SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3a5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 7 PRO A 188
ALA A 228
PHE A 269
SER A 270
 None
 1.25A 1lqtA-3a5kA:
undetectable		 1lqtA-3a5kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 7 PRO A 188
ALA A 228
PHE A 269
SER A 270
 None
 1.27A 1lquA-3a5kA:
undetectable		 1lquA-3a5kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		3 / 3 ASN A  44
ASN A  68
ARG A 257
 None
 0.71A 2rlcA-3a5kA:
undetectable		 2rlcA-3a5kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		3 / 3 TRP A 179
VAL A  49
ARG A  47
 None
 0.97A 3b0wA-3a5kA:
undetectable		 3b0wA-3a5kA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		5 / 12 LEU A 251
ILE A 219
GLY A 259
ILE A 261
GLY A 220
 None
 0.99A 3bwcB-3a5kA:
undetectable		 3bwcB-3a5kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		5 / 12 LEU A  83
GLY A 223
SER A 222
LEU A 110
LEU A 260
 None
 1.03A 3e23A-3a5kA:
undetectable		 3e23A-3a5kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		5 / 11 VAL A 108
VAL A 155
TYR A 152
TYR A 176
LEU A 195
 None
 1.37A 3m8pA-3a5kA:
undetectable
3m8pB-3a5kA:
undetectable		 3m8pA-3a5kA:
20.76
3m8pB-3a5kA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		5 / 12 LEU A 227
GLU A 276
ALA A 273
LEU A 232
ALA A 189
 None
 1.30A 3ou6C-3a5kA:
undetectable		 3ou6C-3a5kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 6 TYR A 176
HIS A 175
VAL A 213
PHE A 191
 None
 1.15A 4a97E-3a5kA:
undetectable		 4a97E-3a5kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		5 / 11 VAL A  49
TYR A  66
ALA A  35
SER A  70
PHE A  52
 None
 1.40A 4evrA-3a5kA:
2.8		 4evrA-3a5kA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 8 SER A 201
SER A 203
HIS A 208
ILE A 171
 None
 1.14A 4ms4A-3a5kA:
2.5		 4ms4A-3a5kA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 6 LEU A 110
ASN A 111
LEU A  83
VAL A  49
 None
 1.09A 4okbA-3a5kA:
undetectable		 4okbA-3a5kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 8 GLU A  76
LEU A 234
MET A 235
LEU A 227
 None
 1.09A 5dxeA-3a5kA:
undetectable		 5dxeA-3a5kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens) 		4 / 8 GLU A  76
LEU A 234
MET A 235
LEU A 227
 None
 1.10A 6cbzA-3a5kA:
undetectable		 6cbzA-3a5kA:
13.99