SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		4 / 4 VAL B  84
TRP B  63
ALA B  61
VAL B  14
 None
 1.37A 1gmkA-3a58B:
undetectable
1gmkB-3a58B:
undetectable		 1gmkA-3a58B:
11.88
1gmkB-3a58B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		4 / 8 ASP B  50
SER B   8
ARG B  57
ALA B  61
 None
 1.20A 1rqpC-3a58B:
undetectable		 1rqpC-3a58B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		4 / 8 ARG B 127
GLU B 163
SER B  96
LEU B  93
 None
 0.92A 2bxgA-3a58B:
undetectable		 2bxgA-3a58B:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		5 / 9 THR B 159
ILE B 118
GLY B 160
TYR B 161
GLY B 157
 None
 1.20A 2y7wA-3a58B:
undetectable		 2y7wA-3a58B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3a58 EXOCYST COMPLEX
COMPONENT SEC3
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  96
HIS A  99
SER A  95
 None
 0.90A 4mjwA-3a58A:
undetectable
4mjwB-3a58A:
undetectable		 4mjwA-3a58A:
19.60
4mjwB-3a58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3a58 EXOCYST COMPLEX
COMPONENT SEC3
(Saccharomyces
cerevisiae) 		3 / 3 SER A  95
ARG A  96
HIS A  99
 None
 0.91A 4mjwA-3a58A:
undetectable
4mjwB-3a58A:
undetectable		 4mjwA-3a58A:
19.60
4mjwB-3a58A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		4 / 8 GLU B 163
GLY B 169
THR B  24
PHE B  89
 None
None
MG  B 401 ( 2.8A)
None
 0.91A 5flcB-3a58B:
undetectable		 5flcB-3a58B:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		4 / 8 GLU B 163
GLY B 169
THR B  24
PHE B  89
 None
None
MG  B 401 ( 2.8A)
None
 0.90A 5flcF-3a58B:
undetectable		 5flcF-3a58B:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		5 / 12 ARG B 181
VAL B  58
LEU B  86
SER B 183
LEU B 184
 None
 1.06A 5ikqB-3a58B:
undetectable		 5ikqB-3a58B:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  39
TYR B  71
GLN B  68
 GNP  B 301 (-4.4A)
None
None
 1.08A 5jsdA-3a58B:
undetectable
5jsdB-3a58B:
undetectable		 5jsdA-3a58B:
12.64
5jsdB-3a58B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3a58 GTP-BINDING PROTEIN
RHO1
(Saccharomyces
cerevisiae) 		3 / 3 TYR B  39
TYR B  71
GLN B  68
 GNP  B 301 (-4.4A)
None
None
 1.07A 5jsdB-3a58B:
undetectable
5jsdC-3a58B:
undetectable		 5jsdB-3a58B:
12.64
5jsdC-3a58B:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3a58 EXOCYST COMPLEX
COMPONENT SEC3
(Saccharomyces
cerevisiae) 		3 / 3 THR A 110
THR A 200
LEU A  78
 None
 0.70A 5m66D-3a58A:
undetectable		 5m66D-3a58A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3a58 EXOCYST COMPLEX
COMPONENT SEC3
(Saccharomyces
cerevisiae) 		3 / 3 ILE A 210
VAL A 178
PRO A 226
 None
 0.70A 5uunA-3a58A:
undetectable		 5uunA-3a58A:
23.51