SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a31'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 ALA A  13
PHE A  44
SER A 316
ILE A 317
LEU A  55
 None
 1.20A 1dlsA-3a31A:
undetectable		 1dlsA-3a31A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 ALA A  13
LEU A 154
PHE A  44
ILE A 317
LEU A  55
 None
 1.05A 1drfA-3a31A:
undetectable		 1drfA-3a31A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 GLY A 258
ALA A 255
SER A 207
ALA A 228
ASP A 284
 None
 1.04A 1nt2A-3a31A:
undetectable		 1nt2A-3a31A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		6 / 10 MET A 110
CYH A 112
ARG A 144
ASP A 164
HIS A 166
HIS A 310
 None
ZN  A 743 (-2.4A)
None
ZN  A 743 ( 4.1A)
ZN  A 743 (-3.2A)
ZN  A 743 (-3.0A)
 0.79A 1nyrA-3a31A:
33.7		 1nyrA-3a31A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		6 / 10 MET A 110
CYH A 112
ARG A 144
ASP A 164
HIS A 166
HIS A 310
 None
ZN  A 743 (-2.4A)
None
ZN  A 743 ( 4.1A)
ZN  A 743 (-3.2A)
ZN  A 743 (-3.0A)
 0.69A 1nyrB-3a31A:
5.6		 1nyrB-3a31A:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 6 MET A 185
VAL A 188
LEU A 189
MET A 265
 None
 0.88A 1x8vA-3a31A:
undetectable		 1x8vA-3a31A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 11 ARG A 311
ILE A 309
ILE A 308
PHE A 283
TYR A 257
 None
 1.19A 2azyA-3a31A:
undetectable		 2azyA-3a31A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 5 LEU A 195
LEU A 206
MET A 266
ARG A 238
 None
 0.91A 2oiqA-3a31A:
undetectable		 2oiqA-3a31A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 8 LEU A 154
PRO A 338
GLY A 330
MET A 332
 None
 0.97A 2qd5B-3a31A:
5.4		 2qd5B-3a31A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 9 ILE A  18
LEU A 154
GLY A 322
TYR A 152
THR A 161
 None
 0.82A 2tsrD-3a31A:
undetectable		 2tsrD-3a31A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 10 ALA A  13
LEU A 154
ILE A  51
SER A 316
ILE A 317
 None
 1.13A 2w9sC-3a31A:
undetectable		 2w9sC-3a31A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 6 ASP A 180
ARG A 173
VAL A 169
ILE A 167
 None
 1.18A 2yfbB-3a31A:
undetectable		 2yfbB-3a31A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 LEU A 187
LEU A 325
ILE A  18
MET A 332
VAL A  58
 None
 1.02A 2ygnA-3a31A:
undetectable		 2ygnA-3a31A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 11 PHE A 334
ARG A 454
SER A 451
PHE A 372
VAL A 401
 None
 1.30A 3a9eB-3a31A:
undetectable		 3a9eB-3a31A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		3 / 3 GLU A 138
HIS A 115
THR A  73
 None
 0.80A 3hkuA-3a31A:
undetectable		 3hkuA-3a31A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 GLY A 258
ALA A 255
SER A 207
ALA A 228
ASP A 284
 None
 0.96A 3id6C-3a31A:
undetectable		 3id6C-3a31A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 GLY A 258
ALA A 255
SER A 207
ALA A 228
ASP A 284
 None
 0.92A 3nmuA-3a31A:
undetectable
3nmuF-3a31A:
undetectable		 3nmuA-3a31A:
23.51
3nmuF-3a31A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 11 ALA A 438
ASP A 437
VAL A 445
VAL A 343
ILE A 363
 None
 1.12A 3oxxB-3a31A:
undetectable		 3oxxB-3a31A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 ASP A 466
ILE A 344
ALA A 364
ALA A 375
ALA A 342
 None
 0.98A 3sudC-3a31A:
undetectable		 3sudC-3a31A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		3 / 3 SER A 212
PHE A 218
LYS A 216
 None
 0.95A 3u88A-3a31A:
undetectable		 3u88A-3a31A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 4 PRO A 333
LEU A 336
ILE A  51
ARG A  52
 None
 1.34A 3w1wA-3a31A:
5.0		 3w1wA-3a31A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 GLY A 366
ALA A 364
PHE A 372
ARG A 462
VAL A 439
 None
 1.26A 4azsA-3a31A:
undetectable		 4azsA-3a31A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 GLY A 366
ALA A 364
PHE A 372
ARG A 462
VAL A 439
 None
 1.26A 4azwA-3a31A:
undetectable		 4azwA-3a31A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 VAL A 177
VAL A 136
ALA A 231
PHE A 283
LEU A 287
 None
 1.17A 4ib4A-3a31A:
undetectable		 4ib4A-3a31A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 7 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.70A 4iqqA-3a31A:
undetectable		 4iqqA-3a31A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 8 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.80A 4iqqD-3a31A:
undetectable		 4iqqD-3a31A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 ALA A  13
LEU A 154
PHE A  44
ILE A 317
LEU A  55
 None
 1.01A 4m6kA-3a31A:
undetectable		 4m6kA-3a31A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		3 / 3 ARG A  52
GLU A  72
TYR A  53
 None
 0.87A 4r29D-3a31A:
undetectable		 4r29D-3a31A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 7 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.73A 5h3aB-3a31A:
undetectable		 5h3aB-3a31A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		3 / 3 ILE A  51
ILE A 463
MET A 332
 None
 0.65A 5i9yA-3a31A:
undetectable		 5i9yA-3a31A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 8 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.84A 5nooD-3a31A:
undetectable		 5nooD-3a31A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 10 MET A 278
LEU A 313
LEU A 187
PHE A 202
GLU A 183
 None
 1.42A 5tixB-3a31A:
undetectable		 5tixB-3a31A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 6 PRO A 452
PRO A 333
LEU A 336
PHE A 334
 None
 1.02A 5tl8A-3a31A:
undetectable		 5tl8A-3a31A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		5 / 12 ILE A  18
LEU A 154
GLY A 322
TYR A 152
THR A 161
 None
 0.76A 5x5qB-3a31A:
undetectable		 5x5qB-3a31A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1
(Aeropyrum
pernix) 		4 / 6 ILE A  18
LEU A 154
GLY A 322
TYR A 152
 None
 0.74A 5x5qE-3a31A:
undetectable		 5x5qE-3a31A:
19.53