SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 VAL A 423
VAL A 369
TRP A 401
 None
 0.75A 1bdwA-3a21A:
undetectable
1bdwB-3a21A:
undetectable		 1bdwA-3a21A:
2.51
1bdwB-3a21A:
2.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 8 LEU A 388
ARG A 384
THR A 382
LEU A 371
ALA A 348
 None
GOL  A 915 ( 4.6A)
GOL  A 917 (-4.1A)
None
GOL  A 915 (-3.4A)
 1.44A 1fiqC-3a21A:
undetectable		 1fiqC-3a21A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 11 LEU A 400
ALA A 334
LYS A 359
ALA A 368
THR A 426
 None
 1.26A 1ictA-3a21A:
undetectable
1ictC-3a21A:
undetectable		 1ictA-3a21A:
13.13
1ictC-3a21A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 ASP A 171
PHE A 175
GLY A 163
ASP A 142
 None
 0.90A 1rmtC-3a21A:
undetectable		 1rmtC-3a21A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 ALA A 462
THR A  48
PHE A 487
 None
 0.73A 2c6nB-3a21A:
undetectable		 2c6nB-3a21A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 5 ARG A 384
THR A 382
LEU A 371
ALA A 348
 GOL  A 915 ( 4.6A)
GOL  A 917 (-4.1A)
None
GOL  A 915 (-3.4A)
 1.17A 2e1qD-3a21A:
undetectable		 2e1qD-3a21A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 GLY A 149
GLY A 161
GLY A 147
 None
 0.39A 3bogC-3a21A:
undetectable		 3bogC-3a21A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 511
LEU A 475
ASN A 457
PRO A 528
VAL A 501
 None
 1.19A 3dcjA-3a21A:
undetectable
3dcjB-3a21A:
undetectable		 3dcjA-3a21A:
18.21
3dcjB-3a21A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 5 ASN A 531
ALA A 356
GLY A 582
THR A 271
 None
None
None
GOL  A 914 (-3.9A)
 0.77A 3dl9A-3a21A:
undetectable		 3dl9A-3a21A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 GLN A 653
ILE A 614
VAL A 657
VAL A 535
 GOL  A 903 ( 4.5A)
None
None
None
 0.75A 3fi0Q-3a21A:
undetectable		 3fi0Q-3a21A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 HIS A 379
LEU A 354
GLY A 420
GLY A 421
ALA A 377
 None
GOL  A 915 (-4.1A)
None
None
None
 1.10A 3i5uA-3a21A:
undetectable		 3i5uA-3a21A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 HIS A 379
LEU A 354
GLY A 420
GLY A 421
ALA A 377
 None
GOL  A 915 (-4.1A)
None
None
None
 1.15A 3i5uB-3a21A:
2.4		 3i5uB-3a21A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 6 VAL A 332
SER A 422
LEU A 388
ILE A 381
 None
None
None
GOL  A 915 (-4.7A)
 0.92A 3kk6A-3a21A:
undetectable		 3kk6A-3a21A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 10 LEU A 388
ALA A 395
GLY A 407
VAL A 406
VAL A 383
 None
 1.00A 3oxwA-3a21A:
undetectable		 3oxwA-3a21A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 10 LEU A 388
ALA A 395
GLY A 407
VAL A 406
VAL A 383
 None
 1.00A 3oxwC-3a21A:
undetectable		 3oxwC-3a21A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 9 LEU A 629
ALA A 588
GLY A 554
ILE A 601
LEU A 642
 None
 1.11A 3u7sA-3a21A:
undetectable		 3u7sA-3a21A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 THR A 271
LEU A 456
GLY A 455
VAL A 477
 GOL  A 914 (-3.9A)
None
None
None
 0.69A 4c9nA-3a21A:
undetectable		 4c9nA-3a21A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 7 GLU A 558
ASP A 545
ASN A 567
ILE A 601
 None
GOL  A 901 (-2.8A)
GOL  A 901 (-3.3A)
None
 0.82A 4ii8A-3a21A:
undetectable		 4ii8A-3a21A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 ARG A 297
TRP A 401
ILE A 326
 SO4  A 978 ( 3.8A)
None
SO4  A 978 (-4.7A)
 0.86A 4mwxA-3a21A:
undetectable		 4mwxA-3a21A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 ASP A 186
TYR A 140
TRP A 226
 None
None
GOL  A 919 (-3.3A)
 1.02A 4p7nA-3a21A:
12.1		 4p7nA-3a21A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 7 TYR A 357
ILE A 381
GLY A 421
LEU A 261
 None
GOL  A 915 (-4.7A)
None
None
 0.87A 4ze3A-3a21A:
undetectable		 4ze3A-3a21A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 ILE A  51
TYR A 463
VAL A  53
HIS A 274
 None
 0.71A 5ecnD-3a21A:
1.4		 5ecnD-3a21A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 TYR A 357
ILE A 381
GLY A 421
LEU A 261
 None
GOL  A 915 (-4.7A)
None
None
 0.89A 5eseA-3a21A:
undetectable		 5eseA-3a21A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 TYR A 357
ILE A 381
GLY A 421
LEU A 261
 None
GOL  A 915 (-4.7A)
None
None
 0.86A 5esfA-3a21A:
undetectable		 5esfA-3a21A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 TYR A 357
ILE A 381
GLY A 421
LEU A 261
 None
GOL  A 915 (-4.7A)
None
None
 0.90A 5esjA-3a21A:
undetectable		 5esjA-3a21A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 198
THR A 552
GLN A 266
GLY A 227
SER A 245
 None
 1.13A 5hfjB-3a21A:
undetectable		 5hfjB-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ASP A 196
ALA A 198
GLN A 266
GLY A 227
SER A 245
 None
 0.83A 5hfjF-3a21A:
undetectable		 5hfjF-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ASP A 196
ALA A 198
THR A 552
GLY A 227
SER A 245
 None
 1.12A 5hfjF-3a21A:
undetectable		 5hfjF-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ASP A 196
ALA A 198
THR A 552
GLY A 227
TYR A 228
 None
 1.29A 5hfjF-3a21A:
undetectable		 5hfjF-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ASP A 196
ALA A 198
THR A 552
GLN A 266
GLY A 227
 None
 1.34A 5hfjH-3a21A:
undetectable		 5hfjH-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ASP A 196
THR A 552
GLN A 266
GLY A 227
TYR A 228
 None
 1.40A 5hfjH-3a21A:
undetectable		 5hfjH-3a21A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 5 TYR A 357
LYS A 346
GLU A 349
GLY A 353
 None
GOL  A 911 (-3.5A)
GOL  A 911 ( 3.0A)
None
 1.20A 5jhdJ-3a21A:
undetectable		 5jhdJ-3a21A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 7 ILE A 139
ILE A  97
THR A 127
ILE A 130
 None
 0.71A 5murB-3a21A:
undetectable		 5murB-3a21A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ILE A 130
ILE A 333
ALA A  90
LEU A  87
ALA A  85
 None
 1.11A 5oy02-3a21A:
undetectable		 5oy02-3a21A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 VAL A 623
GLY A 592
LEU A 644
THR A 594
 None
 1.00A 5sxqA-3a21A:
undetectable		 5sxqA-3a21A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 VAL A 623
GLY A 592
LEU A 644
THR A 594
 None
 1.00A 5sxtA-3a21A:
undetectable		 5sxtA-3a21A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 8 VAL A 623
GLY A 592
LEU A 644
THR A 594
 None
 0.99A 5syjB-3a21A:
undetectable		 5syjB-3a21A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		3 / 3 TRP A 303
MET A 300
ASN A 296
 None
 1.48A 5uc1A-3a21A:
undetectable		 5uc1A-3a21A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 THR A 571
VAL A 579
VAL A 347
ARG A 575
SER A 386
 None
None
None
GOL  A 911 (-3.9A)
None
 1.39A 5v1tA-3a21A:
4.2		 5v1tA-3a21A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 SER A  62
GLY A 163
ILE A  70
THR A 154
GLY A 147
 None
None
None
1PG  A 964 ( 3.9A)
None
 1.05A 5veuH-3a21A:
undetectable		 5veuH-3a21A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 7 GLY A 189
GLY A 144
GLY A 163
GLY A 104
GLY A 161
 None
 0.89A 6ag0A-3a21A:
11.9		 6ag0A-3a21A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 449
LEU A 342
VAL A 360
THR A 530
GLY A 455
 None
 1.46A 6brdA-3a21A:
undetectable		 6brdA-3a21A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		4 / 7 ILE A  75
GLN A  78
VAL A  79
ILE A 130
 None
 0.94A 6cduF-3a21A:
2.2
6cduG-3a21A:
undetectable		 6cduF-3a21A:
19.24
6cduG-3a21A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FU4_B_HSMB401_1
(PROBABLE CHEMOTAXIS
TRANSDUCER)		 3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE
(Streptomyces
avermitilis) 		5 / 9 GLU A 165
GLU A 193
TYR A 151
TYR A 150
ASP A 146
 None
 1.47A 6fu4B-3a21A:
0.0		 6fu4B-3a21A:
8.50