SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3a4r NFATC2-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 12 LEU A  -2
ALA A 398
ASP A 361
ILE A 356
LEU A 343
 None
 0.97A 1tw4A-3a4rA:
undetectable		 1tw4A-3a4rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3a4r NFATC2-INTERACTING
PROTEIN
(Mus
musculus) 		6 / 12 LEU A 341
LEU A  -2
ALA A 398
ASP A 361
ILE A 356
LEU A 343
 None
 1.18A 2jn3A-3a4rA:
undetectable		 2jn3A-3a4rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3a4r NFATC2-INTERACTING
PROTEIN
(Mus
musculus) 		4 / 8 LEU A 367
GLU A 395
LEU A 400
LEU A 341
 None
 1.23A 5dxeA-3a4rA:
undetectable		 5dxeA-3a4rA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3a4r NFATC2-INTERACTING
PROTEIN
(Mus
musculus) 		4 / 8 LEU A 367
GLU A 395
LEU A 400
LEU A 341
 None
 1.22A 6cbzA-3a4rA:
undetectable		 6cbzA-3a4rA:
26.44