SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 8 ILE A 551
PHE A 504
HIS A 538
LEU A 537
 None
 0.88A 1fslA-3a5iA:
undetectable		 1fslA-3a5iA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 8 VAL A 482
GLU A 483
GLU A 382
ILE A 440
 None
 0.90A 1pk7B-3a5iA:
undetectable		 1pk7B-3a5iA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 LEU A 610
LEU A 654
ILE A 689
THR A 632
LEU A 620
 None
 1.36A 2ft9A-3a5iA:
undetectable		 2ft9A-3a5iA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 LEU A 541
VAL A 540
MET A 554
ILE A 557
ALA A 565
 None
 1.07A 2zbzA-3a5iA:
undetectable		 2zbzA-3a5iA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 6 LYS A 392
GLN A 396
GLY A 399
LEU A 545
 None
 0.90A 3bjwE-3a5iA:
undetectable		 3bjwE-3a5iA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 9 ALA A 644
VAL A 647
ILE A 683
LEU A 677
PHE A 591
 None
 1.41A 3fl9D-3a5iA:
undetectable		 3fl9D-3a5iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 9 ALA A 644
VAL A 647
ILE A 683
LEU A 677
PHE A 591
 None
 1.31A 3fl9H-3a5iA:
undetectable		 3fl9H-3a5iA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		6 / 12 VAL A 671
LEU A 624
LEU A 628
ILE A 689
THR A 632
LEU A 602
 None
 1.20A 3gp0A-3a5iA:
undetectable		 3gp0A-3a5iA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 4 LEU A 413
MET A 374
ILE A 427
ASP A 361
 None
 1.41A 3hecA-3a5iA:
undetectable		 3hecA-3a5iA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 MET A 520
LEU A 523
THR A 524
LEU A 537
LEU A 513
 None
 1.09A 3hm1A-3a5iA:
undetectable		 3hm1A-3a5iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 7 LEU A 544
VAL A 549
VAL A 578
ASP A 553
 None
 0.67A 3rgfA-3a5iA:
undetectable		 3rgfA-3a5iA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 LEU A 657
ALA A 653
LEU A 611
LEU A 610
GLY A 616
 None
 1.25A 3uudA-3a5iA:
undetectable		 3uudA-3a5iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 6 GLY A 460
VAL A 455
PRO A 457
GLY A 430
 None
 0.85A 4dxuA-3a5iA:
undetectable		 4dxuA-3a5iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.27A 4eilA-3a5iA:
undetectable		 4eilA-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 10 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.23A 4eilB-3a5iA:
undetectable		 4eilB-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 7 GLY A 460
VAL A 455
PRO A 457
GLY A 430
 None
 0.87A 4forA-3a5iA:
undetectable		 4forA-3a5iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.27A 4kyaA-3a5iA:
undetectable		 4kyaA-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.28A 4kyaB-3a5iA:
undetectable		 4kyaB-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 10 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.27A 4kyaC-3a5iA:
undetectable		 4kyaC-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.29A 4kyaD-3a5iA:
undetectable		 4kyaD-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.30A 4kyaE-3a5iA:
undetectable		 4kyaE-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.29A 4kyaF-3a5iA:
undetectable		 4kyaF-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 11 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.30A 4kyaG-3a5iA:
undetectable		 4kyaG-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.29A 4kyaH-3a5iA:
undetectable		 4kyaH-3a5iA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		3 / 3 MET A 374
MET A 411
TYR A 418
 None
 1.39A 4p6xI-3a5iA:
undetectable		 4p6xI-3a5iA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 6 ILE A 440
ASP A 456
PRO A 457
ALA A 463
 None
 0.91A 5cu6A-3a5iA:
undetectable		 5cu6A-3a5iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 HIS A 538
LEU A 541
PHE A 400
LEU A 545
PRO A 403
 None
 1.28A 5hnxB-3a5iA:
undetectable		 5hnxB-3a5iA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 LEU A 628
GLN A 631
LEU A 669
VAL A 671
GLY A 601
 None
 1.38A 5i8fA-3a5iA:
undetectable		 5i8fA-3a5iA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 ILE A 420
TYR A 418
HIS A 491
ALA A 432
ILE A 390
 None
 1.22A 5igvA-3a5iA:
undetectable		 5igvA-3a5iA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		4 / 5 ILE A 420
ILE A 407
HIS A 406
VAL A 405
 None
 0.99A 5jmnA-3a5iA:
undetectable		 5jmnA-3a5iA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 12 ALA A 687
GLU A 596
ILE A 683
VAL A 647
PHE A 591
 None
 1.45A 5vlmE-3a5iA:
undetectable		 5vlmE-3a5iA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 10 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.26A 6aogA-3a5iA:
undetectable		 6aogA-3a5iA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA
(Salmonella
enterica) 		5 / 10 VAL A 350
ALA A 352
ASP A 356
VAL A 349
THR A 353
 None
 1.28A 6aogB-3a5iA:
undetectable		 6aogB-3a5iA:
12.80