SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a2f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 258
LEU A 322
VAL A 278
VAL A 263
 None
 1.02A 1e7aB-3a2fA:
undetectable		 1e7aB-3a2fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 413
LEU A 458
ARG A 364
PHE A 494
ILE A 414
 None
 1.26A 1g5yB-3a2fA:
undetectable		 1g5yB-3a2fA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3a2f DNA POLYMERASE
DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		4 / 7 THR A 767
SER A 768
SER B  44
ARG B  45
 None
 1.00A 1ibgL-3a2fA:
undetectable		 1ibgL-3a2fA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 GLY A 388
LEU A 409
TYR A 410
THR A 386
GLY A 387
 None
 1.48A 1kvlA-3a2fA:
undetectable		 1kvlA-3a2fA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3a2f DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		4 / 7 PHE B 157
VAL B 208
VAL B 136
ILE B 219
 None
 0.97A 1p7rA-3a2fB:
undetectable		 1p7rA-3a2fB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 4 ILE A 256
ASP A   6
LEU A 121
ARG A 346
 None
 1.44A 2a7qA-3a2fA:
undetectable		 2a7qA-3a2fA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 406
LEU A 572
PRO A 436
GLU A 523
 None
 1.06A 2jn3A-3a2fA:
undetectable		 2jn3A-3a2fA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3a2f DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		5 / 11 LEU B 141
ILE B 155
VAL B 201
LEU B 204
VAL B 208
 None
 0.92A 2kawA-3a2fB:
undetectable		 2kawA-3a2fB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 12 PHE A 442
PRO A 411
ALA A 491
ALA A 435
ALA A 516
 None
 1.18A 2x2nB-3a2fA:
undetectable		 2x2nB-3a2fA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 732
ILE A 663
ASP A 615
TRP A 616
 None
 1.14A 2x45C-3a2fA:
undetectable		 2x45C-3a2fA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 None
 0.71A 2zulA-3a2fA:
undetectable		 2zulA-3a2fA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 732
ILE A 663
ASP A 615
TRP A 616
 None
 1.10A 3bu1A-3a2fA:
undetectable		 3bu1A-3a2fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		3 / 3 SER A 493
GLU A 330
ASP A 259
 None
 0.70A 3dmhA-3a2fA:
undetectable		 3dmhA-3a2fA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 3a2f DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		4 / 4 GLU B 174
GLY B 170
THR B 172
GLU B 171
 None
 1.27A 3e9xA-3a2fB:
undetectable		 3e9xA-3a2fB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 540
GLY A 544
PHE A 564
LEU A 578
 None
 0.85A 3v7pA-3a2fA:
undetectable		 3v7pA-3a2fA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.33A 4cwxA-3a2fA:
undetectable
4cwxB-3a2fA:
4.1		 4cwxA-3a2fA:
20.21
4cwxB-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 537
TRP A 526
PHE A 564
GLU A 530
 None
 1.32A 4cwyA-3a2fA:
4.0
4cwyB-3a2fA:
4.1		 4cwyA-3a2fA:
20.21
4cwyB-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.32A 4cwyA-3a2fA:
4.0
4cwyB-3a2fA:
4.1		 4cwyA-3a2fA:
20.21
4cwyB-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a2f DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		4 / 6 PHE B 157
MET B 227
ILE B 155
VAL B 208
 None
 1.31A 4mk4B-3a2fB:
undetectable		 4mk4B-3a2fB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 500
LYS A 502
PRO A 372
LEU A 381
 None
 1.48A 4w5qA-3a2fA:
undetectable		 4w5qA-3a2fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 654
PRO A 723
LEU A 661
TYR A 721
 None
 1.04A 4w5qA-3a2fA:
undetectable		 4w5qA-3a2fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 361
LEU A 457
LEU A 357
LEU A 453
ARG A 359
 None
 1.44A 4x30A-3a2fA:
undetectable		 4x30A-3a2fA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 6 TYR A 654
PRO A 723
LEU A 661
TYR A 721
 None
 1.04A 4z4cA-3a2fA:
undetectable		 4z4cA-3a2fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 4 LEU A 195
ILE A 198
PRO A 239
LEU A 219
 None
 1.19A 5eb3A-3a2fA:
undetectable		 5eb3A-3a2fA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 3a2f DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		4 / 4 VAL B 140
GLU B 139
GLY B 185
LEU B 179
 None
 1.25A 5g5gC-3a2fB:
undetectable		 5g5gC-3a2fB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 228
GLY A 227
PHE A 152
PHE A 214
 None
 0.80A 5hieD-3a2fA:
undetectable		 5hieD-3a2fA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 5 GLU A 659
GLU A 622
THR A 623
LEU A 651
 None
 1.27A 5hm8G-3a2fA:
undetectable		 5hm8G-3a2fA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
 None
 1.25A 5iqbA-3a2fA:
1.1		 5iqbA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.28A 5iqbA-3a2fA:
1.1		 5iqbA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		6 / 11 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.44A 5iqbB-3a2fA:
0.0		 5iqbB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
 None
 1.25A 5iqbC-3a2fA:
0.0		 5iqbC-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.35A 5iqbC-3a2fA:
0.0		 5iqbC-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		6 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.31A 5iqbD-3a2fA:
1.6		 5iqbD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
 None
 1.48A 5iqcB-3a2fA:
0.0		 5iqcB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.36A 5iqcB-3a2fA:
0.0		 5iqcB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 141
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.49A 5iqcD-3a2fA:
0.0		 5iqcD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
ASP A 141
GLU A 288
GLU A 294
TYR A 291
 None
 1.07A 5iqcD-3a2fA:
0.0		 5iqcD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.39A 5iqdA-3a2fA:
1.1		 5iqdA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.40A 5iqdB-3a2fA:
2.3		 5iqdB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.34A 5iqdD-3a2fA:
3.1		 5iqdD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
ASP A 141
GLU A 288
GLU A 294
TYR A 291
 None
 1.21A 5iqeA-3a2fA:
1.2		 5iqeA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
 None
 1.47A 5iqeA-3a2fA:
1.2		 5iqeA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
ASP A 141
GLU A 288
GLU A 294
TYR A 291
 None
 1.11A 5iqeB-3a2fA:
3.1		 5iqeB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
 None
 1.47A 5iqeB-3a2fA:
3.1		 5iqeB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		6 / 12 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.40A 5iqeD-3a2fA:
1.4		 5iqeD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
ASP A 141
TYR A 311
GLU A 288
GLU A 294
 None
 1.49A 5iqgA-3a2fA:
0.5		 5iqgA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.40A 5iqgA-3a2fA:
0.5		 5iqgA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.44A 5iqgC-3a2fA:
1.3		 5iqgC-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 663
TYR A 702
GLU A 735
ALA A 715
ILE A 656
 None
 1.43A 5iwuA-3a2fA:
undetectable		 5iwuA-3a2fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3a2f DNA POLYMERASE
SLIDING CLAMP
(Pyrococcus
furiosus) 		4 / 8 LEU B 179
ILE B 177
PHE B 164
ALA B 144
 None
 1.03A 5m0oC-3a2fB:
undetectable		 5m0oC-3a2fB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 VAL A 604
LEU A 609
ALA A 596
GLY A 635
LEU A 397
 None
 1.27A 5m5cE-3a2fA:
undetectable		 5m5cE-3a2fA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 4 ARG A 196
ILE A 197
TYR A 162
ILE A 171
 None
 1.47A 5odhG-3a2fA:
undetectable		 5odhG-3a2fA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.37A 5uo9A-3a2fA:
undetectable
5uo9B-3a2fA:
undetectable		 5uo9A-3a2fA:
19.51
5uo9B-3a2fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.42A 5uo9C-3a2fA:
0.0
5uo9D-3a2fA:
0.0		 5uo9C-3a2fA:
19.51
5uo9D-3a2fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 537
TRP A 526
PHE A 564
GLU A 530
 None
 1.39A 5vv9A-3a2fA:
undetectable
5vv9B-3a2fA:
4.1		 5vv9A-3a2fA:
20.21
5vv9B-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 537
TRP A 526
PHE A 564
GLU A 530
 None
 1.32A 5vvaA-3a2fA:
undetectable
5vvaB-3a2fA:
undetectable		 5vvaA-3a2fA:
20.21
5vvaB-3a2fA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.36A 5vvdA-3a2fA:
undetectable
5vvdB-3a2fA:
undetectable		 5vvdA-3a2fA:
19.51
5vvdB-3a2fA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 168
SER A 161
ILE A 206
THR A 208
ILE A 232
 None
 1.12A 5y80A-3a2fA:
undetectable		 5y80A-3a2fA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 141
SER A 161
ILE A 206
THR A 208
ILE A 232
 None
 1.23A 5y80A-3a2fA:
undetectable		 5y80A-3a2fA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.33A 6av6A-3a2fA:
0.0
6av6B-3a2fA:
undetectable		 6av6A-3a2fA:
6.60
6av6B-3a2fA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.36A 6c5uA-3a2fA:
0.0		 6c5uA-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 9 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.38A 6c5uB-3a2fA:
0.0		 6c5uB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.27A 6c5uD-3a2fA:
3.1		 6c5uD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 11 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.28A 6cggD-3a2fA:
1.3		 6cggD-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 TRP A 526
PHE A 564
GLU A 530
VAL A 537
 None
 1.35A 6cieA-3a2fA:
undetectable
6cieB-3a2fA:
undetectable		 6cieA-3a2fA:
6.60
6cieB-3a2fA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 537
TRP A 526
PHE A 564
GLU A 530
 None
 1.38A 6cifC-3a2fA:
0.0
6cifD-3a2fA:
0.0		 6cifC-3a2fA:
6.60
6cifD-3a2fA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3a2f DNA POLYMERASE
(Pyrococcus
furiosus) 		5 / 10 LEU A 545
VAL A 565
VAL A 402
ALA A 561
LEU A 578
 None
 1.03A 6czmA-3a2fA:
3.8
6czmC-3a2fA:
undetectable		 6czmA-3a2fA:
18.84
6czmC-3a2fA:
18.84