SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 5 ASP A 227
HIS A 231
HIS A 270
HIS A 362
 ZN  A1001 ( 2.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 (-4.8A)
ZN  A1001 ( 3.3A)
 0.44A 1ei6A-3a52A:
17.2		 1ei6A-3a52A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 8 ASP A   9
ASP A 227
HIS A 231
HIS A 270
HIS A 362
 SO4  A3004 ( 4.5A)
ZN  A1001 ( 2.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 (-4.8A)
ZN  A1001 ( 3.3A)
 0.46A 1ei6C-3a52A:
17.2		 1ei6C-3a52A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 11 SER A 276
ILE A 191
ALA A 229
LEU A 275
ILE A 226
 None
 1.29A 1uduA-3a52A:
undetectable		 1uduA-3a52A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		3 / 3 ASP A  27
ASN A  25
THR A 287
 None
 0.65A 2pymB-3a52A:
undetectable		 2pymB-3a52A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		3 / 3 ASP A  27
ASN A  25
THR A 287
 None
 0.67A 2q63B-3a52A:
undetectable		 2q63B-3a52A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 8 HIS A 362
HIS A 231
ASP A   9
GLY A  10
 ZN  A1001 ( 3.3A)
ZN  A1001 ( 3.2A)
SO4  A3004 ( 4.5A)
None
 0.91A 3c0zB-3a52A:
2.0		 3c0zB-3a52A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 8 LEU A 209
ALA A 102
LEU A 141
GLN A 204
 None
 0.72A 3cldB-3a52A:
undetectable		 3cldB-3a52A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		3 / 3 TYR A  47
ASP A 366
HIS A 387
 None
 0.95A 3e23A-3a52A:
undetectable		 3e23A-3a52A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 4 GLY A 142
VAL A 107
GLY A 100
THR A  99
 None
 0.90A 3ib2A-3a52A:
1.3		 3ib2A-3a52A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 ASN A 271
GLY A  12
ILE A   5
ASP A   9
PHE A 115
 None
None
None
SO4  A3004 ( 4.5A)
None
 0.96A 3ihtA-3a52A:
2.3		 3ihtA-3a52A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 ASP A 269
SER A  58
SER A  61
THR A 272
VAL A 367
 None
SO4  A3004 (-2.7A)
None
ZN  A1001 ( 4.1A)
None
 1.35A 3mbhB-3a52A:
undetectable		 3mbhB-3a52A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 ASP A 269
SER A  58
SER A  61
THR A 272
VAL A 367
 None
SO4  A3004 (-2.7A)
None
ZN  A1001 ( 4.1A)
None
 1.38A 3mbhE-3a52A:
undetectable		 3mbhE-3a52A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 10 GLY A 223
ASP A   9
GLY A   8
HIS A 231
HIS A 270
 None
SO4  A3004 ( 4.5A)
None
ZN  A1001 ( 3.2A)
ZN  A1001 (-4.8A)
 1.20A 4c5nB-3a52A:
undetectable		 4c5nB-3a52A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 11 ASN A 271
GLY A  12
ASP A 227
ILE A 235
THR A 359
 None
None
ZN  A1001 ( 2.0A)
None
None
 1.16A 4l1aA-3a52A:
undetectable		 4l1aA-3a52A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 GLY A   2
GLY A 216
SER A  98
LEU A 219
HIS A 259
 None
 1.00A 4qdjA-3a52A:
undetectable		 4qdjA-3a52A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 7 THR A 358
GLY A 274
THR A 359
VAL A 365
 None
None
None
MG  A1007 (-3.7A)
 0.99A 4qwpB-3a52A:
undetectable		 4qwpB-3a52A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 10 ASP A 366
HIS A 270
VAL A 367
LEU A  65
ALA A  64
 None
ZN  A1001 (-4.8A)
None
None
None
 1.35A 4yhaB-3a52A:
undetectable		 4yhaB-3a52A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 SER A 360
HIS A 270
HIS A 362
GLY A 361
ASP A   9
 None
ZN  A1001 (-4.8A)
ZN  A1001 ( 3.3A)
None
SO4  A3004 ( 4.5A)
 1.10A 5eeiA-3a52A:
undetectable		 5eeiA-3a52A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 SER A 360
HIS A 270
HIS A 362
GLY A 361
ASP A   9
 None
ZN  A1001 (-4.8A)
ZN  A1001 ( 3.3A)
None
SO4  A3004 ( 4.5A)
 1.10A 5eeiB-3a52A:
undetectable		 5eeiB-3a52A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 ASP A 350
SER A 360
HIS A 270
HIS A 362
ASP A   9
 None
None
ZN  A1001 (-4.8A)
ZN  A1001 ( 3.3A)
SO4  A3004 ( 4.5A)
 1.35A 5ef8A-3a52A:
2.4		 5ef8A-3a52A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 12 ASP A 350
SER A 360
HIS A 270
HIS A 362
ASP A   9
 None
None
ZN  A1001 (-4.8A)
ZN  A1001 ( 3.3A)
SO4  A3004 ( 4.5A)
 1.36A 5ef8B-3a52A:
2.3		 5ef8B-3a52A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 9 ASN A 271
HIS A 362
GLY A 273
GLY A 361
ASP A 227
 None
ZN  A1001 ( 3.3A)
None
None
ZN  A1001 ( 2.0A)
 1.49A 5f8yA-3a52A:
0.0		 5f8yA-3a52A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 9 ASN A 271
HIS A 362
GLY A 273
GLY A 361
ASP A 227
 None
ZN  A1001 ( 3.3A)
None
None
ZN  A1001 ( 2.0A)
 1.48A 5f8yB-3a52A:
0.0		 5f8yB-3a52A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 10 THR A  63
ALA A 113
THR A 111
ALA A  75
GLY A  74
 None
None
MG  A1003 (-4.2A)
None
None
 1.20A 5lf3H-3a52A:
undetectable
5lf3I-3a52A:
undetectable		 5lf3H-3a52A:
21.57
5lf3I-3a52A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		5 / 10 THR A  63
ALA A 113
THR A 111
ALA A  75
GLY A  74
 None
None
MG  A1003 (-4.2A)
None
None
 1.19A 5lf3V-3a52A:
undetectable
5lf3W-3a52A:
undetectable		 5lf3V-3a52A:
21.57
5lf3W-3a52A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 8 THR A 117
LEU A 116
THR A  87
VAL A 218
 None
 1.23A 5ov9B-3a52A:
undetectable		 5ov9B-3a52A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 4 MET A  11
GLY A  10
HIS A 270
GLY A   8
 None
None
ZN  A1001 (-4.8A)
None
 1.42A 6fgdA-3a52A:
2.5		 6fgdA-3a52A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 3a52 COLD-ACTIVE ALKALINE
PHOSPHATASE
(Shewanella
sp.
AP1) 		4 / 4 MET A  11
GLY A  10
HIS A 270
GLY A  12
 None
None
ZN  A1001 (-4.8A)
None
 1.40A 6fgdA-3a52A:
2.5		 6fgdA-3a52A:
22.29