SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a3j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3a3j PBP5
(Haemophilus
influenzae) 		4 / 4 THR A 287
LEU A 288
LEU A 309
GLN A 297
 None
 1.16A 1fbmA-3a3jA:
undetectable		 1fbmA-3a3jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
LYS A  68
SER A 128
ASN A 130
GLY A 233
 None
None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.5A)
 0.58A 1ghmA-3a3jA:
21.7		 1ghmA-3a3jA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 12 GLY A 129
ALA A 132
VAL A 115
ILE A  92
GLY A  98
 None
 1.06A 1hsgB-3a3jA:
undetectable		 1hsgB-3a3jA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
LYS A  68
SER A 128
ASN A 130
GLY A 233
 None
None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.5A)
 0.62A 1i2wA-3a3jA:
22.4		 1i2wA-3a3jA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
LYS A  68
SER A 128
ASN A 130
GLY A 233
 None
None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.5A)
 0.57A 1i2wB-3a3jA:
22.5		 1i2wB-3a3jA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
LYS A  68
SER A 128
GLY A 233
ARG A 267
 None
None
None
SO4  A   1 ( 4.8A)
SO4  A   1 (-3.5A)
SO4  A   1 (-3.0A)
 0.95A 1i2wB-3a3jA:
22.5		 1i2wB-3a3jA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3a3j PBP5
(Haemophilus
influenzae) 		3 / 3 GLU A 268
ASN A 217
TRP A 221
 None
 1.18A 1r15C-3a3jA:
undetectable		 1r15C-3a3jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3a3j PBP5
(Haemophilus
influenzae) 		3 / 3 GLU A 268
ASN A 217
TRP A 221
 None
 1.20A 1r15E-3a3jA:
undetectable		 1r15E-3a3jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3a3j PBP5
(Haemophilus
influenzae) 		3 / 3 GLU A 268
ASN A 217
TRP A 221
 None
 1.25A 1r15F-3a3jA:
undetectable		 1r15F-3a3jA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3a3j PBP5
(Haemophilus
influenzae) 		3 / 3 GLU A 283
THR A 284
LEU A  52
 None
 0.68A 1v8bC-3a3jA:
undetectable		 1v8bC-3a3jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 12 GLY A 129
ALA A 132
VAL A 115
ILE A  92
GLY A  98
 None
 1.06A 2avsB-3a3jA:
undetectable		 2avsB-3a3jA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 7 ILE A 255
ARG A 253
PRO A  34
GLY A 278
TRP A 277
 None
 1.34A 2pnjB-3a3jA:
undetectable		 2pnjB-3a3jA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
LYS A  68
THR A 232
GLY A 233
THR A 235
ARG A 267
 None
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
None
SO4  A   1 (-3.0A)
 0.90A 3mzeA-3a3jA:
47.1		 3mzeA-3a3jA:
55.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3a3j PBP5
(Haemophilus
influenzae) 		7 / 12 ALA A  64
SER A  65
LYS A  68
ASN A 130
THR A 232
GLY A 233
ARG A 267
 None
None
None
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
SO4  A   1 (-3.0A)
 0.52A 3mzeA-3a3jA:
47.1		 3mzeA-3a3jA:
55.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 12 GLY A 129
ALA A 132
VAL A 115
ILE A  92
GLY A  98
 None
 1.10A 3nu5B-3a3jA:
undetectable		 3nu5B-3a3jA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
SER A 128
ASN A 130
THR A 232
GLY A 233
 None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
 0.60A 3sh8A-3a3jA:
22.7		 3sh8A-3a3jA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 11 LEU A  66
SER A 178
ILE A 191
ILE A 255
VAL A 257
 None
 1.10A 3w67A-3a3jA:
undetectable		 3w67A-3a3jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 12 LEU A  66
SER A 178
ILE A 191
ILE A 255
VAL A 257
 None
 1.08A 3w67D-3a3jA:
undetectable		 3w67D-3a3jA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3a3j PBP5
(Haemophilus
influenzae) 		4 / 8 GLY A 291
GLY A 310
TYR A 331
LEU A 365
 None
 0.79A 4fgzA-3a3jA:
undetectable		 4fgzA-3a3jA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3a3j PBP5
(Haemophilus
influenzae) 		4 / 8 GLY A 291
GLY A 310
TYR A 331
LEU A 365
 None
 0.81A 4fgzB-3a3jA:
undetectable		 4fgzB-3a3jA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
SER A 128
ASN A 130
THR A 232
GLY A 233
 None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
 0.61A 4n9kA-3a3jA:
22.5		 4n9kA-3a3jA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 12 ALA A  64
SER A  65
SER A 128
ASN A 130
THR A 232
GLY A 233
 None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
 0.63A 4n9kB-3a3jA:
22.3		 4n9kB-3a3jA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3a3j PBP5
(Haemophilus
influenzae) 		5 / 12 LEU A  66
GLY A 218
LEU A 219
VAL A 227
VAL A 257
 None
 1.10A 4wnwB-3a3jA:
undetectable		 4wnwB-3a3jA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 11 ALA A  64
SER A  65
SER A 128
ASN A 130
THR A 232
GLY A 233
 None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
 0.62A 5ghzA-3a3jA:
22.2		 5ghzA-3a3jA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 3a3j PBP5
(Haemophilus
influenzae) 		6 / 10 ALA A  64
SER A  65
SER A 128
ASN A 130
THR A 232
GLY A 233
 None
None
SO4  A   1 ( 4.8A)
None
SO4  A   1 (-3.6A)
SO4  A   1 (-3.5A)
 0.63A 5ghzB-3a3jA:
22.3		 5ghzB-3a3jA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3a3j PBP5
(Haemophilus
influenzae) 		4 / 5 THR A 235
HIS A 234
ALA A  64
ASP A 172
 None
SO4  A   1 (-3.7A)
None
None
 1.16A 5mfxA-3a3jA:
undetectable		 5mfxA-3a3jA:
20.60