SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 3a5a HEMOGLOBIN V
(Tokunagayusurika
akamusi) 		4 / 4 PHE A 151
ASP A  84
PHE A  87
VAL A 139
 None
 1.00A 1w0fA-3a5aA:
undetectable		 1w0fA-3a5aA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3a5a HEMOGLOBIN V
(Tokunagayusurika
akamusi) 		3 / 3 PHE A 136
ASP A 134
ARG A 112
 None
 0.83A 4eahF-3a5aA:
undetectable		 4eahF-3a5aA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3a5a HEMOGLOBIN V
(Tokunagayusurika
akamusi) 		3 / 3 PHE A 136
ASP A 134
ARG A 112
 None
 0.83A 4eahG-3a5aA:
undetectable		 4eahG-3a5aA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 3a5a HEMOGLOBIN V
(Tokunagayusurika
akamusi) 		4 / 5 PHE A 151
ASP A  84
PHE A  87
VAL A 139
 None
 1.03A 5a1rA-3a5aA:
undetectable		 5a1rA-3a5aA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3a5a HEMOGLOBIN V
(Tokunagayusurika
akamusi) 		4 / 8 PHE A  46
ARG A  69
ILE A  66
GLY A  68
 HEM  A 153 (-3.9A)
HEM  A 153 (-3.6A)
None
None
 0.97A 5nzxA-3a5aA:
undetectable		 5nzxA-3a5aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3a5a HEMOGLOBIN V
(Tokunagayusurika
akamusi) 		3 / 3 CYH A  77
MET A 132
ASN A 135
 None
 1.06A 5qh8A-3a5aA:
undetectable		 5qh8A-3a5aA:
20.29