SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A  89
ASP A 102
ASN A 155
 None
None
SAM  A 250 (-3.6A)
 0.90A 1nbhA-3a27A:
14.5		 1nbhA-3a27A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A  89
ASP A 102
ASN A 155
 None
None
SAM  A 250 (-3.6A)
 0.89A 1nbhD-3a27A:
14.2		 1nbhD-3a27A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.54A 2zzmA-3a27A:
26.0		 2zzmA-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		6 / 12 ARG A  87
PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.86A 2zznA-3a27A:
26.4		 2zznA-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		6 / 12 ARG A  87
PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.79A 2zznB-3a27A:
25.7		 2zznB-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		6 / 12 PHE A 104
GLY A 106
ILE A 126
LYS A 128
ASN A 155
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.5A)
SAM  A 250 (-3.6A)
SAM  A 250 (-4.6A)
 0.67A 3a25A-3a27A:
31.1		 3a25A-3a27A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		8 / 12 SER A  80
ASN A  83
ARG A  87
PHE A 104
GLY A 106
ILE A 126
ASN A 155
PHE A 178
 SAM  A 250 (-4.3A)
SAM  A 250 (-3.8A)
SAM  A 250 (-4.7A)
SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.6A)
SAM  A 250 (-4.6A)
 0.57A 3a25A-3a27A:
31.1		 3a25A-3a27A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  78
GLU A 127
ASP A 154
 SAM  A 250 (-4.2A)
SAM  A 250 (-3.0A)
SAM  A 250 (-3.2A)
 0.85A 3a25A-3a27A:
31.1		 3a25A-3a27A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		12 / 12 SER A  80
ASN A  83
ARG A  87
PHE A 104
GLY A 106
TYR A 109
LYS A 128
ASN A 129
ASP A 154
ARG A 156
TYR A 171
PHE A 178
 SAM  A 250 (-4.3A)
SAM  A 250 (-3.8A)
SAM  A 250 (-4.7A)
SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
SAM  A 250 (-3.6A)
SAM  A 250 (-3.5A)
None
SAM  A 250 (-3.2A)
SAM  A 250 ( 4.7A)
SAM  A 250 (-4.1A)
SAM  A 250 (-4.6A)
 0.00A 3a27A-3a27A:
40.6		 3a27A-3a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		3 / 3 MET A  78
GLU A 127
ASN A 155
 SAM  A 250 (-4.2A)
SAM  A 250 (-3.0A)
SAM  A 250 (-3.6A)
 0.00A 3a27A-3a27A:
40.6		 3a27A-3a27A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 10 PHE A 104
ASN A 129
ALA A 132
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
None
SAM  A 250 ( 4.3A)
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.55A 3ay0A-3a27A:
26.2		 3ay0A-3a27A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 10 PHE A 104
GLY A 106
ASN A 129
ASP A 154
PHE A 178
 SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
None
SAM  A 250 (-3.2A)
SAM  A 250 (-4.6A)
 0.49A 3ay0B-3a27A:
26.1		 3ay0B-3a27A:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A 183
LEU A 160
LYS A 161
ARG A 156
 None
None
None
SAM  A 250 ( 4.7A)
 1.16A 3sudD-3a27A:
undetectable		 3sudD-3a27A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A 102
ALA A 125
ILE A 140
ILE A 107
PRO A 113
 None
 1.15A 3u7sB-3a27A:
undetectable		 3u7sB-3a27A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A 102
ALA A 125
ILE A 140
ILE A 107
PRO A 113
 None
 1.02A 3u7sA-3a27A:
undetectable		 3u7sA-3a27A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 222
PHE A 246
ARG A 210
PRO A 207
VAL A 227
 None
 1.47A 4b3aA-3a27A:
undetectable		 4b3aA-3a27A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 6 ILE A 107
ASN A 139
GLU A  58
VAL A  11
 None
 1.07A 4ejwB-3a27A:
undetectable		 4ejwB-3a27A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A  57
ILE A  35
VAL A  11
LEU A  37
 None
 0.99A 4em2A-3a27A:
undetectable		 4em2A-3a27A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A  98
GLY A 190
HIS A 193
ARG A 166
 None
 1.43A 4r82A-3a27A:
0.0
4r82B-3a27A:
0.0		 4r82A-3a27A:
19.71
4r82B-3a27A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A 168
ILE A  93
ARG A  89
GLU A  86
 None
 1.18A 4zzcE-3a27A:
undetectable		 4zzcE-3a27A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 147
VAL A 123
ALA A 125
GLY A 108
 None
 0.68A 5fpdA-3a27A:
undetectable		 5fpdA-3a27A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 147
VAL A 123
ALA A 125
GLY A 108
 None
 0.69A 5fpdB-3a27A:
undetectable		 5fpdB-3a27A:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3a27 UNCHARACTERIZED
PROTEIN MJ1557
(Methanocaldococc
us
jannaschii) 		5 / 11 PHE A 104
GLY A 106
GLU A 127
ASN A 129
ASP A 154
 SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
SAM  A 250 (-3.0A)
None
SAM  A 250 (-3.2A)
 0.45A 5hjiA-3a27A:
23.9		 5hjiA-3a27A:
31.78