SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a5f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		5 / 12 ILE A  29
ILE A 132
ILE A  75
VAL A  68
ILE A   3
 None
KPI  A 162 ( 4.8A)
None
None
None
 1.01A 1r5lA-3a5fA:
1.5		 1r5lA-3a5fA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		5 / 12 ILE A  61
GLY A  47
ALA A  10
ILE A  41
GLU A  54
 None
None
KPI  A 162 ( 3.4A)
None
None
 1.47A 1vq1A-3a5fA:
undetectable		 1vq1A-3a5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		5 / 12 ILE A  61
GLY A  47
ALA A  10
ILE A  41
GLU A  59
 None
None
KPI  A 162 ( 3.4A)
None
None
 1.43A 1vq1A-3a5fA:
undetectable		 1vq1A-3a5fA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		5 / 10 LEU A 149
ALA A 160
GLY A 200
ILE A 195
LEU A 182
 None
 1.28A 3ogpB-3a5fA:
undetectable		 3ogpB-3a5fA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		4 / 7 PRO A  73
ILE A  72
GLY A   8
VAL A   9
 None
 1.00A 4a3uB-3a5fA:
8.2		 4a3uB-3a5fA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		4 / 6 ALA A  39
ILE A 192
GLY A 202
ILE A  41
 None
 0.81A 4r21A-3a5fA:
undetectable		 4r21A-3a5fA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		3 / 3 ILE A  40
VAL A   9
PRO A 212
 None
 0.71A 5uunA-3a5fA:
undetectable		 5uunA-3a5fA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		4 / 5 HIS A 119
ALA A  85
SER A  86
GLY A  79
 None
 1.28A 5yodB-3a5fA:
undetectable		 5yodB-3a5fA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3a5f DIHYDRODIPICOLINATE
SYNTHASE
(Clostridium
botulinum) 		4 / 5 HIS A 119
ALA A  85
SER A  86
GLY A  79
 None
 1.23A 5yodD-3a5fA:
undetectable		 5yodD-3a5fA:
24.36