4qwpB-3a1yG:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3a1y ACIDIC RIBOSOMAL
PROTEIN P0
(Pyrococcus
horikoshii) 		4 / 4 LEU G 189
GLY G 188
SER G  32
SER G  31
 None
 1.31A 5uunB-3a1yG:
undetectable		 5uunB-3a1yG:
20.90