SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.46A 1eizA-3a4tA:
14.2		 1eizA-3a4tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  94
GLY A  95
GLY A  96
ARG A 144
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
None
None
 0.42A 1ej0A-3a4tA:
11.7		 1ej0A-3a4tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.44A 1nsiA-3a4tA:
undetectable
1nsiB-3a4tA:
undetectable		 1nsiA-3a4tA:
19.82
1nsiB-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A 267
GLU A 221
ARG A 258
ILE A 253
 None
 1.49A 1nsiA-3a4tA:
undetectable
1nsiB-3a4tA:
undetectable		 1nsiA-3a4tA:
19.82
1nsiB-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.47A 1nsiC-3a4tA:
undetectable
1nsiD-3a4tA:
undetectable		 1nsiC-3a4tA:
19.82
1nsiD-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 192
ARG A 230
LYS A 273
ASP A 232
 None
 1.45A 1rrjA-3a4tA:
0.9		 1rrjA-3a4tA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		8 / 12 CYH A  91
ALA A  93
GLY A  95
GLY A  96
LYS A  97
ILE A 116
ARG A 144
PRO A 165
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.9A)
 0.58A 1sqfA-3a4tA:
28.8		 1sqfA-3a4tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		8 / 12 CYH A  91
ALA A  93
GLY A  95
GLY A  96
LYS A  97
ILE A 116
ASP A 142
ARG A 144
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-4.0A)
None
 0.58A 1sqfA-3a4tA:
28.8		 1sqfA-3a4tA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 CYH A  91
PRO A  94
GLY A  95
LYS A  97
ASP A 142
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-4.0A)
 0.31A 2b9eA-3a4tA:
28.7		 2b9eA-3a4tA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  89
ALA A  93
ILE A 116
SER A 117
ASP A 163
 SFG  A 500 ( 4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.7A)
 0.82A 2ejtA-3a4tA:
11.4		 2ejtA-3a4tA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.42A 2nsiA-3a4tA:
1.2
2nsiB-3a4tA:
undetectable		 2nsiA-3a4tA:
19.82
2nsiB-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 267
GLU A 221
ARG A 258
ILE A 253
 None
 1.44A 2nsiA-3a4tA:
1.2
2nsiB-3a4tA:
undetectable		 2nsiA-3a4tA:
19.82
2nsiB-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.45A 2nsiC-3a4tA:
undetectable
2nsiD-3a4tA:
undetectable		 2nsiC-3a4tA:
19.82
2nsiD-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 267
GLU A 221
ARG A 258
ILE A 253
 None
 1.44A 2nsiC-3a4tA:
undetectable
2nsiD-3a4tA:
undetectable		 2nsiC-3a4tA:
19.82
2nsiD-3a4tA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  65
GLY A  63
GLY A 132
THR A  57
ASN A 127
 None
 1.11A 2okcA-3a4tA:
11.2		 2okcA-3a4tA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A  35
ILE A  54
GLY A  55
LEU A  61
 None
 0.92A 3bjwF-3a4tA:
undetectable		 3bjwF-3a4tA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A  35
ILE A  54
GLY A  55
LEU A  61
 None
 0.90A 3bjwH-3a4tA:
undetectable		 3bjwH-3a4tA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.44A 3e7gA-3a4tA:
undetectable
3e7gB-3a4tA:
undetectable		 3e7gA-3a4tA:
20.42
3e7gB-3a4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 PHE A 267
GLU A 221
ARG A 258
ILE A 253
 None
 1.46A 3e7gA-3a4tA:
undetectable
3e7gB-3a4tA:
undetectable		 3e7gA-3a4tA:
20.42
3e7gB-3a4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.42A 3e7gC-3a4tA:
undetectable
3e7gD-3a4tA:
undetectable		 3e7gC-3a4tA:
20.42
3e7gD-3a4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 8 PHE A 267
GLU A 221
ARG A 258
ILE A 253
 None
 1.44A 3e7gC-3a4tA:
undetectable
3e7gD-3a4tA:
undetectable		 3e7gC-3a4tA:
20.42
3e7gD-3a4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 LYS A  97
ARG A 120
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-2.8A)
SFG  A 500 (-4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 3m6vA-3a4tA:
31.3		 3m6vA-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  95
GLY A  96
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.47A 3m6vA-3a4tA:
31.3		 3m6vA-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  96
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.05A 3m6vB-3a4tA:
31.1		 3m6vB-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 LYS A  97
ARG A 120
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-2.8A)
SFG  A 500 (-4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 3m6vB-3a4tA:
31.1		 3m6vB-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  95
GLY A  96
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.47A 3m6vB-3a4tA:
31.1		 3m6vB-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 PRO A  94
GLY A  95
GLY A  96
LYS A  97
PRO A 165
LEU A 193
 SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.9A)
None
 0.46A 3m6wA-3a4tA:
31.2		 3m6wA-3a4tA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 162
ILE A 268
PRO A  75
PHE A 266
 None
 1.14A 3s3vA-3a4tA:
2.2		 3s3vA-3a4tA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 241
ALA A 240
GLY A 255
ILE A 237
 None
 0.83A 3spkB-3a4tA:
undetectable		 3spkB-3a4tA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  79
PHE A  86
GLY A 197
LEU A 200
ASP A 158
 None
 1.27A 3tbgA-3a4tA:
undetectable		 3tbgA-3a4tA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  79
PHE A  86
GLY A 197
LEU A 200
ASP A 158
 None
 1.27A 3tbgC-3a4tA:
undetectable		 3tbgC-3a4tA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		3 / 3 PRO A  81
ASP A  85
GLU A  83
 None
 0.73A 3v4tC-3a4tA:
0.0		 3v4tC-3a4tA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A 136
LEU A 124
GLY A  95
THR A  99
VAL A 133
 None
None
SFG  A 500 (-4.0A)
None
None
 1.38A 4c9kB-3a4tA:
undetectable		 4c9kB-3a4tA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.05A 4fp9A-3a4tA:
26.3		 4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.50A 4fp9A-3a4tA:
26.3		 4fp9A-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 4fp9C-3a4tA:
26.3		 4fp9C-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.50A 4fp9C-3a4tA:
26.3		 4fp9C-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 CYH A  91
GLY A  95
LYS A  97
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.9A)
None
 1.06A 4fp9D-3a4tA:
26.4		 4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
 0.68A 4fp9D-3a4tA:
26.4		 4fp9D-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		6 / 12 CYH A  91
GLY A  95
LYS A  97
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-2.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 1.02A 4fp9F-3a4tA:
26.3		 4fp9F-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 163
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
None
 0.49A 4fp9F-3a4tA:
26.3		 4fp9F-3a4tA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		9 / 12 CYH A  91
PRO A  94
GLY A  95
GLY A  96
LYS A  97
SER A 117
ASP A 142
PRO A 165
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
SFG  A 500 (-3.9A)
None
 0.69A 4fzvA-3a4tA:
26.1		 4fzvA-3a4tA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 5 PRO A  94
GLY A  96
ASP A 142
ASP A 163
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.46A 4n48B-3a4tA:
9.6		 4n48B-3a4tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 7 ARG A 258
ILE A 253
PHE A 267
GLU A 221
 None
 1.40A 4nosC-3a4tA:
undetectable
4nosD-3a4tA:
undetectable		 4nosC-3a4tA:
19.59
4nosD-3a4tA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 139
VAL A 112
ALA A 113
THR A  98
VAL A 133
 None
 1.27A 4oqrA-3a4tA:
undetectable		 4oqrA-3a4tA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 ARG A  14
LEU A 161
PRO A  75
SER A  72
 None
 1.50A 5syjB-3a4tA:
undetectable		 5syjB-3a4tA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  93
PRO A  94
ASP A 142
ASP A  89
LEU A 193
 SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-4.0A)
SFG  A 500 ( 4.4A)
None
 1.08A 5wwsA-3a4tA:
29.5		 5wwsA-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 CYH A  91
ALA A  93
PRO A  94
GLY A  96
ASP A 142
ASP A 163
LEU A 193
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
None
 0.50A 5wwsA-3a4tA:
29.5		 5wwsA-3a4tA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 CYH A  91
ALA A  93
PRO A  94
GLY A  96
LYS A  97
ASP A 142
ASP A 163
 SFG  A 500 (-3.8A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.41A 5wwsB-3a4tA:
29.5		 5wwsB-3a4tA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  96
LYS A  97
SER A 117
ASP A 142
ARG A 144
PRO A 165
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
None
SFG  A 500 (-3.9A)
 0.61A 5zvgA-3a4tA:
31.7		 5zvgA-3a4tA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		7 / 12 PRO A  94
GLY A  96
LYS A  97
SER A 117
ASP A 142
ARG A 144
PRO A 165
 SFG  A 500 (-3.9A)
SFG  A 500 (-3.5A)
SFG  A 500 (-2.8A)
None
SFG  A 500 (-4.0A)
None
SFG  A 500 (-3.9A)
 0.65A 5zvgB-3a4tA:
31.7		 5zvgB-3a4tA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 GLU A 115
ARG A 120
ASP A 142
ASP A 163
 SFG  A 500 (-2.6A)
SFG  A 500 (-4.4A)
SFG  A 500 (-4.0A)
SFG  A 500 (-3.7A)
 0.86A 5zw4A-3a4tA:
15.2		 5zw4A-3a4tA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 208
LEU A  79
ILE A  77
ILE A 268
LEU A 104
 None
 1.15A 6ajiA-3a4tA:
undetectable		 6ajiA-3a4tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 208
LEU A  79
ILE A  77
LEU A 104
LEU A 101
 None
 1.07A 6ajiA-3a4tA:
undetectable		 6ajiA-3a4tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026
(Methanocaldococc
us
jannaschii) 		4 / 6 GLU A  59
LYS A  26
GLU A  30
LYS A  32
 None
 1.09A 6an0A-3a4tA:
3.9		 6an0A-3a4tA:
21.74