SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 6 ALA C 168
SER C 110
ARG C 125
LEU C 172
None
0.84A 1gahA-3a28C:
undetectable
1gahA-3a28C:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 4 THR C 189
GLY C  10
ASP C  33
ALA C  89
NAD  C4300 (-2.6A)
None
NAD  C4300 (-3.0A)
NAD  C4300 ( 3.8A)
1.24A 1sg9A-3a28C:
6.3
1sg9A-3a28C:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
8 / 11 GLY C   9
ALA C  11
ASP C  33
LEU C  34
ASP C  61
VAL C  62
ALA C  89
VAL C 111
NAD  C4300 (-3.6A)
NAD  C4300 ( 4.0A)
NAD  C4300 (-3.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.7A)
NAD  C4300 (-3.6A)
NAD  C4300 ( 3.8A)
NAD  C4300 ( 4.4A)
0.35A 1uayA-3a28C:
31.0
1uayA-3a28C:
32.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
8 / 10 GLY C   9
ALA C  11
ASP C  33
LEU C  34
ASP C  61
VAL C  62
ALA C  89
VAL C 111
NAD  C4300 (-3.6A)
NAD  C4300 ( 4.0A)
NAD  C4300 (-3.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.7A)
NAD  C4300 (-3.6A)
NAD  C4300 ( 3.8A)
NAD  C4300 ( 4.4A)
0.38A 1uayB-3a28C:
30.8
1uayB-3a28C:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 GLY C   9
ASP C  33
ASP C  61
ASN C  88
ALA C  89
NAD  C4300 (-3.6A)
NAD  C4300 (-3.0A)
NAD  C4300 (-3.7A)
NAD  C4300 (-3.5A)
NAD  C4300 ( 3.8A)
0.90A 2bm9E-3a28C:
5.4
2bm9E-3a28C:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 GLY C   9
ALA C  11
LEU C  34
VAL C  62
THR C  63
NAD  C4300 (-3.6A)
NAD  C4300 ( 4.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.6A)
NAD  C4300 ( 4.1A)
0.67A 2nyuB-3a28C:
7.4
2nyuB-3a28C:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 8 PHE C 117
SER C 115
ALA C 160
LEU C 164
None
1.08A 2o01A-3a28C:
undetectable
2o01A-3a28C:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 7 ARG C 125
PHE C 127
PHE C  82
ILE C 136
None
1.08A 2zseA-3a28C:
undetectable
2zseA-3a28C:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 GLY C   9
GLY C  17
LEU C  34
GLN C  37
ALA C  89
NAD  C4300 (-3.6A)
None
NAD  C4300 ( 4.4A)
NAD  C4300 (-4.2A)
NAD  C4300 ( 3.8A)
0.86A 3douA-3a28C:
8.7
3douA-3a28C:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 11 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.26A 3mg0H-3a28C:
undetectable
3mg0I-3a28C:
undetectable
3mg0H-3a28C:
22.02
3mg0I-3a28C:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 LEU C  60
ILE C  72
ALA C  75
ILE C  29
GLY C  15
None
1.08A 3nxuA-3a28C:
undetectable
3nxuA-3a28C:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 GLY C   9
ILE C  18
ASP C  33
LEU C  34
ASP C  61
NAD  C4300 (-3.6A)
None
NAD  C4300 (-3.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.7A)
0.70A 3q87B-3a28C:
6.4
3q87B-3a28C:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 7 ILE C  29
GLU C  20
ALA C  51
ALA C  50
None
0.90A 3r9tB-3a28C:
1.7
3r9tB-3a28C:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 5 LEU C 172
ALA C 123
PHE C 127
ASN C 138
None
1.38A 3uq6A-3a28C:
6.6
3uq6A-3a28C:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 4 LEU C 172
ALA C 123
PHE C 127
ASN C 138
None
1.31A 3vaqA-3a28C:
6.3
3vaqA-3a28C:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 4 LEU C 172
ALA C 123
PHE C 127
ASN C 138
None
1.32A 3vasA-3a28C:
6.7
3vasA-3a28C:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 7 VAL C 229
VAL C 233
LEU C 236
VAL C  84
None
1.08A 4e1gB-3a28C:
undetectable
4e1gB-3a28C:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 10 PRO C 226
VAL C 229
ALA C 230
TYR C 182
GLY C  15
None
1.09A 4mmdA-3a28C:
undetectable
4mmdA-3a28C:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 11 GLY C   9
GLY C  10
ASP C  33
LEU C  34
ASP C  61
NAD  C4300 (-3.6A)
None
NAD  C4300 (-3.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.7A)
0.50A 4pghA-3a28C:
6.0
4pghA-3a28C:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.25A 4qvpH-3a28C:
undetectable
4qvpI-3a28C:
undetectable
4qvpH-3a28C:
22.89
4qvpI-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.25A 4qvpV-3a28C:
undetectable
4qvpW-3a28C:
undetectable
4qvpV-3a28C:
22.89
4qvpW-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 11 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.24A 4qw0H-3a28C:
undetectable
4qw0I-3a28C:
undetectable
4qw0H-3a28C:
22.89
4qw0I-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 11 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.24A 4qw0V-3a28C:
undetectable
4qw0W-3a28C:
undetectable
4qw0V-3a28C:
22.89
4qw0W-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.24A 4qw1H-3a28C:
undetectable
4qw1I-3a28C:
undetectable
4qw1H-3a28C:
22.89
4qw1I-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.24A 4qw1V-3a28C:
undetectable
4qw1W-3a28C:
undetectable
4qw1V-3a28C:
22.89
4qw1W-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 11 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.24A 5bxnV-3a28C:
undetectable
5bxnW-3a28C:
undetectable
5bxnV-3a28C:
21.91
5bxnW-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.26A 5cz7V-3a28C:
undetectable
5cz7W-3a28C:
undetectable
5cz7V-3a28C:
22.89
5cz7W-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
4 / 7 ALA C 230
VAL C 229
TYR C 182
VAL C   7
None
0.84A 5ecoD-3a28C:
undetectable
5ecoD-3a28C:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.25A 5l66H-3a28C:
undetectable
5l66I-3a28C:
undetectable
5l66H-3a28C:
22.89
5l66I-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 THR C  44
ALA C  11
GLY C  10
THR C   8
ALA C  32
None
NAD  C4300 ( 4.0A)
None
None
None
1.25A 5l66V-3a28C:
undetectable
5l66W-3a28C:
undetectable
5l66V-3a28C:
22.89
5l66W-3a28C:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 ALA C 123
VAL C 179
ILE C 136
LEU C 172
ALA C 168
None
0.75A 5mo4A-3a28C:
undetectable
5mo4A-3a28C:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 9 VAL C   7
LEU C  22
ALA C  23
PHE C  27
VAL C  84
None
1.12A 5om2A-3a28C:
undetectable
5om2B-3a28C:
undetectable
5om2A-3a28C:
16.33
5om2B-3a28C:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 GLY C   9
GLY C  17
ASP C  33
LEU C  34
ASP C  61
NAD  C4300 (-3.6A)
None
NAD  C4300 (-3.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.7A)
0.81A 5yniA-3a28C:
5.1
5yniA-3a28C:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 12 GLY C   9
GLY C  17
ASP C  33
LEU C  34
ASP C  61
NAD  C4300 (-3.6A)
None
NAD  C4300 (-3.0A)
NAD  C4300 ( 4.4A)
NAD  C4300 (-3.7A)
0.81A 5ynmA-3a28C:
4.9
5ynmA-3a28C:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
3a28 L-2.3-BUTANEDIOL
DEHYDROGENASE

(Corynebacterium
glutamicum)
5 / 9 ALA C 183
SER C 141
VAL C 229
VAL C 187
GLY C 253
None
BME  C4462 ( 3.3A)
None
NAD  C4300 (-3.7A)
None
1.27A 6bklA-3a28C:
undetectable
6bklB-3a28C:
undetectable
6bklC-3a28C:
undetectable
6bklD-3a28C:
undetectable
6bklA-3a28C:
7.57
6bklB-3a28C:
7.57
6bklC-3a28C:
7.57
6bklD-3a28C:
7.57