SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 8 TYR A 242
VAL A 120
GLY A 105
THR A 106
ALA A 101
 None
 1.36A 2a1hA-3a2lA:
undetectable
2a1hB-3a2lA:
undetectable		 2a1hA-3a2lA:
21.18
2a1hB-3a2lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 10 GLY A 105
THR A 106
ALA A 101
TYR A 242
VAL A 120
 None
 1.39A 2coiA-3a2lA:
undetectable
2coiB-3a2lA:
undetectable		 2coiA-3a2lA:
22.25
2coiB-3a2lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 10 TYR A 242
VAL A 120
GLY A 105
THR A 106
ALA A 101
 None
 1.38A 2coiA-3a2lA:
undetectable
2coiB-3a2lA:
undetectable		 2coiA-3a2lA:
22.25
2coiB-3a2lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 11 GLY A 105
THR A 106
ALA A 101
TYR A 242
VAL A 120
 None
 1.41A 2cojA-3a2lA:
undetectable
2cojB-3a2lA:
undetectable		 2cojA-3a2lA:
22.25
2cojB-3a2lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 9 TYR A 242
VAL A 120
GLY A 105
THR A 106
ALA A 101
 None
 1.39A 2cojA-3a2lA:
undetectable
2cojB-3a2lA:
undetectable		 2cojA-3a2lA:
22.25
2cojB-3a2lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 12 HIS A  36
SER A  41
HIS A  81
ARG A 208
PRO A 209
 None
 1.36A 2fj1A-3a2lA:
undetectable		 2fj1A-3a2lA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		4 / 5 GLY A 183
GLY A 184
PHE A 160
PHE A 176
 None
None
None
CL  A 401 ( 4.8A)
 1.06A 2qr2A-3a2lA:
2.4
2qr2B-3a2lA:
undetectable		 2qr2A-3a2lA:
22.50
2qr2B-3a2lA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TCT_A_CTCA222_0
(TETRACYCLINE
REPRESSOR)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 12 HIS A  36
SER A  41
HIS A  81
ARG A 208
PRO A 209
 None
 1.30A 2tctA-3a2lA:
0.0		 2tctA-3a2lA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TRT_A_TACA222_1
(TETRACYCLINE
REPRESSOR CLASS D)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 11 HIS A  36
SER A  41
HIS A  81
ARG A 208
PRO A 209
 None
 1.38A 2trtA-3a2lA:
0.0		 2trtA-3a2lA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 12 PHE A 128
VAL A 255
ALA A 235
ALA A 238
THR A 268
 None
 1.33A 2x2nC-3a2lA:
undetectable		 2x2nC-3a2lA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 11 GLY A  67
GLY A  70
HIS A  81
PRO A 209
ILE A  64
 None
 1.30A 2y7kA-3a2lA:
undetectable		 2y7kA-3a2lA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 10 GLY A  67
GLY A  70
HIS A  81
PRO A 209
ILE A  64
 None
 1.34A 2y7pA-3a2lA:
undetectable		 2y7pA-3a2lA:
24.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		8 / 9 ASN A  38
ASP A 103
TRP A 104
PHE A 157
PHE A 176
LEU A 217
HIS A 280
TYR A 281
 CL  A 401 (-4.4A)
CL  A 401 ( 4.9A)
CL  A 401 (-4.6A)
None
CL  A 401 ( 4.8A)
CL  A 401 ( 4.8A)
None
None
 0.35A 3fbwA-3a2lA:
46.7		 3fbwA-3a2lA:
51.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 9 ASP A 103
TRP A 104
PHE A 138
LEU A 217
HIS A 280
 CL  A 401 ( 4.9A)
CL  A 401 (-4.6A)
None
CL  A 401 ( 4.8A)
None
 1.30A 3fbwA-3a2lA:
46.7		 3fbwA-3a2lA:
51.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		3 / 3 PRO A 218
PHE A  78
ALA A 107
 None
 0.69A 3itaD-3a2lA:
undetectable		 3itaD-3a2lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		4 / 7 TYR A  76
HIS A  81
LEU A 171
PHE A 201
 None
 1.10A 3jwqC-3a2lA:
undetectable		 3jwqC-3a2lA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 12 ILE A  59
PHE A  88
LEU A  85
SER A  69
LEU A  63
 None
 1.15A 3k2hB-3a2lA:
undetectable		 3k2hB-3a2lA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		3 / 3 PHE A 157
GLN A 147
PHE A 176
 None
None
CL  A 401 ( 4.8A)
 0.81A 3rv5A-3a2lA:
undetectable		 3rv5A-3a2lA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		3 / 3 TYR A  21
LEU A  51
ARG A  22
 None
 0.72A 3sufB-3a2lA:
undetectable		 3sufB-3a2lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		3 / 3 PHE A  79
ASP A  86
ARG A 115
 None
 0.89A 4eahF-3a2lA:
1.1		 4eahF-3a2lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		3 / 3 PHE A  79
ASP A  86
ARG A 115
 None
 0.89A 4eahG-3a2lA:
1.8		 4eahG-3a2lA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		8 / 8 ASN A  38
ASP A 103
TRP A 104
PHE A 176
VAL A 180
LEU A 217
HIS A 280
TYR A 281
 CL  A 401 (-4.4A)
CL  A 401 ( 4.9A)
CL  A 401 (-4.6A)
CL  A 401 ( 4.8A)
None
CL  A 401 ( 4.8A)
None
None
 0.32A 4f5zA-3a2lA:
47.1		 4f5zA-3a2lA:
52.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		4 / 8 ASP A 103
TRP A 104
PHE A 157
HIS A 280
 CL  A 401 ( 4.9A)
CL  A 401 (-4.6A)
None
None
 1.10A 4f5zA-3a2lA:
47.1		 4f5zA-3a2lA:
52.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 12 LEU A 275
GLY A 184
LEU A 181
MET A 126
GLU A 284
 None
 1.43A 5emlA-3a2lA:
undetectable		 5emlA-3a2lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		5 / 12 LEU A 275
GLY A 184
PRO A 182
LEU A 181
GLU A 284
 None
 1.44A 5emlA-3a2lA:
undetectable		 5emlA-3a2lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3a2l HALOALKANE
DEHALOGENASE
(Bradyrhizobium
japonicum) 		4 / 8 GLY A  37
GLY A 105
LEU A 108
ALA A 107
 None
 0.75A 5vw5A-3a2lA:
undetectable		 5vw5A-3a2lA:
20.68