SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a2k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 5 SER A  26
SER A  31
PHE A 111
VAL A  70
 None
 1.28A 1oipA-3a2kA:
undetectable		 1oipA-3a2kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 ALA A 124
TYR A 122
ILE A   9
PRO A 166
 None
 1.17A 1oniB-3a2kA:
undetectable
1oniC-3a2kA:
undetectable		 1oniB-3a2kA:
17.18
1oniC-3a2kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 ALA A 124
TYR A 122
ILE A   9
PRO A 166
 None
 1.12A 1oniH-3a2kA:
undetectable
1oniI-3a2kA:
undetectable		 1oniH-3a2kA:
17.18
1oniI-3a2kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A 140
LEU A 137
LEU A 217
ARG A 211
THR A 145
 None
 1.10A 1zucB-3a2kA:
undetectable		 1zucB-3a2kA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 ARG A 203
ASP A 131
ILE A 152
TYR A 108
 C  C  35 ( 3.9A)
C  C  35 ( 4.0A)
A  C  36 ( 4.7A)
A  C  36 ( 3.8A)
 1.15A 2ya7C-3a2kA:
undetectable		 2ya7C-3a2kA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 151
GLY A 148
VAL A 154
HIS A  12
SER A 225
 None
A  C  38 ( 4.1A)
None
None
None
 1.34A 3dlcA-3a2kA:
undetectable		 3dlcA-3a2kA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 5 ASP A  55
GLU A  62
GLY A  60
ASP A  87
 None
 0.88A 3w9tD-3a2kA:
undetectable		 3w9tD-3a2kA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 SER A  31
ASP A  30
ASP A 189
GLU A  66
 None
 1.25A 4eysA-3a2kA:
2.1		 4eysA-3a2kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 7 GLN A 212
LEU A 217
THR A 135
MET A 138
 None
None
A  C  36 ( 4.8A)
C  C  35 ( 3.4A)
 0.89A 4mbsA-3a2kA:
undetectable		 4mbsA-3a2kA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		3 / 3 PRO A 286
VAL A 291
HIS A 295
 None
C  C  26 ( 4.6A)
G  C  25 ( 4.5A)
 0.85A 4pevC-3a2kA:
2.5		 4pevC-3a2kA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 VAL A 374
ASP A 376
PRO A 377
ALA A 446
 None
 0.66A 5cu6A-3a2kA:
undetectable		 5cu6A-3a2kA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_DIFA601_1
(SERUM ALBUMIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		5 / 9 ASP A 241
ALA A 239
VAL A 272
ARG A 271
LYS A 245
 None
 1.45A 5dbyA-3a2kA:
0.0		 5dbyA-3a2kA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 4 GLY A 333
ALA A 330
MET A 418
THR A 327
 None
 1.47A 5n0sB-3a2kA:
2.4		 5n0sB-3a2kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 7 VAL A 374
ASP A 376
PRO A 377
ALA A 446
 None
 0.66A 5ospA-3a2kA:
undetectable		 5ospA-3a2kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 7 VAL A 374
ASP A 376
PRO A 377
ALA A 446
 None
 0.69A 5osrA-3a2kA:
undetectable		 5osrA-3a2kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		4 / 5 VAL A 374
ASP A 376
PRO A 377
ALA A 446
 None
 0.66A 5otrA-3a2kA:
undetectable		 5otrA-3a2kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3a2k TRNA(ILE)-LYSIDINE
SYNTHASE
(Geobacillus
kaustophilus) 		3 / 3 ARG A 172
ARG A 211
ASP A 130
 None
 0.79A 6d8pA-3a2kA:
undetectable		 6d8pA-3a2kA:
21.51